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Dose Escalation Study of Anti-CD38 Monoclonal Antibody in Patients With Selected CD38+ Hematological Malignancies

Complete title: A Phase 1 Dose Escalation Safety and Pharmacokinetic Study of Multiple Intravenous Administrations of a Humanized Monoclonal antibody (SAR650984) Against CD38 in Patients with Selected CD38+ Hematological Malignancies

Research Study Number       2724.00
Principal Investigator       Bill Bensinger, MD
Phase       I

Look up trial at NIH

Research Study Description

Primary Objective:

- To determine the maximum tolerated dose (MTD)/maximum administered dose (MAD) of SAR650984

Secondary Objectives:

- To characterize the global safety profile including cumulative toxicities

- To evaluate the pharmacokinetic (PK) profile of SAR650984 in the proposed dosing schedule(s)

- To assess the pharmacodynamics, immune response, and preliminary disease response

Eligibility Criteria (must meet the following to participate in this study)

** For Eligibility information, please click on the "Look up trial at NIH" link above. **

Other eligibility criteria may apply.

Research Study Number       2724.00
Contact       Seattle Cancer Care Alliance Intake Office
Telephone       800-804-8824 / 206-288-1024

Hematologic Malignancies

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