Public Health Sciences Labs & Projects

Labs & Projects

The largest of the Center's Divisions, Public Health Sciences (PHS) is organized into five distinct scientific programs, each with its own research focus and faculty. 

The following list of projects is representative of the wide-array of public health research currently underway at the Center.

  • A Pragmatic Trial to Improve Colony Stimulating Factor Use in Cancer (TrACER)
    Public Health Sciences
  • Affinity Based Serum Proteomics: Breast and Ovarian Cancer
    Public Health Sciences
  • Ancillary Cost-Effectiveness Analysis (BMT CTN 1101)
    Public Health Sciences
  • Asia Cohort Consortium
    Public Health Sciences
    The Asia Cohort Consortium (ACC) is a collaborative effort seeking to understand the relationship between genetics, environmental exposures, and the etiology of disease through the establishment of a cohort of at least one million healthy people around the world.
  • Bielas Lab
    Public Health Sciences, Human Biology
    The Bielas Lab studies the fundamental and clinical implications of nuclear and mitochondrial DNA mutations in the development of cancer and age-related disease. Translational research projects explore the potential utility of these mutations as novel DNA biomarkers for improved disease detection, treatment outcome, survival and quality of life.
  • Biomarkers For Ovarian Cancer Diagnosis and Screening
    Public Health Sciences
  • BRAVO Study
    Public Health Sciences
    The purpose of the BRAVO Study is to understand what causes different types of breast cancer. It will include women who have experienced breast cancer, from age 20 to age 69, living in Washington state and New Mexico.
  • Breast Cancer and HRT: Genetic Susceptibility within the Progesterone Pathway
    Public Health Sciences
  • Breast Cancer Risk and Molecular Change After Chernobyl
    Public Health Sciences
    This study has two primary aims: 1) to investigate whether the risk of premenopausal breast cancer is associated with individual radiation dose to the breast from the Chernobyl accident, to estimate the risk per unit dose, to investigate the shape of the dose- response, and potential dose effect modifying factors, including molecular characteristics and established breast cancer risk factors; and 2) to investigate whether the association of breast cancer risk with radiation exposure differs according to characteristics of breast cancer, including hormone receptor status, genomic loss and gain, and specific alterations in 14 selected DMA repair genes.
  • Breast Health Global Initiative
    Public Health Sciences
    The Breast Health Global Network (BHGI) is striving to improve breast health outcomes and access to breast cancer screening, detection and treatment for women in low- and middle-income countries.
  • C-erbB-2 and Risk of Contralateral Breast Cancer
    Public Health Sciences
    This Career Development Award expands Dr. Li's previous work on contralateral breast cancer (CBC).
  • Cancer Epidemiology Research Cooperative (CERC)
    Public Health Sciences
    Our studies focus on the causes of cancer, cancer prevention, factors associated with cancer survival, and the effects of cancer on the quality of life.
  • Cancer Surveillance System
    Public Health Sciences
    The Cancer Surveillance System (CSS) collects population-based data on cancer incidence and survival in 13 counties in western Washington State. These cancer data are collected to provide public health scientists and practitioners with the ability to track trends in the incidence of all forms of cancer (surveillance); identify and investigate patterns of cancer occurrence (epidemiology); and monitor of trends in mortality and survival for specific cancers (end results).
  • CAREGEN: Genetic susceptibility and the risk of breast cancer
    Public Health Sciences
    This is an ancillary study of the NICHD Women’s CARE Study, a large population-based multi-center case-control study among Caucasian and African-American women that is designed primarily to evaluate the risk of breast cancer in women ages 35-64 in relation to oral contraceptive (OC) use and hormone replacement therapy (HRT).
  • Carlson Group
    Public Health Sciences
    The Carlson Group uses genetic epidemiology to investigate the genetic risk factors of diseases such as cancer, cardiovascular and neurological disease. The group identifies statistical correlations between variations and disease. The group's molecular biology laboratory is then equipped to assess the molecular mechanisms behind these correlations. Recently, the lab has played a significant role in development of technologies for adaptive immune system profiling, in collaboration with Harlan Robins and Hootie Warren. These tools are being applied to a variety of arenas.
  • Carotene and Retinol Efficacy Trial (CARET)
    Public Health Sciences
  • Ceballos Studies
    Public Health Sciences
    The group's research emphasizes the development of culturally-appropriate interventions, the inclusion of community collaboration in research, and use of biobehavioral methods to assess program effectiveness.
  • Center for the Evaluation of Biomarkers for the Early Detection of Breast Cancer
    Public Health Sciences
  • Chen Lab
    Public Health Sciences
    The Chen Lab's goal is to understand the molecular epidemiology and etiology of oral, lung and endometrial cancers.
  • Cheung Lab
    Public Health Sciences
    The major focus of the Cheung laboratory is to understand the cellular and molecular mechanisms by which tumor cell clusters invade and metastasize to distant sites.
  • CHIIP Study
    Public Health Sciences
    The Communicating Health Information and Improving Coordination with Primary Care (CHIIP) study is to determine the burden of potentially modifiable cardiovascular risk factors in survivors of childhood cancer at risk for early heart disease.
  • Ching-Yun Wang Group
    Public Health Sciences
    Research is centered on measurement error, missing data, physical activity and dietary intake data, joint modeling of survival and longitudinal data, and analysis of clinical trials.
  • Clinical and Economic Value of Next Generation Sequencing-Based Diagnostic Testing in Cancer Care
    Public Health Sciences
  • Cocoa Supplement and Multivitamin Outcomes Study (COSMOS)
    Public Health Sciences
    The Women’s Health Initiative will be conducting a five-year, large-scale randomized controlled trial to test the effect of a concentrated cocoa extract and multivitamin supplements in reducing risks of CVD and cancer.
  • ColoCare Consortium
    Public Health Sciences
  • COMIDAS Study
    Public Health Sciences
    The COMIDAS study will compare the metabolic response between traditional Mexican diets vs. Western diets.
  • COMIDAS Study – Project 2 in Understanding and Preventing Breast Cancer Disparities in Latinas
    Public Health Sciences
  • Comprehensive Center for the Advancement of Scientific Strategies (COMPASS)
    Public Health Sciences
  • CORE Family Studies
    Public Health Sciences
    This international registry provides a comprehensive infrastructure for facilitating interdisciplinary studies in the genetic epidemiology of colorectal cancer
  • Cost Effectiveness Analysis of Stem Cell Transplant in Older MDS Patients (BMT CNT 1102)
    Public Health Sciences
  • Depo-Provera and Breast Cancer: Epidemiology and Pathology
    Public Health Sciences
    The primary objective of this study is to assess the relationship between DMPA use and breast cancer risk among young women in a large population-based study.
  • Descriptive Epidemiology and Clinical Course of Myelodysplastic Syndromes (MDS) within the Group Health Cooperative
    Public Health Sciences
    An epidemiologic study using patient databases from the Group Health Cooperative to estimate basic descriptive statistics for myelodysplastic syndromes (MDS) (e.g., incidence, prevalence, survival) and to track patterns of treatment for the disease.
  • Diagnostic and Biomarkers Statistical (DABS) Center
    Public Health Sciences
  • Diet and genetic risk for prostate cancer (Results from Carotene and Retinol Efficacy Trial = CARET)
    Public Health Sciences
  • DOVE Study
    Public Health Sciences
    The purpose of the DOVE Study is to further our understanding of why some women develop ovarian tumors and others do not. The results of this study will help to improve the health of future generations of women.
  • Early Detection Research Network (EDRN)
    Public Health Sciences
  • Energy Balance, Organochlorine Exposure, and Possible Toxicologic Effects
    Public Health Sciences
    The study builds on resources from an existing randomized controlled trial of exercise, with an extensive assessment of immune function biomarkers.
  • Epidemiology and Biostatistics Training
    Public Health Sciences
    Provide skills in epidemiology and biostatistics that will enable the trainee to address this problem through the conduct of high quality cancer research.
  • Etzioni Lab
    Public Health Sciences
    The Etzioni Lab focuses on statistical methods for prostate-cancer studies, with the goal of improving guidelines for screening and treatment. Etzioni has assessed the likely impact of prostate-specific antigen testing on prostate-cancer incidence and mortality, and developed approaches for evaluating new cancer-screening biomarkers.
  • EXCEL Study
    Public Health Sciences
    The ExCel research study is a breast cancer prevention clinical trial. It is an important international clinical trial designed to determine whether a special type of medication can prevent breast cancer in healthy postmenopausal women who are at an increased risk for developing breast cancer.
  • Factors Affecting Survival of Young Breast Cancer Patients
    Public Health Sciences
    This study seeks to identify factors that affect the risk of recurrence and death in a cohort of 1400 women diagnosed with invasive breast cancer before age 45.
  • Galloway Lab
    Human Biology, Public Health Sciences
    The Galloway Lab studies the mechanisms by which human papillomaviruses contribute to cancer, with an emphasis on types most likely to progress to cervical cancer. They work to understand the natural history of genital HPV infections and why only a small subset of women infected with high-risk HPVs develop cancer.
  • Genetics and Epidemiology of Colorectal Cancer Consortium (GECCO)
    Public Health Sciences
  • Genome-Wide Association Study in Early-Onset Breast Cancer
    Public Health Sciences
    This study aims to conduct a genome-wide association study of young (less than 50 years) invasive female breast cancer to identify new genes responsible for young cases who are negative for BRCA1 and BRCA2 gene mutations.
  • Geographic Clustering of Myelodysplastic Syndromes (MDS) and Correlation with Pollution Sources
    Public Health Sciences
    This study constitutes one of the first large population-based investigations of incidence patterns of myelodysplastic syndromes (MDS) in the United States.
  • Halloran Group
    Vaccine and Infectious Disease, Public Health Sciences
    The Betz Halloran group does research on study designs and analytic methods for evaluating vaccines in populations. Research includes developing new methods as well as applying existing methods to novel applications.
  • Health and Behavioral Innovations in Technology (HABIT)
    Public Health Sciences
    The Health and Behavioral Innovations in Technology (HABIT) research group designs, develops, tests technology-delivered interventions for health behavior change.
  • Health Communication Research Center
    Public Health Sciences
    The goal of HCRC is to develop, test, evaluate, and disseminate theory-based health communication interventions using various media including prints, podcasts, internet websites, and social media.
  • Health Disparities Research Center
    Public Health Sciences
  • Health Effects of Sugar-Sweetened Beverages Study
    Public Health Sciences
    Fred Hutchinson Cancer Research Center is recruiting adults 18-65 years old to participate in a study that will investigate the health effects of sugar-sweetened beverages.
  • Health Effects of Vitamin D Study
    Public Health Sciences
    Healthy, overweight volunteers are needed for a Fred Hutchinson Cancer Research Center study that will investigate the health effects of vitamin D.
  • Health, Eating, Activity, and Lifestyle (HEAL) Study
    Public Health Sciences
    A study to investigate methods to improve breast cancer survival
  • Health, Eating, Activity, and Lifestyle (HEAL) Study
    Public Health Sciences
  • Herbold Computational Biology Program
    Public Health Sciences
    The Computational Biology Program at Fred Hutch brings a new generaton of biological researcher to the Hutch whose training in biology is accompanied by advanced training in quantitative sciences including physics, statistics, mathematics, and computer science.
  • Hsu Lab
    Public Health Sciences
    Research area is statistical genomics, including assessing familial aggregation using variable age at onset as disease outcomes, discovering latent genes via linkage and association techniques, and characterizing the effect of the genes and their interaction with environmental risk factors on the time course of the disease.
  • iCanQuit Study
    Public Health Sciences
  • Identification and Validation of Circulating Biomarkers of the Early Detection of Breast Cancer in Pre-clinical Specimens
    Public Health Sciences
    This study aims to are to use three proteomic platforms to identify protein biomarkers in preclinical sera that could potentially be used for the early detection of breast cancer.
  • Immune Exercise Study
    Public Health Sciences
  • INSIGHT Study
    Public Health Sciences
    The purpose of this study is to look for the possible causes of developing a second breast cancer among women who had an in situ breast cancer.
  • Integrated Discovery of Novel Markers in Hodgkin Lymphoma
    Public Health Sciences
  • IRIS Study
    Public Health Sciences
    The goal of the IRIS study is to enroll about 1,000 women with certain gynecologic conditions to share their medical history and provide a saliva sample, which contains genetic material. We want to better understand what medical, lifestyle, background, and genetic factors may be related to these conditions.
  • Kemp Lab
    Human Biology, Public Health Sciences
    The Kemp Lab seeks to identify the next generation of targeted anticancer agents. We use a combination of high throughput functional genomic and small molecule screens, and genomic analysis applied to a range of isogenic and patient derived tumor models. We are discovering and validating novel drug targets and therapeutic options for multiple solid tumor types including pancreatic, ovarian, head and neck and breast cancer.
  • Kensler Lab
    Public Health Sciences
    The Kensler Lab studies adaptive responses to endogenous and exogenous stress as targets for cancer prevention with a primary focus on the KEAP1-NRF2 signaling pathway.
  • Kooperberg Website
    Public Health Sciences
    Research is focused on the development of statistical methodologies and software for large public health studies.
  • Lampe Lab
    Public Health Sciences, Human Biology
    The Paul Lampe Lab attempts to discover early detection cancer biomarkers and investigates the control of cell growth at the cell biology level. Of particular interest is the role that gap junctions play in the regulation of cell growth and the cell cycle, and the disruption of this relationship during cancer development.
  • Li Lab
    Public Health Sciences
    Dr. Li uses a multidisciplinary approach to understand factors related to the causes and patient outcomes of breast cancer. Current projects include identifying new biomarkers that could be used for early detection, evaluating risk factors for different types of breast cancer, determining predictors of poor outcomes among breast cancer survivors, and assessing disparities in cancer stage, treatment and survival by race/ethnicity.
  • MacPherson Lab
    Human Biology, Public Health Sciences
    The MacPherson Lab is focused on understanding the mechanisms through which cancer-mutated genes drive tumorigenesis. The lab studies small cell lung cancer and other solid tumors. We generate novel genetically engineered mouse models that we use to interrogate the biology underlying major cancer driver genes. We are particularly interested in understanding epigenetic regulators that are genetically mutated in human tumors.
  • Madeleine Lab
    Public Health Sciences
    Dr. Madeleine's research focuses primarily on the molecular epidemiology of disease-causing agents, or pathogens, and the immune response to them that may be associated with cancer development and prognosis. Another interest is the role of chronic, undiagnosed immune system dysfunctions (such as those occurring with age, obesity, physical inactivity, hormone use, and UV exposure) in cancer development.
  • Markers of B-Cell Stimulation as Potential Predictors of Non-Hodgkin Lymphoma
    Public Health Sciences
    We are conducting a nested case-control study of biologic markers of a B-cell stimulatory host environment as predictors of B-cell NHL among 500 cases and 500 pair-matched controls from the WHI Observational Study (OS), among whom biologic samples were collected an average of 10 years before NHL diagnosis.
  • Matsen Group
    Public Health Sciences
    Research is focused on the development and application of evolutionary methods for molecular sequence data (i.e. DNA and RNA).
  • Metabolically Activated Macrophages in Obesity and Insulin Resistance
    Public Health Sciences
  • Migraine, Migraine Medication Use, and Breast Cancer Risk
    Public Health Sciences
  • Modeling Ovarian Cancer Screening for CEA
    Public Health Sciences
  • Molecular Change and Thyroid Cancer Risk After Chernobyl
    Public Health Sciences
    This study will investigate the occurrence and molecular characteristics of thyroid cancer in residents of the Bryansk Oblast of the Russian Federation who were up to 50 years of age at the time of exposure to radiation from the Chernobyl Power Station accident on April 26, 1986.
  • Molecular Epidemiology Lab
    Public Health Sciences
    The Molecular Epidemiology Lab provides investigators working on population-based studies with laboratory-based research expertise through a collaborative scientific relationship and supports epidemiological and clinical investigators at Fred Hutch and their collaborators at other institutions.
  • Molecular Epidemiology of Endometrial Cancer
    Public Health Sciences
    This study tests the hypotheses that the risk of developing endometrial cancer is related to variation in genes that encode for enzymes: 1) involved in the biosynthesis or catabolism of estrogens, or in the response to steroid hormones, and 2) that repair DNA damage generated during estrogen exposure.
  • Molecular Epidemiology of Lung Cancer
    Public Health Sciences
    A study determining whether polymorphisms of enzymes involved in the repair of smoking-induced DNA damage, namely those from the base excision (BER) and nucleotide excision repair (NER) pathways, are associated with risk of lung cancer.
  • Move and Moderate in Balance (MOVE'M): A TREC Worksite Health Study
    Public Health Sciences
    A study related to a diet and exercise regimen that individuals can follow to achieve balance in their energy intake and expenditure
  • Mpower Prostate Cancer Registry
    Human Biology, Public Health Sciences, Clinical Research
    Mpower prostate cancer registry is an online community for men who have been diagnosed with prostate cancer and their families and friends.
  • MsFLASH
    Public Health Sciences
    MsFLASH, based at Fred Hutch, is a network of researchers conducting clinical trials aimed at finding promising treatments for the most common symptoms of menopause.
  • MsFLASH Study
    Public Health Sciences
    We are currently recruiting women in Seattle and Minneapolis for a study to learn more about vaginal symptoms as women age. The study will compare two popular treatments for symptom relief — a vaginal moisturizer and a low dose estrogen tablet that is placed in the vagina.
  • Mueller Lab
    Public Health Sciences
    Dr. Mueller's research focuses on the roles of maternal, gestational, early life factors, and early environmental exposures in the occurrence of childhood cancer and autoimmune diseases. She also studies reproductive history in relation to cancer and cancer survival in women, and reproductive outcomes among male and female childhood cancer survivors.
  • Neuhouser Studies
    Public Health Sciences
    The Neuhouser Studies group, led by Marian Neuhouser, focuses on investigating the role of lifestyle factors, including nutrition, physical activity and energy balance/obesity and their relationship to the etiology and prevention of cancer.
  • Night Shift Workers and Hormone Levels in Men
    Public Health Sciences
    This study will be the first effort to assess the effects of night shift work on melatonin and the hormones of most interest in the etiology of prostate cancer.
  • Night Shift Workers and Hormone Levels in Women
    Public Health Sciences
  • NSAIDs and Other Medications in Prostate Cancer Etiology
    Public Health Sciences
    The objective of this study is to determine whether use of NSAIDs and other frequently used medications are associated with risk of prostate cancer.
  • Nutrition and Physical Activity Assessment
    Public Health Sciences
  • Nutrition Assessment Shared Resource (NASR)
    Public Health Sciences
    A resource that aids investigators in incorporating state-of-the-art dietary data collection methods into their studies
  • Oral Cancer: Molecular Profiles & Clinical Outcomes
    Public Health Sciences
    Our goals in this study are to determine whether: 1) The prognosis of OSCC patients is associated with tumor gene expression profiles; 2) OSCC tumor characteristics known to be related to patient outcome - such as stage and nodal status - are associated with tumor gene expression profiles; and 3) Tumor gene expression differs among invasive OSCC, pre-neoplastic oral squamous cell lesions, and normal oral tissue.
  • Overbaugh Lab
    Human Biology, Public Health Sciences
    The Overbaugh lab has a long-standing interest in understanding the mechanisms of HIV-1 transmission and pathogenesis. The lab is part of a larger team, comprising researchers in both Seattle and Kenya (The Nairobi HIV/STD Project). Trainees in the lab have opportunities to engage in studies of viral evolution, virus-host cell interactions, and viral immunology all within the context of international collaboration.
  • PACE [Promoting Activity and Changes in Eating] Project
    Public Health Sciences
    A project to develop simple strategies for moderating dietary intake and increasing energy expenditure for individuals at the worksite level
  • Pacific Northwest Prostate Cancer SPORE
    Public Health Sciences
  • Pacific Ovarian Cancer Research Consortium (SPORE in Ovarian Cancer)
    Public Health Sciences
  • Paddison Lab
    Human Biology, Public Health Sciences
    The Paddison Lab uses functional genetics to probe the underlying biology of mammalian stem/progenitor cells. We identify and characterize gene products affecting stem cell self-renewal, differentiation, proliferation, or survival through the use of RNAi knockdown technologies.
  • Partnership for the Advancement of Cancer Research Project
    Public Health Sciences
    The National Cancer Institute (NCI) has awarded funds to enhance and expand an existing collaboration between New Mexico State University (NMSU) and the Fred Hutchinson Cancer Research Center (FHCRC). This collaboration is designed to enhance the opportunities of minorities and underrepresented individuals, including Hispanics and Native Americans, to become trained and experienced in cancer research.
  • Pepe Lab
    Public Health Sciences
    The Pepe Lab develops guidelines and software to promote the use of sound statistical methods by scientists who are working to evaluate diagnostic or prognostic medical devices and biomarkers.
  • Peter Nelson Lab
    Human Biology, Public Health Sciences
    Dr. Peter Nelson's lab focuses on understanding the molecular, cellular and physiological events that lead to cancer initiation and progression. A particular emphasis involves hormonal carcinogenesis and prostate cancer with the goal of developing new strategies for diagnosis, prognosis and therapy.
  • Peters Studies
    Public Health Sciences
    Peter's Lab research is focused on the genetic and molecular epidemiology of common complex diseases, including cancer, obesity, type 2 diabetes, and cardiovascular diseases, as well as intermediate traits, including inflammation and metabolic measurements. Within well characterized and diverse study populations, we are studying the impact of common and rare genetic variants across the entire genome, as well as interactions between genetic variants and environmental factors (such as diet, exercise, smoking and aspirin use).
  • Physical Activity for Total Health (PATH)
    Public Health Sciences
    The goal of the study is to examine how moderate exercise may lower breast cancer risk
  • Population Architecture using Genomics and Epidemiology (PAGE)
    Public Health Sciences
  • Porter Lab
    Human Biology, Public Health Sciences
    The Porter Lab focuses on identifying and understanding the molecular events in normal and cancer cells that are associated with the initiation and progression of human cancer, with a focus on breast and ano-genital cancers. They also investigate the molecular profiles that distinguish different types of cancer or determine an individual's cancer risk.
  • Program in Prostate Cancer Research
    Public Health Sciences
    The Program in Prostate Cancer Research at Fred Hutchinson Cancer Research Center is a multidisciplinary program. The aim is to foster interactive communication and the development of new or expanded research projects between investigators with diverse expertise and interest in prostate cancer.
  • PROGRESS Study
    Public Health Sciences
  • Prospective Study of Selenium, Genetics of Selenoenzymes and Colorectal Cancer
    Public Health Sciences
  • Prostate Cancer Active Lifestyle Study (PALS)
    Public Health Sciences
    The PALS Study is enrolling for a study for prostate cancer patients who have chosen Active Surveillance of their cancer. The goal is to learn whether weight loss, through diet and exercise, will improve the health of men with low-grade prostate cancer.
  • Protein Biomarkers of Cancer Risk in Older Persons
    Public Health Sciences
    Using a case-cohort study design, this study evaluates if baseline plasma proteomic patterns can be used to distinguish between subjects who will and will not develop breast, colorectal, lung, and prostate cancers.
  • Quality Improvement and Infrastructure Development for Data Analytics (Choosing Wisely)
    Public Health Sciences
  • Quilt Study
    Public Health Sciences
    The Quilt Study is a study of predictors of disease progression and recurrence in women diagnosed with breast cancer at ages 45-79 to identify pre- and post-diagnosis exposures and events that may increase the risk of recurrence; assess pre-diagnosis exposures for their association with tumor characteristics and risk of recurrence; and evaluate how tumor markers, both ones currently used in clinical care and novel ones not currently in use, relate to breast cancer progression or recurrence across age groups.
  • Quit2Heal Study
    Public Health Sciences
  • Randolph Lab
    Public Health Sciences
    The Randolph Program's research focuses on mathematical and statistical methods for high-dimensional, functional and otherwise "non-standard" data including: image-based data, mass spectrometry, various spectroscopies, microbiome and genetic arrays as well as longitudinal data. Projects and collaborations involve studies for discovery and validation of molecular properties and markers of disease.
  • Random Digit Dialing Methodology for the 21st Century
    Public Health Sciences
  • REACH Study
    Public Health Sciences
    The purpose of the REACH Study is to further our understanding of why some young women develop breast cancer and others do not. Studies like the REACH Study compare information from people who have a particular disease to those who do not.
  • Reid Lab
    Human Biology, Public Health Sciences
    The Reid Lab is focused on understanding the mechanisms by which environmental exposures (i.e. aspirin or other nonsteroidal antiinflammatory agents) affect the evolution of clones that lead to the development of esophageal adenocarcinoma in patients with Barrett's esophagus.
  • Residential Proximity to Industrial Facilities and Risk of Non-Hodgkin Lymphoma
    Public Health Sciences
    We are investigating long-term environmental exposure to industrial pollutants as a risk factor for NHL.
  • Robins Lab
    Public Health Sciences
    Our research is computationally based and focuses on the adaptive immune system and its response to cancer and viral infection.
  • Role of Air Pollution in Rheumatoid Arthritis Incidence and Exacerbation
    Public Health Sciences
    This study is investigating ambient air pollution as a contributor to rheumatoid arthritis (RA) incidence and exacerbation, with a focus on exposure to particulate matter.
  • Role of Missense Changes in the BRCA1 and BRCA2 Breast Cancer Susceptibility Genes in Breast Cancer Among African-American Women: A Population-Based Approach
    Public Health Sciences
    The aims of this project are to conduct a series of statistical and laboratory analyses, using data and samples from a recently completed population-based study of breast cancer, to investigate the clinical significance of missense changes in BRCA1 and BRCA2 in African-American women.
  • Salama Lab
    Human Biology, Public Health Sciences
    The Salama lab studies the gastric bacterial pathogen Helicobacter pylori, which infects half the world's population and can cause ulcers and gastric cancer.
  • Seattle 5 a Day Worksite Program: Eat 5 for Life
    Public Health Sciences
    A randomized trial to evaluate the effectiveness of an intervention to maintain change in companies that have already received an intervention to increase fruit and vegetable consumption
  • Selenium, Genetic Variation in Selenoenzymes and Prostate Cancer
    Public Health Sciences
  • SHARE Study
    Public Health Sciences
    The focus of the SHARE Study is to determine risk factors specific to three different types of breast cancer. Studies like this one compare information from people who have a particular disease to those who do not. This type of research allows us to identify what specific characteristics of exposures may cause different types of breast cancer.
  • SPORE Supplement: Phase III Validation of a Consensus Panel of Ovarian Cancer Biomarkers Developed by SPORE/EDRN investigators
    Public Health Sciences
  • Statistical Methods for Medical Studies
    Public Health Sciences
  • Study of Reflux Disease and Its Complications
    Public Health Sciences
    The Study of Reflux Disease and its Complications was conducted by scientists at the Fred Hutch between the years of 1998 and 2002. The data from this study are still in use by scientists in investigating the causes and complications of reflux disease.
  • Sun Lab
    Public Health Sciences
    Statistical/computational methods and software packages for different types of omic data, including array or sequencing data for germline/somatic point mutations, copy number alterations, DNA methylation, and gene expression.
  • SWOG Statistics and Data Management Center
    Public Health Sciences
    The Southwest Oncology Group (SWOG) Statistics & Data Management Center is co-located at the Fred Hutchinson Cancer Research Center and Cancer Research And Biostatistics (CRAB) in Seattle, Washington.
  • TALK Study
    Public Health Sciences
  • Tamoxifen & Second Breast Cancer: Epidemiology and Pathology
    Public Health Sciences
    The purpose of this population-based nested case-control study is to evaluate how treatment with tamoxifen influences a breast cancer survivor's risk of developing a second, or contralateral, breast cancer.
  • Taniguchi Lab
    Human Biology, Public Health Sciences
    The Taniguchi Lab's long-term research objective is to elucidate molecular mechanism of DNA damage response pathways, such as the Fanconi Anemia-BRCA (FA-BRCA) pathway, and their involvement in carcinogenesis.
  • The Impact of Low-fat and Full-fat Dairy Consumption on Glucose homeostasis
    Public Health Sciences
  • The VIVA Trial
    Public Health Sciences
  • Thompson Studies
    Public Health Sciences
    Led by Dr. Beti Thompson, this research group works to understand why disparities in cancer incidence and survival rates exist among different populations, especially Latinos. The group also supports efforts to reduce other health disparities, including diabetes and pesticide exposure, in minority communities in the United States and abroad.
  • Training and Research in Colon Cancer Survival
    Public Health Sciences
  • Transdisciplinary Research on Energetics and Cancer (TREC)
    Public Health Sciences
  • Transdisciplinary Research on Energetics and Cancer (TREC)
    Public Health Sciences
  • Use of Exogenous Progestins and Risk of in situ and Invasive Breast Cancer
    Public Health Sciences
    The first project investigates the relationship between use of depo-medroxyprogesterone acetate on risk of in situ breast cancer among premenopausal women 20-44 years of age. The second study is a population-based case-control study evaluating the relationship between use of progestin containing hormone therapy regimens and risk of invasive pure lobular, ductal/lobular, and ductal carcinomas among postmenopausal women 55-74 years of age.
  • Vaughan Group
    Public Health Sciences
    Focus of research is the identification of environmental and host factors that underlie this dramatic increase in incidence. We have approached this through population-based case-control studies of cancer, community-based case-control studies of newly diagnosed Barrett’s, and a long-standing cohort study of persons with Barrett’s.
  • Vitamin D and Prostate Cancer: Biomarkers and Genetic Variation
    Public Health Sciences
  • Vitamin D, Diet and Activity Study
    Public Health Sciences
    The Vitamin D, Diet and Activity (ViDA) Study is being conducted to determine whether Vitamin D can help decrease breast cancer risk by reducing body fat or decreasing weight gain.
  • VITamins And Lifestyle (VITAL) Study: A Cohort Study of Dietary Supplements and Cancer Risk
    Public Health Sciences
  • Webquit Plus Study
    Public Health Sciences
  • WECARE Study: Interaction of Radiation, BRCA 1/2 and Breast Cancer
    Public Health Sciences
    A study to investigate gene-environment interactions influencing susceptibility in the etiology of breast cancer.
  • Women's Health Initiative
    Public Health Sciences
    The Women’s Health Initiative (WHI) is a major, long-term research program designed to address cardiovascular disease, cancer and osteoporosis – the most frequent causes of death, disability and poor quality of life in postmenopausal women. Fred Hutch is home to the study's coordinating hub, led by Dr. Garnet Anderson and colleagues Drs. Ross Prentice, Andrea LaCroix, and Charles Kooperberg
  • Women’s Health Initiative Clinical Coordinating Center Extension, 2011-2015
    Public Health Sciences
    A clinical trial testing the risks and benefits of different treatments in relation to the overall health of post-menopausal women
  • Wu Group
    Public Health Sciences
    The development and application of statistical methods for translational science and particularly for analysis of high-dimensional genomic data within the broader context of clinical trials as well as population-based genetic, gene-environment interaction, epigenetic, microbiome, and metabolomic studies.
  • Youth & Adult Smoking Research
    Public Health Sciences
    Youth and Adult Smoking Research works to learn more about attitudes and practices about smoking and non-smoking in teens. To learn how they change from their teen years to their young adult years. And to develop and test interventions for smoking prevention and smoking cessation, to see if they can help teens avoid and/or quit smoking.
  • Zhao Group
    Public Health Sciences
    Dr. Zhao's statistical work includes methodologies for personalized medicine, dynamic treatment regimes, survival analysis, and clinical trial design and analysis.
  • Zheng Lab
    Public Health Sciences
    Research interests are in the statistical methods for longitudinal data with time-to-event outcome, with a focus on using semi-parametric methods for estimating time-dependent ROC curves which are useful for evaluating the ability of longitudinal biomarkers or algorithms to identify cancer early, or signal disease prognosis.

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