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Clinical Trial Detail

Feasibility and Outcomes of Allogeneic HCT Compared to Chemotherapy in Older AML Patients

Complete title: Feasibility and Outcomes of Allogeneic Hematopoietic Cell Transplantation (HCT) Compared to Conventional Therapy for Older and Medically Infirm Patients Diagnosed with Acute Myeloid Leukemia or High-Risk Myelodysplastic Syndromes: A Prospective Observational Study

Research Study Number 2368.00
Principal Investigator Mohamed Sorror, MD, MSc
Phase NA

Research Study Description

The purpose of this study is to compare treatment methods and outcomes of patients diagnosed with acute myeloid leukemia (AML) and myelodysplastic syndrome (MDS).

Eligibility Criteria (must meet the following to participate in this study)

Ages Eligible for Study: 18 Years to 80 Years

Genders Eligible for Study: Both

Sampling Method: Non-Probability Sample

Study Population:

The study population will include non-M3 AML and high-risk MDS patients considered for induction chemotherapy at FHCRC and the Seattle Cancer Care Alliance Network and five other Core institutions (Stanford School of Medicine, Cleveland Clinic, Northwestern University, Massachusetts General Hospital, and University of Utah) in addition to an unidentified number of affiliate sites. We anticipate enrollment of a total sample of 1000 patients.

- Patients with new diagnoses of non-M3 AML or high-risk MDS who present for AML-like treatment that could plausibly produce a complete remission (CR); for example intensive induction chemotherapy, low dose single agent chemotherapy, hypo-methylation agent, or a similar therapy

- Explicitly intend to establish follow-up care at one of the collaborating institutions.

- Patients of =18 years of age and are being treated by the adult AML service.

- Able to read and speak English.

- Willing and able to provide informed consent.

Other eligibility criteria may apply.

Exclusions (conditions that would prevent participation in this study)

- Patients of =17 years of age or who are =18 and receive treatment under the pediatric AML service.

- Patients older than 80 years

- Patients with <6 months projected survival due to active second malignancy or other medical problem

Other exclusion criteria may apply.

Research Study Number 2368.00
Contact Seattle Cancer Care Alliance Intake Office
Telephone 800-804-8824 / 206-606-1024

Keywords: Leukemia, Acute Myeloid (AML); Hematologic Malignancies; Leukemia; Myelodysplastic Syndromes (MDS)

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