Graduate Students

Courses Offered at Fred Hutch

AUTUMN 2015

MCB 532  
Human Pathogenic Viruses (3 Credits)
Autumn 2015 (10/01/15-12/10/15)

Location: Fred Hutch Campus, Weintraub Bldg., Rm. B1-072/074
Meeting Time: Tues & Thurs, 1:30 - 3:00
Instructor: Michael Emerman (Fred Hutch/UW Microbiology Affiliate)

This course will cover the molecular biology and pathogenesis of major groups of human viruses, including retroviruses, flaviviruses, herpesviruses, influenza viruses, poliovirus, papillomaviruses, and others. Course registration is limited to 30.

For more information contact Michael Emerman, (206) 667-5058.

MCB 532 Course website

MCB 522
Developmental Basis of Human Disease
(3 Credits)
Autumn 2015  (10/01/15-12/10/15)

Location: Fred Hutch Campus, Weintraub Bldg., Rm. B1-076
Meeting Time:
Tues & Thurs, 1:30 - 3:00

Instructor: Cecilia Moens (Fred Hutch/UW Biology Affiliate)

This ten-week course will explore the intimate relationship between human genetic disease and developmental biology. Each week we will choose a different human disorder whose genetic basis has been recently discovered, and we will discuss how the same genes regulate key processes in animal development. The second meeting of each week will be an opportunity for students to present recent papers from the literature relating to these developmental processes. We will end each week by formulating hypotheses about how mutations in these developmental control genes may cause the human disease in which they have been implicated.

MCB 522 Course website

For more information, contact Cecilia Moens, (206) 667-5627

CONJ 537
Mechanisms of Transcriptional Regulation (1.5 Credits)
Autumn 2015 - Weeks 6-10 (11/05/15-12/10/15)

Location: Fred Hutch Campus, Weintraub Bldg., Rm. B1-072/074
Meeting Time: Tues & Thurs, 3:20 - 4:40
Organizer: Toshio Tsukiyama (Fred Hutch/UW Biochemistry Affiliate)

A five week graduate survey course concentrating on biochemical mechanisms of gene transcription. The course will cover broad range of transcriptional regulation including: Mechanisms of transcriptional initiation (Steve Hahn); Regulation of transcription by chromatin (Toshio Tsukiyama); Transcriptional regulation, development and diseases in mammals (Steve Tapscott).

For more information about the course contact Toshio Tsukiyama, (206) 667-4996

CONJ 537 Course website

WINTER 2016

CONJ 512 
How To Give A Scientific Seminar (1.5 Credits)
Winter 2016 — Weeks 1-5 (01/05/16-02/04/16)

Location: Fred Hutch Campus; Weintraub Bldg., Rm. B1-072
Meeting Time: Tues & Thurs, 1:30 - 3:00p
Organizers: Sue Biggins (Fred Hutch/UW Biochemistry Affiliate), Jihong Bai (Fred Hutch/UW Biochemistry Affiliate)

This course will provide training for MCB graduate students to effectively give a scientific seminar about their research. At the end of the class, students will have prepared and practiced a complete seminar and received feedback from their peers and the instructors.

For more information about the course contact Sue Biggins, (206) 667-1351

CONJ 512 Course description

CONJ 544 
Protein Structure, Modification and Regulation (1.5 Credits)
Winter 2016 — Weeks 1-5  (01/05/16-02/04/16)

Location:Fred Hutch Campus, Weintraub Bldg., Rm. B1-074/076
Meeting Time: Tues & Thurs, 3:20 - 4:40
Instructor: Roland Strong (Fred Hutch/UW Immunology Affiliate)
Readings: Selected papers from primary literature.

We will provide an overview of the general principles of protein structure, with a focus on modern methods used to determine and analyze protein structures. The goal of the course is to provide the non-specializing scientist the knowledge to critically read and understand protein structure papers from the primary literature, and to incorporate a structural molecular biology perspective into their own research.

Background and Prerequisites:  The course will assume a knowledge base equivalent to an advanced undergraduate biochemistry course, at the level of Stryer Biochemistry or Alberts Molecular Biology of the Cell.

Enrollment will be limited to 20 Students

For more information about the course contact Roland Strong, (206) 667-5587

CONJ 544 Course Description

CONJ 529 
Cell Migration (1.5 Credits)
Winter 2016 — Weeks 6-10 (02/09/16-03/10/16)

Location: Fred Hutch Campus; Weintraub Bldg., Rm. B1-074/076
Meeting Time: Tues & Thurs, 3:20 to 4:40
Instructors: Cecilia Moens (FHCRC/UW Biology & BMSD Affiliate), Jon Cooper (FHCRC/UW Biochemistry Affiliate)

This course will explore mechanisms of cell migration in vivo and in cell culture. We will discuss the cell biology of different forms of cell migration, the extracellular cues that direct migration and how these cues are integrated by the migrating cell.

For more information about the course contact Cecilia Moens, (206) 667-5627

CONJ 529 Course website

MCB 515 
MCB Literature Review (2 non-graded Credits)
Winter 2015 (01/06/16-03/16/16)

Location: Fred Hutch Campus, Weintraub Bldg., Rm. B1-074/076
Meeting Time: Wednesdays, 4:00-5:20
Instructors: Katie Peichel (Fred Hutch/UW Biology Affiliate), Rich Gardner (UW Pharmacology Department)

For more information contact Katie Peichel, (206) 667-1628

MCB 515 Course Website

SPRING 2016

MCB 539 
Biological Basis of Neoplasia (3 Credits)
Spring 2016

Location: Fred Hutch Campus, Weintraub Bldg., Rm. B1-072/074
Meeting Time: Tues & Thurs, 3:20 to 4:40
Instructors: Valeri Vasioukhin (Fred Hutch/UW Pathology Affiliate), Toshiyasu Taniguchi, (Fred Hutch/UW Pathology Affiliate)

This course allows students to gain experience in applying the several disciplines which comprise cellular and molecular biology toward a deeper understanding of a complex biological problem: neoplastic change. The course consists of a series of lectures and discussion meetings to introduce students to the major themes in research in the cellular and molecular biology of neoplastic change. They cover principal molecular mechanisms responsible for tumor initiation and progression, with a specific emphasis on DNA repair mechanisms, cell cycle checkpoints and loss of normal tissue homeostasis. The latest state of the art research in  Cancer Biology will be presented by invited scientists experts in their relevant field.  The discussion meetings will concentrate on selected major papers in cancer biology and be presented and discussed by the students with help and guidance of the instructors.  

Student overall participation, activity during discussions, quality and depth of the research paper presentation, and the written research proposal on one of the topics in cancer biology will be used for course credit and grading.

Prerequisites: Introductory biochemistry and cell biology.

For more information contact: Toshiyasu Taniguchi  (206) 667-4996 or Valeri Vasioukhin, (206) 667-1710

MCB 539 Course website

MCB 516 
MCB Literature Review (2 non-graded Credits)
Spring 2016

Location: Fred Hutch Campus, Weintraub Bldg., Rm. B1-074/076
Meeting Time: Wednesdays, 4:00-5:20
Instructors: Katie Peichel (Fred Hutch/UW Biology Affiliate), Rich Gardner (UW Pharmacology Department)

For more information contact Katie Peichel, (206) 667-1628

MCB 516 Course Website

AUTUMN 2016

CONJ 533  
The Dynamic Chromosome (1.5 Credits)
Autumn 2016 — Weeks 1-5 

Location: Fred Hutch Campus, Weintraub Bldg., Rm. B1-072/074
Meeting Time: Tues & Thurs, 3:20 to 4:40
Organizer: Sue Biggins (Fred Hutch/UW Biochemistry Affiliate)

This course is a graduate level introduction to the chromosome, viewing it as the ultimate organelle. Topics this year will focus on the functions and evolution of chromosomal elements as well as the mechanisms that ensure the maintenance and propagation of chromosomes. The class will use a combination of lecture, literature review, and in class discussion to explore genetic, biochemical, and cytological methods for defining our current knowledge about chromosomes. The course requires students to have taken undergraduate cell biology, biochemistry and genetics. Active participation in discussion is required.

For more information about the course contact Sue Biggins, (206) 667-1351

CONJ 533 Course website

CONJ 537
Mechanisms of Transcriptional Regulation (1.5 Credits)
Autumn 2016 - Weeks 6-10  

Location: Fred Hutch Campus, Weintraub Bldg., Rm. B1-072/074
Meeting Time: Tues & Thurs, 3:20 to 4:40
Organizer: Toshio Tsukiyama (Fred Hutch/UW Biochemistry Affiliate)

A five week graduate survey course concentrating on biochemical mechanisms of gene transcription. The course will cover broad range of transcriptional regulation including: Mechanisms of transcriptional initiation (Steve Hahn); Regulation of transcription by chromatin (Toshio Tsukiyama); Transcriptional regulation, development and diseases in mammals (Steve Tapscott).

For more information about the course contact Toshio Tsukiyama, (206) 667-4996

CONJ 537 Course website

WINTER 2017

CONJ 544 
Protein Structure, Modification and Regulation (1.5 Credits)
Winter 2015 — Weeks 1-5  

Location: FHCRC Day Campus, Weintraub Bldg., Rm. B1-074/076
Meeting Time: Tues & Thurs, 3:20 to 4:40
Instructors: Barry Stoddard (Fred Hutch/UW Biochemistry Affiliate)
Readings: Selected papers from primary literature.

We will provide an overview of general principles of protein structure and function, including (i) forces and interactions that contribute to folding, dynamics and stability, (ii) the diversification of protein fold and function during evolution; (iii) the functional implications of progression from single domain to multi-domain structures; (iii) modular repeat proteins; and (iv) principles of protein-ligand binding.  A key goal of the class is to introduce students to the best practice and use of common protein visualization and analysis tools, including the Protein Structural Database, PyMol, fold-prediction servers and homology modeling servers and algorithms.

Background and Prerequisites: The course will assume knowledge at the level of an advanced undergraduate biochemistry course.  Knowledge in the areas we will discuss at the level of Stryer Biochemistry or Alberts Molecular Biology of the Cell  will be assumed.

For More Information and Course Overview

MCB 515 
MCB Literature Review (2 non-graded Credits)
Winter 2017  

Location: Fred Hutch Campus, Weintraub Bldg., Rm. B1-074/076
Meeting Time: Wednesdays, 4:00-5:20
Instructors: Katie Peichel (Fred Hutch/UW Biology Affiliate), Rich Gardner (UW Pharmacology Department)

For more information contact Katie Peichel, (206) 667-1628

MCB 515 Course Website

SPRING 2017

MCB 533 
Evolutionary Genetics and Genomics (3 Credits)
Spring 2017  

Location: Fred Hutch Campus, Weintraub Bldg., Rm. B1-072/074
Meeting Time: Tues & Thurs, 1:30 - 3:00
Instructors: Katie Peichel (Fred Hutch/UW Biology Affiliate), Harmit Malik, (Fred Hutch/UW Genome Sciences Affiliate)

An understanding of evolutionary processes is becoming increasingly important in biomedical research. The purpose of this elective is to introduce graduate students with backgrounds in molecular, cellular, and developmental biology to evolutionary approaches. A combination of lectures, discussions of primary literature, and "hands-on" assignments to provide training in comparative and genomic approaches will be used during the course. Course registration is limited to 15.

For more information contact Katie Peichel, (206) 667-1628

MCB 533 Course website

MCB 516 
MCB Literature Review (2 non-graded Credits)
Spring 2017

Location: Fred Hutch Campus, Weintraub Bldg., Rm. B1-074/076
Meeting Time: Wednesdays, 4:00-5:20
Instructors: Katie Peichel (Fred Hutch/UW Biology Affiliate), Rich Gardner (UW Pharmacology Department)

For more information contact Katie Peichel, (206) 667-1628

MCB 516 Course Website