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Hutch News

Stories tagged 'broadly neutralizing antibodies'

Engineering vaccine-like protection without a vaccine

CRISPR gene-editing used on antibody-making B cells

May 17, 2019 | By Sabin Russell / Fred Hutch News Service

A Hutch team led by Dr. Justin Taylor shows that B cells, which are crucial components of the immune system, can be genetically engineered to make exactly the antibodies we want. It could lead to a potentially more precise and dependable way to generate protection without vaccines.

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Could an infant’s blood sample help model a better HIV vaccine?

Tracing the evolution of a baby’s special HIV-blocking protein

May 16, 2019 | By Sabrina Richards / Fred Hutch News Service

A 25-year-old blood sample from an infant infected with HIV could hold clues to modeling a better HIV vaccine.

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Cutting-edge approach maps HIV's escape routes

Atlas of immune-evading HIV mutations could inform design of new treatments, vaccines

Jan. 29, 2019 | By Sabrina Richards / Fred Hutch News Service

Fred Hutch scientists have constructed an atlas of mutations that HIV uses to escape broadly neutralizing antibodies, potent immune molecules that form our body’s first line of defense against the virus. The information could help guide researchers who are testing these antibodies’ potential to prevent or treat HIV infection, as well as those working to develop more effective preventive vaccines.

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