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Stories tagged 'gene mutation'

Good News at Fred Hutch

Celebrating faculty and staff achievements

Sept. 30, 2016

Good News: Dr. Jeff Whiteaker wins NCI Research Specialist Award; Human Biology gains four new faculty members

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Inherited mutations tied to advanced prostate cancer

Genetic screening could help men with prostate cancer find better treatments — and alert family members to their own cancer risk

July 6, 2016 | By Sabrina Richards / Fred Hutch News Service

A new study shows men with metastatic prostate cancer are five times likelier to harbor inherited mutations in BRCA1/2 and other DNA-repair genes than the general population, irrespective of age or family history of prostate cancer.

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Study sheds new light on molecular pathways behind marrow disorders

How a single alteration in fundamental cellular machinery drives blood diseases and cancers

May 11, 2015 | By Rachel Tompa / Fred Hutch News Service

Researchers have now uncovered how a single mutation can trigger myelodysplastic syndrome, or MDS, a disorder akin to leukemia in which the bone marrow overproduces some blood cell precursors but can’t convert them to healthy blood cells.

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Muscular dystrophy: zeroing in on a cause

Tapscott, Snider and global research team further understanding of key genetic mutation, reveal possible drug targets

Aug. 23, 2010 | By Kristen Woodward

An international team of researchers that includes investigators from the Fred Hutchinson Cancer Research Center made a critical advance in determining the cause of a common form of muscular dystrophy known as facioscapulohumeral dystrophy.

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Gene mutation boosts breast cancer risk contralaterally

PHS findings on BRCA mutations underscore importance of genetic testing in younger patients

April 12, 2010 | By Kristen Woodward

Fred Hutchinson Cancer Research Center Public Health Sciences Division’s Dr. Kathi Malone and colleagues found that women with breast cancer before age 55 who carry an inherited mutation in the breast cancer susceptibility genes BRCA1 or BRCA2 are four times more likely to develop cancer in the breast opposite, or contralateral, to their initial tumor as compared to breast cancer patients without these genetic defects.

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Funds for lung cancer biomarker research

Mouth-cell test holds promise for weighing lung cancer risk

Feb. 1, 2010

Dr. Jason Chien of the Fred Hutchinson Cancer Research Center's Clinical Research Division recently received a one-year, $75,000 grant from the Department of Defense Lung Cancer Research Program to study mouth cells as a possible biomarker for lung cancer.

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