Advanced Colorectal Cancer of Serrated Subtype (ACCESS) is federally sponsored by the National Cancer Institute within the National Institutes of Health. Fred Hutch researchers are leading this innovative research project, studying a subtype of colorectal cancer (CRC) that develops via the serrated pathway. Our goal is to help inform future prevention strategies and to advance treatment for CRC, ultimately leading to improved patient survival. ACCESS is composed of the Puget Sound Colorectal Cancer Cohort (PSCCC) and includes more than 4,000 people diagnosed with colorectal cancer.
What is a serrated pathway?
The serrated pathway is one of the ways CRC can develop. About 20-30 percent of all CRCs are a part of this serrated pathway, with previous research showing that this subtype of cancer results in poorer prognosis and is more difficult to prevent due to its quick progression or inability to be caught during screening. There is also research that suggests differences in tumor stage and anatomic site between serrated CRC and non-serrated CRC, indicating importance of learning more about the serrated pathway.