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Hutch News

Stories tagged 'targeted t cell immunotherapy'

Nanoparticles open doors to cancer-fighting CAR T cells

Tiny liposome-based drug carriers make tumors more vulnerable to targeted immunotherapy

July 2, 2018 | By Sabrina Richards / Fred Hutch News Service

Scientists at Fred Hutchinson Cancer Research Center have developed a cheap way to make cancers temporarily vulnerable to immune attack using liposome-based nanoparticles to carry immune-boosting drugs deep into tumors.

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Immunotherapy strategy for ovarian cancer aims to rewire a ‘kill switch’ to ramp-up signal

T cells bearing a new engineered protein boost immunotherapy’s effectiveness in laboratory models of AML, ovarian, pancreatic cancers

April 16, 2018 | By Rachel Tompa / Fred Hutch News Service

In an effort to improve the efficacy of immunotherapy for solid tumors, Fred Hutch researchers have engineered a new type of protein that can rewire a 'kill switch' to stimulate T cells' activity instead.

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New insights into CAR T-cell therapy's potential side effects

Detailed study of cytokine release syndrome and neurologic toxicities could help make emerging cancer immunotherapies safer

Dec. 11, 2017 | By Fred Hutch staff

Detailed studies of two potential side effects of an emerging cancer immunotherapy could eventually help make this strategy, CAR T-cell therapy, safer for patients. The studies examined cytokine release syndrome and neurologic toxicities.

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Dissolving implant could bring immunotherapy to solid tumors

A biopolymer sponge delivers cancer-shrinking T-cell therapy in preclinical study

April 24, 2017 | By Sabrina Richards / Fred Hutch News Service

A dissolving scaffold developed by Dr. Matthias Stephan delivers engineered anti-tumor immune cells to crowded masses of tumor cells and recruits the native immune system to mount a second-wave attack on the cancer.

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Tiny tech reprograms immune cells to fight cancer

Nanoparticles turn immune cells into leukemia-fighting powerhouses while they’re still inside the body

April 17, 2017 | By Sabrina Richards / Fred Hutch News Service

Dr. Matthias Stephan has designed nanoparticles that have the potential to make cellular immunotherapy quicker, cheaper, easier to administer and more widely available, by carrying anti-cancer genes to immune cells still inside the body.

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Immunotherapy for ovarian cancer shows promise in mouse model, but hurdles remain

‘Tumor microenvironment’ poses unique challenges for T-cell therapy in solid tumors

April 4, 2017 | By Rachel Tompa / Fred Hutch News Service

A major roadblock to adopting T-cell therapy to solid tumors is what’s known as the tumor microenvironment, the local milieu of non-cancerous cells and molecules in and around the tumor. Fred Hutch researcher Dr. Kristin Anderson and her colleagues in Dr. Phil Greenberg's lab are working to overcome those barriers.

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