The Fred Hutch Biostatistics Program hosts seminars featuring presentations by Hutch and outside scientists to share their latest developments and recent research. Each seminar includes an hour-long presentation and discussion during which speakers showcase their work and findings.
This seminar will be held on Zoom due to the COVID-19 pandemic.
Biostatistic Seminar Series:
"HLA Class II Genes and Severe COVID-19"
Severe acute respiratory syndrome-coronavirus 2 (SARS-CoV-2) is highly infectious coronavirus and causes people to develop coronavirus disease 2019 (Covid-19). Since its initial outbreak in Wuhan, China, SARS-CoV-2 is now spreading to most countries in the world and is designated as a pandemic by World Health Organization. While most infected subjects suffer mild symptoms, approximately 20% of patients suffer severe infection. Little is known about host genetic susceptibility to severe infection. It has been postulated that host immunogenetic involve in two stages of immune responses: the initial immune response to recognize, present and eliminate infected cells, and, the secondary response, if the immune system is impaired, is to control damaged cells through releasing cytokines. Uncontrolled cytokine-inflammation, unfortunately, leads to excessive damages to tissues and organs, i.e., the severe Covid-19. In this presentation, we are exploring genetic associations of HLA class II genes with severe Covid-19.