The Fred Hutch Biostatistics Program hosts seminars featuring presentations by Hutch and outside scientists to share their latest developments and recent research. Each seminar includes an hour-long presentation and discussion during which speakers showcase their work and findings.
This seminar will be held on Zoom due to the COVID-19 pandemic.
Biostatistics Seminar Series:
“Revisiting Methodology for Optimizing Dose and Schedule of Immunotherapy Regimens”
There is a plethora of published methodology for adaptive Bayesian designs for Phase I trials in oncology when a single dose of an experimental agent is given to participants. However, in practice, cancer is not treated with a single administration, but instead through repeated administrations, of an agent, which we refer to as schedules or cycles. Thus, we seek to describe and contribute to methodology for designing studies in which several potential treatment schedules are being compared for potential dose-limiting toxicities (DLTs). This talk will review two existing designs in which the probability of DLT is generated through a cumulative hazard function applied to each participant's time-to-DLT, and also describe the strengths and limitations of those designs. We will then present an alternative approach, which we call Dose & Schedule Finding via Conditional Probabilities (DSCP), in which participants instead provide a series of longitudinal binary outcomes of DLT for each administration, and we model each outcome’s conditional probability of DLT on the previous outcome using traditional models from single-dose Bayesian adaptive designs. The operating characteristics of DSCP are examined by via simulations motivated by a clinical trial.