Brandon K. Hadland, MD, PhD

Brandon K. Hadland, MD, PhD

Assistant Member, Pediatric Oncology and Stem Cell and Gene Therapy Programs, Integrated Immunotherapy Research Center
Clinical Research Division

Education/Training

  • Harvey Mudd College, Claremont, CA; B.S., Chemistry, 1998
  • Washington University School of Medicine, Saint Louis, MO; M.D., Ph.D. in Molecular Cell Biology, 2006
  • Seattle Children’s Hospital/University of Washington School of Medicine, Department of Pediatrics, Seattle, WA; Pediatrics Internship, 2006-2007; Pediatrics Residency, 2007-2009
  • Seattle Children’s Hospital/University of Washington School of Medicine/Fred Hutchinson Cancer Research Center, Department of Pediatrics, Division of Hematology/Oncology, Seattle, WA; Pediatric Hematology/Oncology Fellowship, 2009-2012
  • Fred Hutchinson Cancer Research Center, Clinical Research Division, Seattle, WA; Research Associate, 2012-2018
  • U. of Washington School of Medicine, Department of Pediatrics, Division of Hematology/Oncology; Acting Instructor, 2012-2016                           
  • U. of Washington School of Medicine, Department of Pediatrics, Division of Hematology/Oncology; Acting Assistant Professor, 2016-2018

Research Focus

Dr. Hadland’s research is focused on understanding the factors that control the formation of the “hematopoietic” stem cells that give rise to blood and immune cells. He is harnessing new technologies to simultaneously analyze gene activities across the many different cell types within the special “hematopoietic stem cell niche,” the physical site within which the stem cells evolve, and to characterize interactions between the various cells. He aims to identify the specific biological signals that trigger the formation of blood stem cells. His ultimate goal is to use new findings to develop a system for generating and cultivating blood stem cells in the lab, providing an invaluable resource for research and enabling studies of novel treatments to cure  diseases including hematologic cancers and inherited blood and immune disorders.

Specific research foci include:

  • Role of Notch and other signal pathways in embryonic hematopoietic stem cell development,
  • Analysis of the hematopoietic niche during hematopoietic stem cell emergence, using single cell functional and molecular techniques,
  • Laboratory platforms for engineering hematopoietic stem and progenitor cell development,
  • Directed differentiation of murine and human pluripotent stem cells (that can make many different cell types) to selectively hematopoietic stem and progenitor cells, and
  • Development of certain (“innate-like”) immune cells during embryonic hematopoiesis

Clinical Expertise

Dr. Hadland is a hematologist/oncologist and stem cell transplantation expert who treats young patients in the Seattle Children’s Hospital transplant service.

 



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Brandon K. Hadland, MD, PhD

Contact Information

Phone
(206) 667-1095
Fax
(206) 667-6084
Email
Additional contact

Mail Stop: D2-100

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