The Fred Hutch Biostatistics Program hosts seminars featuring presentations by Hutch and outside scientists to share their latest developments and recent research. Each seminar includes an hour-long presentation and discussion during which speakers showcase their work and findings.
This seminar will be held on Zoom due to the COVID-19 pandemic.
Biostatistics Seminar Series:
“Exploiting increased variability in DNA methylation for cancer biomarker discovery”
Abstract: Cancer development is almost ubiquitously associated with aberrant DNA methylation. Epigenetic instability or the loss of epigenetic control of important genomic domains can lead to increased methylation variability in cancer and cancer precursors, which may contribute to tumour heterogeneity. This phenomenon has been investigated for developing cancer early detection biomarkers (Phipson 2014, Teschendorff 2016). In this talk I will discuss statistical tests for differential variability and propose strategies to exploit increased methylation variability for improving cancer biomarker discovery. Joint tests of equal mean and variance will be compared to a partial AUC test. Genome-wide CpG methylation data for colorectal cancer and esophageal cancer were analyzed for illustration.