Advanced Colorectal Cancer of Serrated Subtype (ACCESS) Study

Cancer Prevention Program

Advanced Colorectal Cancer of Serrated Subtype (ACCESS) Study

Welcome to the ACCESS study website!

Photo by iStock

Advanced Colorectal Cancer of Serrated Subtype (ACCESS) is federally sponsored by the National Cancer Institute within the National Institutes of Health. Fred Hutch researchers are leading this innovative research project, studying a subtype of colorectal cancer (CRC) that develops via the serrated pathway. Our goal is to help inform future prevention strategies and to advance treatment for CRC, ultimately leading to improved patient survival. ACCESS is composed of the Puget Sound Colorectal Cancer Cohort (PSCCC) and includes more than 4,000 people diagnosed with colorectal cancer.

What is a serrated pathway?

The serrated pathway is one of the ways CRC can develop. About 20-30 percent of all CRCs are a part of this serrated pathway, with previous research showing that this subtype of cancer results in poorer prognosis and is more difficult to prevent due to its quick progression or inability to be caught during screening. There is also research that suggests differences in tumor stage and anatomic site between serrated CRC and non-serrated CRC, indicating importance of learning more about the serrated pathway.

Study goals

This project has 3 specific aims:

  • Identify germline genetic variants associated with risk of serrated CRC and compare those variants to ones associated with non-serrated CRC.

  • Compare the presentation of serrated CRC to non-serrated CRC with respect to clinical and pathological features, such as CRC screening history, stage, anatomic site, histologic type, and grade.

  • Compare the survival associated with serrated CRC and non-serrated CRC, accounting for potential differences in treatment.

For Participants

If you are an ACCESS Study research participant and would like more information about your involvement, please visit Participant Information.

How we will use the information gathered

The information gathered in the ACCESS study will allow us to compare the serrated pathway of CRC with other types of CRC, in order to better improve prevention and treatment options available for individuals. These improvements will hopefully help to decrease side effects and increase quality survival among CRC survivors.