Computational Biology

Vaccine and Infectious Disease Division

Computational Biology

VIDD computational biology scientists develop novel computational methods and tools that are applied to genomic statistics and high throughput biological assays for a better understanding of infectious disease processes and host immune responses. These researchers combine empirical data with mathematical computational methodologies for deciphering the complexities of human disease.


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Senior Staff Scientist, McElrath Lab, Vaccine and Infectious Disease Division
Research interests include early innate immune responses to HIV vaccines on subsequent adaptive immune responses and systems biology analyses of how immune responses are shaped
Characterizes virus diversity, evolution, circulation patterns. Identifies epidemiological patterns from sequence data and develops methods to predict evolutionary growth or decay across strains.
Phone: (206) 667-6372
Correlates analysis, sieve analysis and antigenic mapping focusing on HIV-1 vaccines and immunology
Phone: (206) 667-2569
Fax: (206) 667-4378
Research Associate Professor, Laboratory Medicine, University of Washington
Graduate Faculty, Laboratory Medicine, University of Washington
Director, Center for AIDS Research Immunology Core, University of Washington
Characterizing T cells induced by candidate vaccines using flow cytometry. Developing new assays to evaluate vaccine efficacy with HIV Vaccine Trials Network. Studies include examining T cell function at the single-cell level using advanced flow cytometric techniques; examples include T cell responses to vaccination and to viral infections such as CMV, EBV, HIV, and hepatitis B.
Affiliate Assistant Professor, Biostatistics, University of Washington
Statistical and computational methods for bioinformatics applications, statistical modeling for genome sequence analysis and statistical modeling frameworks. The interface between computer science, statistics, and molecular biologyand such as development of new informatics methods in genomics and post-genomics
Phone: (206) 667-4086
Fax: (206) 667-4378
Computational and statistical methods development for high-throughput, high-content biological data. Modeling and integration of data from high throughput assays for biomarker discovery, clinical outcome prediction and disease classification.
Phone: (206) 667-3116
Fax: (206) 667-4378
Current studies include development of methods for T-cell based sieve analysis, quantification of vaccine induced T cell responses, systems biology of influenza and time-dependent correlates analysis of HIV efficacy trial.
Principal Investigator, Statistical Data Management Center, HIV Vaccine Trials Network
Research Professor, Biostatistics, University of Washington
Graduate Faculty, Biostatistics, University of Washington
Research focus includes vaccine clinical trials, the design and analysis of Phase I/II trials, for evaluating vaccine effects on immune responses; the design and analysis of Phase 2b/III trials, for evaluating vaccine efficacy, immune correlates, sieve analysis, and post-infection vaccine effects; general biostatistical methods research, such as survival analysis, causal inference, and evaluation of surrogate endpoints
Phone: (206) 667-7299
Fax: (206) 667-4812
Scientific Director, Translational Data Science Integrated Research Center, Fred Hutchinson Cancer Research Center
J. Orin Edson Foundation Endowed Chair, Fred Hutchinson Cancer Research Center
Affiliate Professor, Statistics, University of Washington
Developing methods and tools for high-throughput, high-dimensional experiments with applications in vaccine research, immunology and immunotherapy; flow cytometry, peptide microarrays, next generation sequencing; Bayesian inference and computation and statistical computing
Phone: (206) 667-4076
Fax: (206) 667-4378
Professor, Biostatistics, University of Washington
Adjunct Professor, Applied Mathematics and Epidemiology, University of Washington
Director and Founder, Summer Institute in Statistics and Modeling in Infectious Diseases, University of Washington
Research focus included the design and evaluation of vaccine field trials; modeling infectious disease dynamics and strategies for mitigation and control; causal inference in infectious diseases; and evaluating surrogates of protection.
Phone: (206) 667-2722
Fax: (206) 667-4378
Associate Director for Laboratory Operations, HIV Vaccine Trials Network (HVTN)
Immunologic endpoint determination for experimental vaccines (HIV, pneumococcus, malaria, TB, flu) and Logistics, operations, quality assurance, and assay validation for immunologic evaluation of vaccines in the clinical trial setting
Research focus includes statistical methods for bioassays (e.g., flow cytometry, sequencing); dynamic modeling of biological systems (e.g., multi-type cell populations, B-cell repertoire); nonparametric methods for supervised and unsupervised learning; stochastic processes (e.g., branching processes); algorithms for scalable data analysis.
Phone: (206) 667-2809
Fax: (206) 667-4378
Design and analysis of vaccine efficacy trials, genotype-specific vaccine efficacy-based sieve analysis,immune correlates of vaccine protection, analysis of vaccine-induced immune response durability and survival analysis
Phone: (206) 667-5568
Staff Scientist, Fredricks Lab, Vaccine and Infectious Disease Division
Research focus includes the role of the microbiome in human health and disease.
Phone: (206) 667-2884
Structure-based vaccine design has proven possible for certain pathogens and my research aims at applying this paradigm to HIV-1 vaccines
Phone: (206) 667-6585
Senior Staff Scientist, Fredricks Lab, Vaccine and Infectious Disease Division
Research focus includes ecology of human microbial communities, impact of bacterial interactions on health and disease, molecular diagnosis of bacterial pathogens and bacterial adaptive responses