Clinical Research Division, Fred Hutch
Dr. George Georges is a medical oncologist who treats patients with blood disorders like leukemia, lymphoma and myelodysplastic syndrome. His research seeks ways to reduce the toxicity of blood stem cell transplantation. Dr. Georges uses preclinical models to improve control of graft-vs.-host disease, in which a stem cell donor's immune cells (the graft) start to attack the recipient's organs. He also explores the use of blood stem cell transplantation to treat severe autoimmune diseases including systemic sclerosis, multiple sclerosis and aplastic anemia.
Hematopoietic cell transplantation for hematologic malignancies (leukemia, lymphoma and other malignancies) and autoimmune diseases (systemic sclerosis, multiple sclerosis and aplastic anemia).
Treatment of acute and chronic graft-versus-host disease.
Nonmyeloablative conditioning regimens for allogeneic hematopoietic cell transplantation.
Associate Professor of Medicine
University of Washington
Massachusetts Institute of Technology, 1986, B.S.
University of California, San Francisco, 1990, M.D.
Hematopoietic cell transplantation for severe autoimmune diseases: Autologous and allogeneic transplantation for diseases including systemic sclerosis, multiple sclerosis and aplastic anemia.
Nonmyeloablative hematopoietic cell transplantation: Regimens to reduce the toxicity of allogeneic transplantation, particularly in older patients or patients with medical comorbidities.
Hematopoietic stem cell and T cell gene therapy: Laboratory-based studies on hematopoietic stem cell expansion and genetic correction of underlying disease.
Development of radiation mitigators, for example, to reduce toxicity of gastrointestinal syndrome after irradiation.
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