Syracuse University, 2002, BS Biology
Dartmouth Medical School, 2006, MD
Dartmouth-Hitchcock Medical Center, 2006-2009, Internal Medicine Residency
Dartmouth-Hitchcock Medical Center, 2009-2010, Chief Medical Resident
University of Washington, 2010-2013, Pulmonary and Critical Care Medicine fellow
Idiopathic Pneumonia Syndrome (IPS) includes all non-infectious lung injury that occurs after hematopoietic cell transplantation. Studies from 2008 and prior report IPS occurring after 3-15% of hematopoietic cell transplants. IPS has no universally-effective therapies resulting in poor outcomes. To develop effective preventive and therapeutic strategies, we need to better understand factors that predispose patients to IPS and contribute to the development of IPS.
My prior research shows that the risk of IPS within 120 days of allogeneic hematopoietic cell transplantation increases with the number of red blood cell and platelet transfusions the patient receives. Two lines of inquiry arose from this work. First, I am updating our knowledge of factors that increase the risk of IPS in the contemporary era of transplantation medicine. In a future project, I will examine biomarkers from the lung compartment of patients with IPS in effort to elucidate its biology. My second research interest is the potential role of blood component transfusions in lung injury. Blood transfusions are life-saving in some circumstances but may mechanistically contribute to lung injury in some critically ill patients. Adaptations in blood component production and allocation may mitigate this risk. To better understand potential mechanisms linking blood transfusions to lung injury, I am presently examining relationships between transfusion of anti-leukocyte antibodies and respiratory failure in a cohort of critically ill trauma patients.
Epidemiology of Idiopathic Pneumonia Syndrome in patients who underwent allogeneic hematopoietic cell transplantation at Seattle Cancer Care Alliance between 2006 and 2013
Associations between transfusion of antibodies against Human Leukocyte Antigen I/II and Human Neutrophil Antigen and acute respiratory distress syndrome after severe blunt trauma
Leukocyte expression profiles in the pulmonary compartment of patients with pulmonary complications of hematopoietic cell transplantation
Kinsler E, Vande Vusse LK, Malone M, Zacharski L, Whiteside J. Pelvic Organ Prolapse with Hypermobility Syndrome and Operative Bleeding Managed with Aprotinin. J Pelvic Med Surg 2008;14(1):65-8. doi: 10.1097/SPV.0b013e3181633a21
Vande Vusse LK, Zacharski L, Dumas M, McKernan L, Cornell C, Kinsler E, Whiteside J. Prohemostatic Therapy: The Rise and Fall of Aprotinin. Semin Thromb Hemost Apr 2010;36:103–12. PMID: 20391301
Parsons EC, Kross EK, Vande Vusse LK, Watkins TR, Caldwell ES. Heckbert SS, Ali NA, Hough CL. Red blood cell transfusion is associated with decreased in-hospital muscle strength among critically ill patients requiring mechanical ventilation. J Crit Care. 2013 Dec;28(6):1079-85. PMID: 23937968
Vande Vusse LK, Madtes DK, Guthrie KA, Gernsheimer TB, Curtis JR, Watkins TR. The association between red blood cell and platelet transfusion and subsequently developing idiopathic pneumonia syndrome after hematopoietic stem cell transplantation. Transfusion. Apr 2014:54(4):1071-1080. PMID:24033082; PMCID: PMC4059041
Peltan ID, Vande Vusse LK, Maier RV, Watkins TR. An INR-based definition of acute traumatic coagulopathy is associated with mortality, venous thromboembolism, and multiple organ failure after injury. Crit Care Med. 2015 Jul;43(7):1429-38. PMID: 25816119
Vande Vusse LK, Caldwell E, Tran E, Hogl L, Dinwiddie S, Lopez JA, Maier RV, Watkins TR. The epidemiology of transfusion-related acute lung injury varies according to the applied definition of lung injury onset time. Ann Am Thorac Soc. 2015 Jun 23 [Epub]. PMID: 26102516