Cancer Prevention Program
The objective of this nested case-control study is to elucidate mechanisms by which Vitamin D influences prostate cancer risk among 18,000 participants in the Prostate Cancer Prevention Trial (PCPT). Strong evidence from experimental studies indicates that vitamin D is involved in key carcinogenesis-related processes, including gene transcription, cellular differentiation, T-cell mediated immunity, cell cycle control, proliferation and apoptosis. We assayed baseline blood samples for serum concentrations of 25(OH)D and polymorphisms in a set of vitamin D related metabolizing genes. Prostate cancer outcomes were ascertained by biopsy in both cases and non-cases as part of the primary PCPT protocol.