"Sequence-based Linkage Analysis"
Linkage analysis is a powerful method for identifying disease genes. Recent dramatic improvements in sequencing render it a potential tool for marker acquisition and genotyping in linkage studies. However, the prospects of using this technology, as well as the possible limitations, have not been studied so far.
In this collaborative project we intend to explore the properties of sequence-based linkage analysis. We will study the variation among family members expected to be found by sequencing and compare it with empirical human data. We will then study the informativeness of a sequence-based marker map as a function of sequence-stretch length and spacing. Finally, we will apply the approach to dog pedigrees.