The overarching theme of Dr. Luebeck's research is to bridge the widening gap between cancer biology and population sciences. Over the years he and his team have developed bio-mathematical descriptions of carcinogenesis (primarily in colon, lung, pancreas and Barrett's esophagus) that help identify and characterize relevant spatio-temporal scales of neoplastic progression and their impact on cancer incidence. From these descriptions Dr. Luebeck has derived quantitative methods for the analysis of both experimental and epidemiological data, including data on precursor lesions from screening studies.
The ultimate goal is to be able to model/optimize the benefits of cancer screening, prevention, and intervention - based on a biological description of the natural history of cancer. For more information on this subject, please visit NCI CISNET and NCI ICPB.