McGarry Houghton, MD

Associate Member
Clinical Research Division
Associate Member
Human Biology Division
Associate Professor, Division of Pulmonary and Critical Care Medicine
University of Washington


Johns Hopkins University, 1992, BA (Chemistry)
Georgetown University, School of Medicine, 1996, MD
Intern, Internal Medicine, UT-Southwestern (Parkland Hospital), Dallas, TX, 1997
Resident, Internal Medicine, UT-Southwestern (Parkland Hospital), Dallas, TX, 1999
Fellow, Pulmonary & Critical Care Medicine, Washington University School of Medicine, St. Louis, MO 2004

Research Focus:

The initial focus of our group was to study the role of inflammatory cell derived proteinases in diseases occurring within the lungs. To date, this has included novel findings for many disease processes including lung cancer, COPD/emphysema, acute lung injury, pulmonary infections, and pulmonary fibrosis. More recently, our focus has shifted to the tumor microenvironment. We are currently investigating the role of innate immune cells within the tumor microenvironment in a comprehensive fashion, beginning with how they have been recruited, and ending with a detailed understanding of the mechanism by which a specific immune cell effector has impacted lung tumor growth.

Since moving to the Fred Hutch last year, we have expanded our work to include an investigation of the lymphocytes subsets that augment myeloid cell recruitment to the lung, and the impact that these myeloid cells have on cytotoxic lymphocyte function. Using a combination of mouse models of lung cancer and human NSCLC specimens, we have been able to determine the exact composition of the immune response to lung cancer, and hope to identify novel therapeutic targets that would improve the ability of tumor infiltrating immune cells to effectively combat cancer.

Clinical Expertise:

Dr. Houghton is a Pulmonary and Critical Care physician by training, with a clinical interest in lung cancer diagnosis. We have a robust clinical program in pulmonary nodule evaluation and early lung cancer detection.

Current Studies:

R01 HL108979-03 (Houghton) 07/15/11 - 06/30/16
Neutrophil Elastase Links Idiopathic Pulmonary Fibrosis and Lung Cancer
The purpose of this proposal is to establish neutrophil elastase as a legitimate therapeutic target for patients with lung cancer and/or pulmonary fibrosis.

R01 HL107883-03 (Reilly) 07/01/11 - 04/30/15
NIH / NHLBI / University of Pittsburgh
The Emphysematous Microenvironment Promotes Lung Tumorigenesis and Progression
The research proposed in this application is designed to test the hypothesis that the development of emphysema is associated with a microenvironment in the lung that fosters the development and growth of lung cancer.

Related Labs & Projects

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Contact Information

(206) 667-3175
(206) 667-5255
Additional contact

Mail Stop: D4-100