Clinical Research Division, Fred Hutch
In her lab, clinical research and patient care, Dr. Pamela Becker strives to help patients with blood disorders. She has several main areas of research. First, she studies fundamental cancer biology, including how cancer develops and becomes resistant to treatment. Second, she is creating a new high-throughput test to help doctors choose the best treatment for each patient. This precision-medicine approach incorporates information about the tumor’s genomic profile and the results of a screen of more than 150 drugs and drug combinations on tumor tissue. Third, Dr. Becker works on gene therapy for Fanconi anemia. Finally, she leads clinical trials to test new drugs and other advances to help blood-cancer patients.
Professor of Medicine
University of Washington
Seattle Cancer Care Alliance
Harvard Medical School-Massachusetts Institute of Technology Health Sciences and Technology Program, 1986, M.D.
Harvard Graduate School of Arts and Sciences, 1986, Ph.D.
Dr. Becker is pursuing several areas of translational research investigation, including 1) the mechanism of adhesion mediated chemotherapy resistance in acute myeloid leukemia and 2) hematopoietic stem cell gene therapy for an inherited disorder of DNA repair, Fanconi anemia, 3) application of precision medicine to hematologic malignancies with incorporation of genomic analysis, gene expression analysis, and in vitro high throughput drug sensitivity data to optimize treatment.
Optimizing therapy of hematological malignancies
Gene therapy for inherited stem cell disorders
Study Number: 9757
Study Number: 9226
Study Number: 20180368
Study Number: UW18061
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