Labs & Groups

Scientific Labs / Programs

Labs & Groups

View our alphabetical list or search for a specific lab or group.

  • Adair Lab
    Clinical Research
    Develops new gene therapy treatments and protocols for the treatment of many different genetic and infectious diseases
  • Ahmad Lab
    Basic Sciences
    Focused on how chromatin structure and dynamics affect gene regulation and transcription.
  • Bai Lab
    Basic Sciences
    The Bai Lab research goal is to understand how synapses develop into functional circuits. Synaptic connections undergo constant fine-tuning to support information delivery and storage in the brain.
  • Bedalov Lab
    Clinical Research
    The Bedalov Lab conducts research to identify drugs that disrupt gene silencing, a process that has been implicated in cancer and other diseases in which genes are inappropriately shut off.
  • Bedford Lab
    Vaccine and Infectious Disease
    The Bedford Lab works at the interface of evolution, epidemiology and immunology. We apply computational and statistical methods to sequence data to understand viral dynamics, looking at the geographic circulation of viral strains and their evolution.
  • Berger Lab
    Human Biology
    The goal of the Berger laboratory is to enable precision medicine by systematically uncovering the molecular alterations in cancer, determining the function of these variant alleles, and understanding how these alleles modulate response to targeted or immune-based therapies.
  • Bernstein Lab
    Clinical Research
    Dr. Irwin D. Bernstein's research interests include normal and leukemic hematopoietic stem cells, antibody targeted therapies for lymphoma and leukemia, and the biology of acute myeloid leukemia.
  • Beronja Lab
    Human Biology
    Regulation of epithelial growth in development and cancer. Tissue growth is a fundamental biological process that generates functional organs in development, and maintains them in the adulthood through continuous cycles of renewal and repair.
  • Bielas Lab
    Public Health Sciences, Human Biology
    The Bielas Lab studies the fundamental and clinical implications of nuclear and mitochondrial DNA mutations in the development of cancer and age-related disease. Translational research projects explore the potential utility of these mutations as novel DNA biomarkers for improved disease detection, treatment outcome, survival and quality of life.
  • Biggins Lab
    Basic Sciences
    The Biggins Lab uses budding yeast to study chromosome segregation, the process by which chromosomes are distributed to new cells during cell division. Cells with an abnormal number of chromosomes are a hallmark of cancer and many birth defects.
  • Biomarkers Lab
    Public Health Sciences
    The Biomarker Lab, within the Cancer Prevention Program in the Public Health Sciences Division, supports epidemiological & clinical studies. We collaborate with researchers both internally at the Fred Hutchinson Cancer Research Center and at other institutions such as Harvard, Tufts, University of Washington, and the National Institute on Aging.
  • Bleakley Lab
    Clinical Research
    Strategies to engineer hematopoietic stem cell grafts to prevent GVHD and augment graft-versus-leukemia in order to prevent relapse, adoptive T cell immunotherapy to augment graft-versus-leukemia and histocompatibility antigens as targets for future immunotherapy, graft engineering to manage relapse after transplant.
  • Bloom Lab
    Basic Sciences
    The Bloom lab uses a combination of experimental and computational approaches to study the molecular evolution of proteins and viruses. A major goal is to understand the underlying biophysical and immunological constraints that shape influenza evolution.
  • Boeckh Lab
    Vaccine and Infectious Disease
    The long-term goal of the Boeckh Research Program is to prevent infectious disease in immunocompromised hosts and reduce the severity of infections that do occur. We focus on herpes viruses (primarily cytomegalovirus), respiratory viruses, and the genetics of susceptibility to infection.
  • Bolouri Lab
    Human Biology
    The Bolouri Lab is interested in understanding how gene regulatory interactions control cellular state and identity, particularly during development (e.g. in stem cells). The lab specializes in the development and use of computational systems biology methods to map gene regulatory networks.
  • Bradley Lab
    Basic Sciences
    The Bradley Lab uses genomics and molecular genetics to study alternative splicing, the process by which a single gene can give rise to multiple, distinct protein isoforms. Alternative splicing enormously increases the complexity of eukaryotic genomes, and plays important roles in many human diseases.
  • Breeden Lab
    Basic Sciences
    The Breeden Lab investigates control of cell division in budding yeast, with a long-term goal of understanding how the commitment to the mitotic cell cycle is regulated in response to environmental and internal cues.
  • Brent Lab
    Basic Sciences
    The Brent Lab studies how living cells sense, represent, transmit and act upon information to make decisions about their future states. The lab includes, experimentally, a social science component, in which lab members are encouraged to identify and analyze how their research outcomes and ongoing increases in biological knowledge might impact human affairs.
  • Buck Lab
    Basic Sciences
    The Buck lab studies the mechanisms and neural circuits that underlie the sense of smell and pheromone sensing in mammals. They are also interested in aging.
  • Carlson Group
    Public Health Sciences
    The Carlson Group uses genetic epidemiology to investigate the genetic risk factors of diseases such as cancer, cardiovascular and neurological disease. The group identifies statistical correlations between variations and disease. The group's molecular biology laboratory is then equipped to assess the molecular mechanisms behind these correlations. Recently, the lab has played a significant role in development of technologies for adaptive immune system profiling, in collaboration with Harlan Robins and Hootie Warren. These tools are being applied to a variety of arenas.
  • Ceballos Studies
    Public Health Sciences
    The group's research emphasizes the development of culturally-appropriate interventions, the inclusion of community collaboration in research, and use of biobehavioral methods to assess program effectiveness.
  • Chapuis Lab
    Clinical Research
    Focused on understanding the factors associated with successful therapies so that adoptive T cell therapies can be further optimized to better eliminate tumors.
  • Chen Group
    Vaccine and Infectious Disease
    Statistical methods for time-varying disease, combination HIV prevention approaches and adherence to HIV prevention. Analysis of pediatric clinical trials.
  • Chen Lab
    Public Health Sciences
    The Chen Lab's goal is to understand the molecular epidemiology and etiology of oral, lung and endometrial cancers.
  • Cheung Lab
    Public Health Sciences
    The major focus of the Cheung laboratory is to understand the cellular and molecular mechanisms by which tumor cell clusters invade and metastasize to distant sites.
  • Ching-Yun Wang Group
    Public Health Sciences
    Research is centered on measurement error, missing data, physical activity and dietary intake data, joint modeling of survival and longitudinal data, and analysis of clinical trials.
  • Clurman Lab
    Clinical Research
    The Clurman Lab studies how cell division is regulated in normal cells, and how abnormal control of cell division leads to cancer. They hope to use these mechanistic insights into tumor formation to develop new cancer treatment strategies.
  • Computational Biology
    Public Health Sciences
    Members of the Computational Biology Program use and develop novel computational methods, often in combination with wet-laboratory experiments, to investigate biological mechanisms across a broad range of topics.
  • Cooper Lab
    Basic Sciences
    The Cooper Lab investigates proteins involved in the signaling pathways that allow cells to communicate with each other. In particular, they study a protein called Disabled and the Src protein family to better understand how they regulate normal cell behavior and the transformation of normal cells to cancer cells.
  • Corey Lab
    Vaccine and Infectious Disease
    The Corey Lab investigates the underlying mechanisms between herpes simplex virus pathogenesis and the host immune response.
  • Dai Lab
    Public Health Sciences
    Statistical genetics and genomics, design and analysis of randomized clinical trials, statistical methods for high-dimensional feature selection and prediction, gene-treatment interaction, mediation and instrumental variables regression.
  • Delaney Lab
    Clinical Research
    The focus of the Delaney Lab is the development and clinical translation of methodologies for the ex vivo expansion of hematopoietic stem and progenitor cells. In particular, cord blood stem and progenitor cells with the goal of improving outcomes for patients undergoing cord blood transplantation.
  • Dey Lab
    Clinical Research
    The Dey lab studies how the gut microbiome influences physiology and pathophysiology in health and disease.
  • Dudakov Lab
    Clinical Research
    The focus of the Dudakov lab is to elucidate the mechanisms underlying endogenous thymic regeneration so that they may be exploited into therapeutic strategies to boost immune function.
  • Duerr Lab
    Vaccine and Infectious Disease
    Research is focused on intervention among African women to prevent mother-to-child HIV transmission via breastfeeding and on trials of prophylactic HIV vaccines for the HIV Vaccine Trials Network (HVTN).
  • Edlefsen Group
    Vaccine and Infectious Disease
    Conducts a wide range of research involving statistical and computational methods for comparing and contrasting DNA and RNA genomic sequences and understanding why HIV vaccines succeed or fail.
  • Eisenman Lab
    Basic Sciences
    The Eisenman Lab studies how cell proliferation, growth, and differentiation are regulated through the actions of transcriptional networks, and how this regulation is undermined during tumor progression. The lab employs the tools of molecular biology as well as mammalian and Drosophila genetics to study basic mechanisms underlying normal and abnormal cellular functions.
  • Emerman Lab
    Basic Sciences, Human Biology
    The Emerman Lab studies the molecular and evolutionary basis for the replication of HIV and related viruses, with an emphasis on the interaction of these viruses with their host cells. Their goal is to understand what determines resistance or vulnerability to current, past and potential viral diseases.
  • Etzioni Lab
    Public Health Sciences
    The Etzioni Lab focuses on statistical methods for prostate-cancer studies, with the goal of improving guidelines for screening and treatment. Etzioni has assessed the likely impact of prostate-specific antigen testing on prostate-cancer incidence and mortality, and developed approaches for evaluating new cancer-screening biomarkers.
  • Fong Group
    Vaccine and Infectious Disease
    The Fong Group specializes in using biostatics and computer modeling to investigate complex biological problems, with an emphasis on vaccine development. The group is working together with other Fred Hutch researchers to evaluate immune responses to HIV vaccines, and to design and analyze HIV vaccine trials.
  • Fredricks Lab
    Vaccine and Infectious Disease
    The Fredricks Laboratory studies the human indigenous microbiota to determine how changes in microbial communities impact human health.
  • Galloway Lab
    Public Health Sciences, Human Biology
    The Galloway Lab studies the mechanisms by which human papillomaviruses contribute to cancer, with an emphasis on types most likely to progress to cervical cancer. They work to understand the natural history of genital HPV infections and why only a small subset of women infected with high-risk HPVs develop cancer.
  • Geballe Lab
    Clinical Research, Human Biology
    The Geballe Lab studies the functions and mechanisms of genes encoded by large DNA viruses, such as cytomegalovirus and vaccinia virus, that act to promote viral growth by blocking host cell defenses.
  • Gottardo Lab
    Vaccine and Infectious Disease
    The Gottardo Lab conducts research in computational biology and statistical genomics with applications to high throughput biological assays and immunology.
  • Gottschling Lab
    Basic Sciences
    The Gottschling Lab uses budding yeast as a model system to investigate fundamental questions in biology. One of their current areas of research interest is the striking link between increasing age and cancer incidence in humans.
  • Green Lab
    Clinical Research
    The Green lab is investigating new immunotherapy based approaches to treat multiple myeloma (MM) and lymphoma. Ideally, a tumor target (antigen) should be expressed homogeneously on the cancer cell’s surface and not be found on normal tissue.
  • Greenberg Lab
    Clinical Research
    Research is focused on the immunobiology of viral and malignant diseases, and developing cellular and molecular strategies to manipulate T cell immunity for the treatment of human diseases.
  • Gujral Lab
    Human Biology
    Research is focused on the fundamental properties of cell regulation and signal pathways that drive cancer metastasis
  • Hahn Lab
    Basic Sciences
    The Hahn Lab studies the mechanism and regulation of transcription, the process of mRNA synthesis. Transcriptional regulation is one of the key steps controlling cell growth, differentiation and development, and defects cause many human illnesses. Using biochemistry, structural biology and molecular genetics, the lab focuses on the mechanism of the large conserved protein complexes that regulate and promote transcription.
  • Hatch Lab
    Basic Sciences
    Understanding molecular mechanisms that initiate NE disruption in interphase and how defects in NE stability impact cancer development and disease pathogenesis
  • Health Communication Research Center
    Public Health Sciences
    The goal of HCRC is to develop, test, evaluate, and disseminate theory-based health communication interventions using various media including prints, podcasts, internet websites, and social media.
  • Heimfeld Lab
    Clinical Research
    The Heimfeld Lab focuses on the translation of new cell-based therapies from the scientist's bench to the patient's bedside. Areas of research include improvements in specific cell-subset selection, large-scale therapeutic-cell culturing in closed systems, optimized cryopreservation and cell storage.
  • Henikoff Lab
    Basic Sciences
    The Henikoff Lab studies the structure, function and evolution of chromosomes. They also develop tools for epigenomics and functional genomics.
  • Hingorani Lab
    Clinical Research
    Investigates the molecular and cellular mechanisms that drive the pathogenesis of pancreatic ductal adenocarcinoma (PDA) or, more commonly, pancreas cancer.
  • Hladik Lab
    The Hladik Lab conducts studies and uses systems biology tools to understand the interplay between pathogens, the mucosa, and medical interventions to improve the prevention and treatment of sexually transmitted diseases, especially HIV.
  • Hockenbery Lab
    Clinical Research, Human Biology
    The Hockenbery lab studies programmed cell death (apoptosis) pathways that are defective in many cancer cells; and the role of cancer-cell metabolism in apoptosis, oncogene functions, and environmental/dietary risk factors, including excess supply of nutrients. After identifying cancer-selective targets, they carry out small-molecule screens for inhibitors to identify lead compounds as anticancer agents.
  • Holland Lab
    Human Biology
    The Holland lab works at the intersection of multiple disciplines to address the molecular basis of brain tumors and develop new approaches to their treatment. Our research focuses on developing mouse models of brain cancer that mimic the behavior of the disease in patients. Our work with mouse models has led to clinical trials in glioma patients. We also have developed imaging strategies to follow mouse brain tumors as they develop—a powerful system that is used to test promising new drugs with potential benefit for patients.
  • Hsieh Lab
    Human Biology
    The primary focus of the Hsieh lab is to unravel the post-transcriptional mechanisms that govern the genesis and progression of epithelial malignancies. Our research seeks to understand how rogue cells co-opt the critical interface between RNA and the protein synthesis machinery to drive specific cancer behavior at a molecular, cellular, and organismal level.
  • Hsu Lab
    Public Health Sciences
    Research area is statistical genomics, including assessing familial aggregation using variable age at onset as disease outcomes, discovering latent genes via linkage and association techniques, and characterizing the effect of the genes and their interaction with environmental risk factors on the time course of the disease.
  • Huang Group
    Vaccine and Infectious Disease
    The Huang Lab focuses on the evaluation of biomarkers for disease prevention and control. The lab also studies genetic epidemiology, particularly the detection of gene-environment interactions based on genome-wide association studies and the construction of risk prediction models using the genetic regulatory network.
  • Hutch Data Commonwealth
    The Hutch Data Commonwealth (HDC) team website provides detailed insight on how the HDC is bringing big data and analytics capabilities and accessibility to all Hutch Investigators. You will find information such as: our current projects, emerging products, our people and teams, as well as a list of tools that you can use today.
  • J. Lee Nelson Lab
    Clinical Research
    The J. Lee Nelson Lab studies microchimerism, a natural state in which cells are exchanged between mother and fetus during pregnancy and can remain in the other individual decades later. They study the role of this phenomenon in autoimmune diseases, pregnancy complications and cancer, as well as its impact on the success of blood stem-cell and organ transplants.
  • Janes Lab
    Vaccine and Infectious Disease
    The Janes Lab applies statistical methods for evaluating biomarkers for disease diagnosis/screening, risk prediction and treatment selection.
  • Jerome Lab
    Vaccine and Infectious Disease
    Research focuses on the chronic and latent phases of virus infections, virus immune evasion mechanisms, and potential curative therapeutic approaches to these infections.
  • Kemp Lab
    Public Health Sciences, Human Biology
    The Kemp Lab studies tumor formation in mice to better understand how environmental and genetic factors interact to cause cancer. They also work to develop simple blood tests for early cancer detection by discovering biomarkers, the proteins that signal the earliest traces of disease.
  • Kiem Lab
    Clinical Research
    The Kiem Lab studies stem cell biology and stem cell gene transfer with the goal of developing new treatment strategies for patients with genetic and infectious diseases and cancers.
  • Kooperberg Website
    Public Health Sciences
    Research is focused on the development of statistical methodologies and software for large public health studies.
  • Kratz Lab
    Public Health Sciences
    The Kratz lab studies the relationship between diet, obesity, and chronic diseases such as type 2 diabetes, cardiovascular disease, and obesity-associated types of cancer. To improve our understanding of these relationships, we conduct translational and clinical studies in healthy men and women, or individuals suffering from specific conditions.
  • Kugel Lab
    Human Biology
    The Kugel Lab primary research theme is to study how the dysregulation of chromatin modifying enzymes contributes to pancreatic cancer pathogenesis and, further, whether these pathways present liabilities that could be exploited for cancer therapy.
  • Laboratory for the Study of Metastatic Microenvironments
    Human Biology
    Dr. Ghajar directs the Laboratory for the Study of Metastatic Microenvironments (LSM2). The goal of his research program is to understand how microenvironments within distant tissues regulate dormancy and growth of disseminated tumor cells (DTCs), and whether these niches convey chemoresistance to dormant DTCs. His belief is that solving these puzzles will allow the development of therapeutic regimens that eradicate dormant DTCs before they can develop into full-blown metastases.
  • Lampe Lab
    Public Health Sciences, Human Biology
    The Paul Lampe Lab attempts to discover early detection cancer biomarkers and investigates the control of cell growth at the cell biology level. Of particular interest is the role that gap junctions play in the regulation of cell growth and the cell cycle, and the disruption of this relationship during cancer development.
  • Lee Lab
    Clinical Research
    Our work focuses on hematopoietic stem cell transplant patients and chronic graft-versus-host disease (cGHVD). Dr. Lee is the lead investigator and Fred Hutchinson Cancer Research Center is the coordinating center for the Chronic Graft-versus-Host Disease Consortium within the Rare Diseases Clinical Research Network.
  • Li Lab
    Public Health Sciences
    Dr. Li uses a multidisciplinary approach to understand factors related to the causes and patient outcomes of breast cancer. Current projects include identifying new biomarkers that could be used for early detection, evaluating risk factors for different types of breast cancer, determining predictors of poor outcomes among breast cancer survivors, and assessing disparities in cancer stage, treatment and survival by race/ethnicity.
  • Lund Lab
    Vaccine and Infectious Disease
    The Lund lab research is focused on elucidating the basic mechanisms of immunity in the context of virus infection. Specifically, we use a mouse model to study how regulatory T-cells affect the anti-viral immune responses to genital HSV-2, influenza, and West Nile virus.
  • MacPherson Lab
    Public Health Sciences, Human Biology
    The MacPherson Lab is focused on understanding the mechanisms through which cancer-mutated genes drive tumorigenesis. The lab studies small cell lung cancer and other solid tumors. We generate novel genetically engineered mouse models that we use to interrogate the biology underlying major cancer driver genes. We are particularly interested in understanding epigenetic regulators that are genetically mutated in human tumors.
  • Madeleine Lab
    Public Health Sciences
    Dr. Madeleine's research focuses primarily on the molecular epidemiology of disease-causing agents, or pathogens, and the immune response to them that may be associated with cancer development and prognosis. Another interest is the role of chronic, undiagnosed immune system dysfunctions (such as those occurring with age, obesity, physical inactivity, hormone use, and UV exposure) in cancer development.
  • Malik Lab
    Basic Sciences
    The Malik Lab hunts for rapidly evolving proteins in order to understand how conflicts between genes affect human evolution. Such genetic conflicts can arise between virus and host genes as each fights for survival, but they can affect the function of essential genes, including those implicated in cancer.
  • Matsen Group
    Public Health Sciences
    Research is focused on the development and application of evolutionary methods for molecular sequence data (i.e. DNA and RNA).
  • McElrath Lab
    Vaccine and Infectious Disease
    The McElrath Lab is dedicated to understanding the human immune response mechanisms in HIV infection and resistance in a way that can be translated into the development of an effective HIV vaccine.
  • Mendez Lab
    Clinical Research
    Our research is looking to discover which genes are related specifically to the spread of head and neck cancers to other parts of the body by comparing the genetics of tumors that have not spread with those that have. We hope to one day allow physicians to predict which tumors are more likely to spread, information that will, in turn, affect treatment decisions.
  • Moens Lab
    Basic Sciences
    The Moens Lab uses zebrafish as a model system to study how genes control the early development of the brain in vertebrates. Their work adds to our understanding of the causes of cancer because many of the genes that control embryonic development are the same ones that are wrongly regulated in cancer cells.
  • Molecular Epidemiology Lab
    Public Health Sciences
    The Molecular Epidemiology Lab provides investigators working on population-based studies with laboratory-based research expertise through a collaborative scientific relationship and supports epidemiological and clinical investigators at Fred Hutch and their collaborators at other institutions.
  • Mueller Lab
    Public Health Sciences
    Dr. Mueller's research focuses on the roles of maternal, gestational, early life factors, and early environmental exposures in the occurrence of childhood cancer and autoimmune diseases. She also studies reproductive history in relation to cancer and cancer survival in women, and reproductive outcomes among male and female childhood cancer survivors.
  • Oehler Lab
    Clinical Research
    Research and clinical focuses on the mechanisms of leukemia disease initiation/progression and therapy resistance, new agents in the treatment of chronic myeloid leukemia (CML) and acute myeloid leukemia (AML), including myeloproliferative and myelodysplastic disorders.
  • Olson Lab
    Clinical Research
    The Olson Lab studies pediatric brain tumors, brain development and neurodegenerative disorders. The lab has a strong focus on emergent technologies such as "tumor paint," which causes cancer cells to glow with light so that surgeons can see them during an operation.
  • Orozco Lab
    Clinical Research
    Focus on developing and improving antibody therapies for leukemia and lymphoma patients, with the goal of translating laboratory findings into the clinic and increasing the effectiveness of radioimmunotherapy by developing “pre-targeted” methods for more selectively delivering radiation to tumor sites.
  • Overbaugh Lab
    Public Health Sciences, Human Biology
    The Overbaugh lab has a long-standing interest in understanding the mechanisms of HIV-1 transmission and pathogenesis. The lab is part of a larger team, comprising researchers in both Seattle and Kenya (The Nairobi HIV/STD Project). Trainees in the lab have opportunities to engage in studies of viral evolution, virus-host cell interactions, and viral immunology all within the context of international collaboration.
  • Paddison Lab
    Public Health Sciences, Human Biology
    The Paddison Lab uses functional genetics to probe the underlying biology of mammalian stem/progenitor cells. We identify and characterize gene products affecting stem cell self-renewal, differentiation, proliferation, or survival through the use of RNAi knockdown technologies.
  • Parkhurst Lab
    Basic Sciences
    The Parkhurst Lab studies how genes get turned on and off as fruit-fly embryos develop and how errors in this process can lead to cancer and other diseases. They also investigate wound healing and complex signals involving proteins that can affect a cell's "skeletal" structure.
  • Paulovich Lab
    Clinical Research
    The Paulovich Lab works to characterize human variation and to relate this variation to clinically relevant endpoints, such as predicting a patient's risk of cancer and tolerance for treatments. Projects range from studying cellular DNA damage response in yeast and mammalian cells, to developing novel mass spectrometry-based technologies for finding and validating new protein biomarkers to serve as diagnostic tests.
  • Pepe Lab
    Public Health Sciences
    The Pepe Lab develops guidelines and software to promote the use of sound statistical methods by scientists who are working to evaluate diagnostic or prognostic medical devices and biomarkers.
  • Pergam Group
    Vaccine and Infectious Disease
    The Pergam Group collaborates on research which studies the prevention of infections in patients with cancer, transplant recipients and other immunocompromised populations
  • Peter Gilbert Group
    Vaccine and Infectious Disease
    The Gilbert Group is currently interested in research centered on the statistical design and analysis of HIV vaccine efficacy trials, with emphasis on assessing immune correlates of vaccine-induced protection including the “sieve analysis” of the HIV sequences infecting trial volunteers.
  • Peter Nelson Lab
    Public Health Sciences, Human Biology
    Dr. Peter Nelson's lab focuses on understanding the molecular, cellular and physiological events that lead to cancer initiation and progression. A particular emphasis involves hormonal carcinogenesis and prostate cancer with the goal of developing new strategies for diagnosis, prognosis and therapy.
  • Peters Studies
    Public Health Sciences
    Peter's Lab research is focused on the genetic and molecular epidemiology of common complex diseases, including cancer, obesity, type 2 diabetes, and cardiovascular diseases, as well as intermediate traits, including inflammation and metabolic measurements. Within well characterized and diverse study populations, we are studying the impact of common and rare genetic variants across the entire genome, as well as interactions between genetic variants and environmental factors (such as diet, exercise, smoking and aspirin use).
  • Pollack Lab
    Clinical Research
    The Pollack Lab is developing new ways to culture and engineer T cells with sarcoma specificity and learning how to overcome the inhibitory effects of the sarcoma tumor microenvironments on what might otherwise be effective immunotherapies
  • Porter Lab
    Public Health Sciences, Human Biology
    The Porter Lab focuses on identifying and understanding the molecular events in normal and cancer cells that are associated with the initiation and progression of human cancer, with a focus on breast and ano-genital cancers. They also investigate the molecular profiles that distinguish different types of cancer or determine an individual's cancer risk.
  • Press Lab
    Clinical Research
    Dr. Press is a pioneer in immunotherapy, a treatment strategy that harnesses the power of the immune system. His lab engineers antibodies that help to destroy cells involved in blood cancers and carry radiation directly to cancer cells. They also genetically modify disease-fighting T-cells to boost their ability to recognize and kill lymphoma cells.
  • Priess Lab
    Basic Sciences
    The Priess lab studies how cells coordinate their shape and fate during the development of complex tissues and organs. Most of these studies use the nematode C. elegans as a model organism.
  • Prlic Lab
    Vaccine and Infectious Disease
    The Prlic Lab primarily focuses on two populations of the adaptive immune system: CD8 T cells and NK cells. The lab studies these cells in a variety of different in vivo (mouse) and in vitro model systems to gain mechanistic insight and learn how to manipulate these cells for therapeutic purposes.
  • Radich Lab
    Clinical Research
    The Radich Lab studies the molecular genetics of response, progression and relapse in human leukemia. Research topics include the detection of minimal residual disease, the role of signal transduction abnormalities in leukemia, and the construction of gene-expression profiles of response and progression.
  • Rajan Lab
    Basic Sciences
    Investigating mechanisms that enable energy homeostasis
  • Randolph Lab
    Public Health Sciences
    The Randolph Program's research focuses on mathematical and statistical methods for high-dimensional, functional and otherwise "non-standard" data including: image-based data, mass spectrometry, various spectroscopies, microbiome and genetic arrays as well as longitudinal data. Projects and collaborations involve studies for discovery and validation of molecular properties and markers of disease.
  • Reid Lab
    Public Health Sciences, Human Biology
    The Reid Lab is focused on understanding the mechanisms by which environmental exposures (i.e. aspirin or other nonsteroidal antiinflammatory agents) affect the evolution of clones that lead to the development of esophageal adenocarcinoma in patients with Barrett's esophagus.
  • Research Cell Bank
    Clinical Research
    The Research Cell Bank (RCB) is a qualified, experienced research facility that has been actively engaged in clinical research through B-lymphoblastoid cell (B-LCL) transformation and maintenance, DNA extraction, and inventory control for more than 30 years. The RCB is currently expanding its role as a core repository of reagents and services to better serve the needs of investigators worldwide.
  • Riddell Lab
    Clinical Research
    Elucidating how T cells recognize cancer cells and pathogens and how to safely enhance T cell immunity to better control, cure and potentially prevent malignancies and serious viral infections.
  • Robins Lab
    Public Health Sciences
    Our research is computationally based and focuses on the adaptive immune system and its response to cancer and viral infection.
  • Rongvaux Lab
    Clinical Research
    The Rongvaux Lab studies the innate immune response, the very first steps in the development of the immune response, after exposure to a pathogen or formation of a tumor.
  • Roth Lab
    Basic Sciences
    The Roth Lab studies suspended animation and metabolic hibernation as a means to temporarily halt, or "dial down," metabolism. One day such techniques may help to buy time for critically ill patients on organ-transplant lists and in trauma situations.
  • Saha Lab
    Human Biology
    Conducts translational research focused on intrahepatic cholangiocarcinoma, a common form of liver cancer
  • Salama Lab
    Public Health Sciences, Human Biology
    The Salama lab studies the gastric bacterial pathogen Helicobacter pylori, which infects half the world's population and can cause ulcers and gastric cancer.
  • Schiffer Group
    Vaccine and Infectious Disease
    The Schiffer Group aims to gain a better understanding of the quantitative features of human pathogens and immune responses. In close collaboration with colleagues at the Fred Hutchinson Cancer Research Center and the University of Washington, the Group designs mathematical models that capture growth and decay kinetics of infectious organisms. These models attempt to replicate detailed empirical datasets, and in turn are used to inform subsequent human studies and laboratory experiments.
  • Shadman Group
    Clinical Research
    The Shadman Group's research focuses on studying epidemiology of hematologic neoplasms; and the association between autoimmune disorders, allergy and asthma and hematologic malignancies.
  • Shou Lab
    Basic Sciences
    The Shou Lab uses experimental biology, mathematics and engineering to study a variety of biological problems. Research interests include how cooperative systems evolve despite threats from "cheaters" that consume benefits without paying a fair cost, and how cells cope with nutrient limitations.
  • Simon Lab
    Clinical Research
    Research is focused on the development of new anticancer drugs through a wide range of experimental techniques and systems, ranging from organic synthesis to genetic screens. The compounds being studied have been identified from large collections of synthetic, drug-like compounds and from natural sources.
  • Smith Lab
    Basic Sciences
    The Smith Lab works to understand how genetic recombination and DNA repair are accomplished, and how they are regulated to occur at the proper place and time. As deviations in this process can result in birth defects and cancers, this work may lend insight into the causes of these diseases and ways of predicting or preventing them.
  • Spies Lab
    Clinical Research
    The Spies Lab focuses on experimental studies of the human NKG2D lymphocyte receptor and its ligands, and the mechanisms whereby these proteins stimulate or suppress immune responses against cancer and in autoimmune disease.
  • Stamatatos Lab
    Vaccine and Infectious Disease
    The Stamatatos group works towards the development of a safe and effective vaccine against HIV-1. Our major emphasis is the design of protein immunogens that would induce the production of neutralizing antibodies against diverse HIV-1 strains (commonly referred to as ‘broadly neutralizing antibodies’).
  • Stephan Lab
    Research focused on gastrointestinal cancer prevention, including genetic and clinical predisposition, chemoprevention, and early detection.
  • Stirewalt Lab
    Clinical Research
    The Stirewalt Lab is using AML as a prototype to explore the relationship of aging and malignant transformation, and how aging may be changing the biology of the hematopoietic diseases in older adults.
  • Stoddard Lab
    Basic Sciences
    The Stoddard Lab studies the structure and mechanism of enzymes, the body's catalysts of biological reactions, in order to harness them for use in biotechnology and medicine. The engineering and redesign of certain enzymes could be used in targeted therapies for genetic diseases such as hemophilia and cystic fibrosis.
  • Storb Lab
    Clinical Research
    Transplantation Biology combines basic and translational research directed at understanding and eliminating major barriers to successful allogeneic hematopoietic stem cell transplantation; these include host-versus-graft reactions, graft failure, acute and chronic graft-versus-host disease (GVHD), regimen-related toxicities, and induction of graft-versus-tumor reactions. The program’s goal has been to use stem cell transplantation to treat patients with malignant and nonmalignant hematologic diseases.
  • Strong Lab
    Basic Sciences
    The Strong Lab analyzes the structure of proteins and protein-receptor complexes that control the immune system's response to disease. Building on the principles learned from these studies, they also participate in a collaborative project to design proteins for a vaccine to prevent AIDS.
  • Subramaniam Lab
    Basic Sciences
    Research aims to understand the molecular mechanisms and cellular design principles that enable this tight regulation.
  • Sun Lab
    Statistical/computational methods and software packages for different types of omic data, including array or sequencing data for germline/somatic point mutations, copy number alterations, DNA methylation, and gene expression.
  • Taniguchi Lab
    Public Health Sciences, Human Biology
    The Taniguchi Lab's long-term research objective is to elucidate molecular mechanism of DNA damage response pathways, such as the Fanconi Anemia-BRCA (FA-BRCA) pathway, and their involvement in carcinogenesis.
  • Tapscott Lab
    Clinical Research, Human Biology
    The Tapscott Lab studies gene transcription and expression in normal development and disease, with an additional emphasis on rhabdomysarcomas (cancers with characteristics of skeletal muscle) and human muscular dystrophies. Other research areas include gene and cell therapies for muscular dystrophy, and the biology of triplet repeats and their associated diseases.
  • Taylor Lab
    Vaccine and Infectious Disease
    The Taylor lab aims to inform vaccine design by gaining a deeper understanding about the mechanisms limiting the generation of a protective B cell response.
  • Thompson Studies
    Public Health Sciences
    Led by Dr. Beti Thompson, this research group works to understand why disparities in cancer incidence and survival rates exist among different populations, especially Latinos. The group also supports efforts to reduce other health disparities, including diabetes and pesticide exposure, in minority communities in the United States and abroad.
  • Till Lab
    Clinical Research
    Translational research on chimeric antigen receptor (CAR) T cells and assessing the function of CAR T cells targeting CD20 and CD19 in vitro and in mouse models, including correlative assays investigating the development of endogenous anti-tumor immune responses following CAR T cell therapy
  • Tobacco & Health Behavior Science Research Group
    Public Health Sciences
    This group, led by Dr. Jonathan Bricker, focuses on two key questions: (1) Can innovative theory-based behavioral interventions succeed in changing unhealthy behaviors (e.g., smoking)?; (2) Why do people engage in unhealthy behaviors (e.g., smoking)?
  • Tsukiyama Lab
    Basic Sciences
    The Tsukiyama Lab studies chromatin, the complex of DNA and proteins that make up our chromosomes, and how chromatin structure controls essential processes that take place on DNA.
  • Turtle Lab
    Clinical Research
    The Turtle Laboratory in the Fred Hutch Program in Immunology is focused on understanding the characteristics of distinct subsets of human T cell subsets, their potential utility for tumor immunotherapy and their role in immune reconstitution after HCT.
  • Vasioukhin Lab
    Human Biology
    The Vasioukhin lab studies the mechanisms and significance of cell polarity and cell adhesion in normal mammalian development and cancer. In addition, we have a significant interest in the mechanisms responsible for initiation and progression of human prostate cancer. We believe that it is important to study cells in their normal microenvironment.
  • Vaughan Group
    Public Health Sciences
    Focus of research is the identification of environmental and host factors that underlie this dramatic increase in incidence. We have approached this through population-based case-control studies of cancer, community-based case-control studies of newly diagnosed Barrett’s, and a long-standing cohort study of persons with Barrett’s.
  • Walter Lab
    Clinical Research
    Research is focused on clinical trials testing new drugs and drug combinations to treat acute myeloid leukemia.
  • Warren Lab
    Clinical Research
    The Warren Lab studies human antitumor immune responses at the cellular and molecular level in order to learn how these immune responses can be exploited to treat human cancer.
  • Wu Group
    Public Health Sciences
    The development and application of statistical methods for translational science and particularly for analysis of high-dimensional genomic data within the broader context of clinical trials as well as population-based genetic, gene-environment interaction, epigenetic, microbiome, and metabolomic studies.
  • Zheng Lab
    Public Health Sciences
    Research interests are in the statistical methods for longitudinal data with time-to-event outcome, with a focus on using semi-parametric methods for estimating time-dependent ROC curves which are useful for evaluating the ability of longitudinal biomarkers or algorithms to identify cancer early, or signal disease prognosis.