CORE Family Studies

Seattle Colon Cancer Family Registry Cohort

Research Publications

Dr. Newcomb, the Principal Investigator of the Seattle CCFRC has done extensive research in the areas of breast and colon cancer. In preparing the manuscripts which you can locate via the link below, she works with researchers within the Hutchinson Center and around the world. She is a prolific author, demonstrating her commitment to reporting research findings in peer-reviewed journals so that others can take advantage of what is being learned about the causes and treatment of breast and colon cancer.  Read more about Dr. Newcomb on her faculty profile or scientific profile.

Feature Articles

Colorectal and other cancer risks for carriers and noncarriers from families with a DNA mismatch repair gene mutation: a prospective cohort study.
Journal of Clinical Oncology. March 20, 2012; Volume 30(9): pages 958-64.
A study concluding Lynch Syndrome (a pattern of symptoms resulting in a higher incidence of colorectal and certain other cancers) increases the risk of developing colorectal and six other types of cancer.
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Prediagnostic smoking history, alcohol consumption, and colorectal cancer survival:  the Seattle Colon Cancer Family Registry.
Cancer. November 1, 2011; Volume 117(21): pages 4948-57.
A study showing people who smoked at the time of colorectal cancer diagnosis were more likely to die of the cancer, especially if their tumors showed a common feature seen in tumors of people with Lynch syndrome. Read the article >

Prediagnostic non-steroidal anti-inflammatory drug use and survival after a diagnosis of colorectal cancer.
Gut. April, 2011; Volume 60(4): pages 491-8.
A study concluding people taking non-steroidal anti-inflammatory drugs (NSAIDs) at the time of their colorectal cancer diagnosis had a better disease outlook than people who were not regular NSAID users.
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