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Complete title: A Phase I, Open-label, Multicentre Study to Assess the Safety, Tolerability, Pharmacokinetics and Preliminary Anti-tumour Activity of Ascending Doses of AZD8186 in Patients with Advanced Castration-resistant Prostate Cancer (CRPC), Squamous Non-Small Cell Lung Cancer (sqNSCLC), Triple Negative Breast Cancer (TNBC) and Patients with Known PTEN-deficient/mutated or PIK3CB Mutated Advance Solid Malignancies, with Expansion to Assess the Pharmacodynamic Activity of AZD8186
|Research Study Number||20131275|
|Principal Investigator||Tia Higano, MD|
Research Study Description
There are two parts to this study: Part A, dose escalation, and Part B, expansion cohort(s) at the intended therapeutic dose(s).
Eligibility Criteria (must meet the following to participate in this study)
Other eligibility criteria may apply.
Breast Cancer; Genitourinary Cancer; Lung Cancer; Prostate Cancer; Solid Tumors
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