The Fred Hutch Biostatistics Program hosts seminars featuring presentations by Fred Hutch and outside scientists to share their latest developments and recent research. Each seminar includes an hour-long presentation and discussion during which speakers showcase their work and findings.
This seminar will be via Zoom.
I will discuss how to leverage large-scale EHR data linked with tumor mutation profiles to emulate cancer clinical trials in silico. This approach helps us to design real trials, making them more inclusive and efficient (Liu et al. Nature 2021). It also helps to identify a large number of predictive biomarkers, i.e. mutations that impact the survival of patients who are taking specific chemo, targeted or immunotherapies (Liu et al. Nature Medicine 2022). These mutation-drug interactions are critical for treatment planning and precision oncology. Finally, I will discuss how we can gain biological insights into treatment response by learning spatial cellular motifs that predict patient outcomes after immunotherapy.