McGarry Houghton, MD

McGarry Houghton, MD

Associate Professor, Division of Pulmonary and Critical Care Medicine
University of Washington


Johns Hopkins University, 1992, BA (Chemistry)
Georgetown University, School of Medicine, 1996, MD
Intern, Internal Medicine, UT-Southwestern (Parkland Hospital), Dallas, TX, 1997
Resident, Internal Medicine, UT-Southwestern (Parkland Hospital), Dallas, TX, 1999
Fellow, Pulmonary & Critical Care Medicine, Washington University School of Medicine, St. Louis, MO 2004

Research Focus:

The Houghton Lab studies the immune cell composition and function in solid tumor malignancies, most prominently in non-small cell lung cancer (NSCLC). The group has established a platform to combine the study of human tissue specimens and mouse models of cancer to address key questions ranging from mechanisms of immune escape and treatment failures to the identification of novel biomarkers for lung cancer early detection. This platform has revealed an essential role for myeloid lineage cells—particularly neutrophils—in excluding tumor-reactive lymphocytes from the malignant portion of tumors. The current focus of the lab is to determine the mechanistic basis of lymphocyte-excluded NSCLCs and to develop therapeutic strategies to circumvent their exclusion.

Clinical Expertise:

Dr. Houghton is a Pulmonary and Critical Care physician by training, with a clinical interest in lung cancer diagnosis. We have a robust clinical program in pulmonary nodule evaluation and early lung cancer detection.

Current Studies:

  • Immune cell composition and function within the tumor microenvironment
  • Contribution of neutrophil lineage cells to NSCLC growth and invasiveness
  • Lung cancer early detection

Additional Links & Information

Related Labs & Projects

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McGarry Houghton, MD

Contact Information

(206) 667-3175
(206) 667-5255
Additional contact

Mail Stop: D4-100