The Fred Hutch Biostatistics Program hosts seminars featuring presentations by Hutch and outside scientists to share their latest developments and recent research. Each seminar includes an hour-long presentation and discussion during which speakers showcase their work and findings.
This seminar will be held on Zoom due to the COVID-19 pandemic.
Biostatistics Seminar Series:
"Statistical tractography: an integral curve estimation for DTI/HARDI"
Diffusion tensor imaging (DTI) and High angular resolution diffusion imaging (HARDI) allow to study axonal fibers in a living brain. Despite being very popular, they produce datasets of imaging signals with notoriously high noise. The goal of tractography is to estimate the geometry of axonal fibers based on these datasets.
In this talk, we will look at a particular methodology called statistical tractography, that allows to trace the axonal fibers together with the surrounding confidence ellipsoids. We will discuss the different underlying models that connect the observed imaging signals and the axonal fibers, the asymptotical properties of the estimated fibers and of some test statistics. Extensions to longitudinal studies, growing numbers of gradient directions and some open problems will be discussed if time permits.