Berger Lab Human Biology The goal of the Berger laboratory is to enable precision medicine by systematically uncovering the molecular alterations in cancer, determining the function of these variant alleles, and understanding how these alleles modulate response to targeted or immune-based therapies.
Beronja Lab Human Biology Regulation of epithelial growth in development and cancer. Tissue growth is a fundamental biological process that generates functional organs in development, and maintains them in the adulthood through continuous cycles of renewal and repair.
Bielas Lab Public Health Sciences, Human Biology The Bielas Lab studies the fundamental and clinical implications of nuclear and mitochondrial DNA mutations in the development of cancer and age-related disease. Translational research projects explore the potential utility of these mutations as novel DNA biomarkers for improved disease detection, treatment outcome, survival and quality of life.
Bolouri Lab Human Biology The Bolouri Lab is interested in understanding how gene regulatory interactions control cellular state and identity, particularly during development (e.g. in stem cells). The lab specializes in the development and use of computational systems biology methods to map gene regulatory networks.
Emerman Lab Human Biology, Basic Sciences The Emerman Lab studies the molecular and evolutionary basis for the replication of HIV and related viruses, with an emphasis on the interaction of these viruses with their host cells. Their goal is to understand what determines resistance or vulnerability to current, past and potential viral diseases.
Galloway Lab Human Biology, Public Health Sciences The Galloway Lab studies the mechanisms by which human papillomaviruses contribute to cancer, with an emphasis on types most likely to progress to cervical cancer. They work to understand the natural history of genital HPV infections and why only a small subset of women infected with high-risk HPVs develop cancer.
Geballe Lab Human Biology, Clinical Research The Geballe Lab studies the functions and mechanisms of genes encoded by large DNA viruses, such as cytomegalovirus and vaccinia virus, that act to promote viral growth by blocking host cell defenses.
Gujral Lab Human Biology Research is focused on the fundamental properties of cell regulation and signal pathways that drive cancer metastasis
Hockenbery Lab Human Biology, Clinical Research The Hockenbery lab studies programmed cell death (apoptosis) pathways that are defective in many cancer cells; and the role of cancer-cell metabolism in apoptosis, oncogene functions, and environmental/dietary risk factors, including excess supply of nutrients. After identifying cancer-selective targets, they carry out small-molecule screens for inhibitors to identify lead compounds as anticancer agents.
Holland Lab Human Biology The Holland lab works at the intersection of multiple disciplines to address the molecular basis of brain tumors and develop new approaches to their treatment. Our research focuses on developing mouse models of brain cancer that mimic the behavior of the disease in patients. Our work with mouse models has led to clinical trials in glioma patients. We also have developed imaging strategies to follow mouse brain tumors as they develop—a powerful system that is used to test promising new drugs with potential benefit for patients.
Hsieh Lab Human Biology The primary focus of the Hsieh lab is to unravel the post-transcriptional mechanisms that govern the genesis and progression of epithelial malignancies. Our research seeks to understand how rogue cells co-opt the critical interface between RNA and the protein synthesis machinery to drive specific cancer behavior at a molecular, cellular, and organismal level.
John Lee Lab Human Biology The John K. Lee lab at the Fred Hutch aims to identify molecular drivers and biological properties of prostate cancer that may be exploited for the development of new and effective treatments.
Kemp Lab Human Biology, Public Health Sciences The Kemp Lab seeks to identify the next generation of targeted anticancer agents. We use a combination of high throughput functional genomic and small molecule screens, and genomic analysis applied to a range of isogenic and patient derived tumor models. We are discovering and validating novel drug targets and therapeutic options for multiple solid tumor types including pancreatic, ovarian, head and neck and breast cancer.
Kugel Lab Human Biology The Kugel Lab primary research theme is to study how the dysregulation of chromatin modifying enzymes contributes to pancreatic cancer pathogenesis and, further, whether these pathways present liabilities that could be exploited for cancer therapy.
Laboratory for the Study of Metastatic Microenvironments Human Biology Dr. Ghajar directs the Laboratory for the Study of Metastatic Microenvironments (LSM2). The goal of his research program is to understand how microenvironments within distant tissues regulate dormancy and growth of disseminated tumor cells (DTCs), and whether these niches convey chemoresistance to dormant DTCs. His belief is that solving these puzzles will allow the development of therapeutic regimens that eradicate dormant DTCs before they can develop into full-blown metastases.
Lampe Lab Public Health Sciences, Human Biology The Paul Lampe Lab attempts to discover early detection cancer biomarkers and investigates the control of cell growth at the cell biology level. Of particular interest is the role that gap junctions play in the regulation of cell growth and the cell cycle, and the disruption of this relationship during cancer development.
MacPherson Lab Human Biology, Public Health Sciences The MacPherson Lab is focused on understanding the mechanisms through which cancer-mutated genes drive tumorigenesis. The lab studies small cell lung cancer and other solid tumors. We generate novel genetically engineered mouse models that we use to interrogate the biology underlying major cancer driver genes. We are particularly interested in understanding epigenetic regulators that are genetically mutated in human tumors.
Mpower Prostate Cancer Registry Human Biology, Public Health Sciences, Clinical Research Mpower prostate cancer registry is an online community for men who have been diagnosed with prostate cancer and their families and friends.
Overbaugh Lab Human Biology, Public Health Sciences The Overbaugh lab has a long-standing interest in understanding the mechanisms of HIV-1 transmission and pathogenesis. The lab is part of a larger team, comprising researchers in both Seattle and Kenya (The Nairobi HIV/STD Project). Trainees in the lab have opportunities to engage in studies of viral evolution, virus-host cell interactions, and viral immunology all within the context of international collaboration.
Paddison Lab Human Biology, Public Health Sciences The Paddison Lab uses functional genetics to probe the underlying biology of mammalian stem/progenitor cells. We identify and characterize gene products affecting stem cell self-renewal, differentiation, proliferation, or survival through the use of RNAi knockdown technologies.
Peter Nelson Lab Human Biology, Public Health Sciences Dr. Peter Nelson's lab focuses on understanding the molecular, cellular and physiological events that lead to cancer initiation and progression. A particular emphasis involves hormonal carcinogenesis and prostate cancer with the goal of developing new strategies for diagnosis, prognosis and therapy.
Porter Lab Human Biology, Public Health Sciences The Porter Lab focuses on identifying and understanding the molecular events in normal and cancer cells that are associated with the initiation and progression of human cancer, with a focus on breast and ano-genital cancers. They also investigate the molecular profiles that distinguish different types of cancer or determine an individual's cancer risk.
Reid Lab Human Biology, Public Health Sciences The Reid Lab is focused on understanding the mechanisms by which environmental exposures (i.e. aspirin or other nonsteroidal antiinflammatory agents) affect the evolution of clones that lead to the development of esophageal adenocarcinoma in patients with Barrett's esophagus.
Saha Lab Human Biology Conducts translational research focused on intrahepatic cholangiocarcinoma, a common form of liver cancer
Salama Lab Human Biology, Public Health Sciences The Salama lab studies the gastric bacterial pathogen Helicobacter pylori, which infects half the world's population and can cause ulcers and gastric cancer.
Taniguchi Lab Human Biology, Public Health Sciences The Taniguchi Lab's long-term research objective is to elucidate molecular mechanism of DNA damage response pathways, such as the Fanconi Anemia-BRCA (FA-BRCA) pathway, and their involvement in carcinogenesis.
Tapscott Lab Human Biology, Clinical Research The Tapscott Lab studies gene transcription and expression in normal development and disease, with an additional emphasis on rhabdomysarcomas (cancers with characteristics of skeletal muscle) and human muscular dystrophies. Other research areas include gene and cell therapies for muscular dystrophy, and the biology of triplet repeats and their associated diseases.
Vasioukhin Lab Human Biology The Vasioukhin lab studies the mechanisms and significance of cell polarity and cell adhesion in normal mammalian development and cancer. In addition, we have a significant interest in the mechanisms responsible for initiation and progression of human prostate cancer. We believe that it is important to study cells in their normal microenvironment.
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