Medical College of Wisconsin, 1994, PhD (Biochemistry)
Medical College of Wisconsin, 1995, MD
I am interested in how abnormal cell cycle regulation impacts cell proliferation, differentiation and stem cell maintenance focusing on myeloid disorders including myelodysplastic syndrome, myeloproliferative neoplasm and acute myeloid leukemia. Our current focus is on erythroid maturation using a function shRNA study to challenge cell cycle exit during erythropoiesis and studying erythroleukemia arising from a Sleeping Beauty transposon mediated insertional mutagenesis study. Newer studies focus on megakaryocytic differentiation and stem cell maintenance in cell cycle
My clinical service specializes in bone marrow transplant Pathology including accessing hematologic malignancy, graft-vs-host disease and infection in stem cell transplant patients.
1. Characterization of megakaryocytic differentiation in myeloproliferative neoplasms
2. The role of CDK2 inhibitory phosphorylation on stem cell maintenance