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Clinical Trial Detail

Sapanisertib or Pazopanib Hydrochloride in Treating Patients With Locally Advanced or Metastatic Sarcoma

Complete title: A Phase I/ Randomized Phase II Study of MLN0128 Vs. Pazopanib in Patients with Locally Advanced/Unresectable and/or Metastatic Sarcoma

Research Study Number A091304
Principal Investigator Lee Cranmer
Phase I/II

Research Study Description

This partially randomized phase I/II trial studies the side effects and best dose of sapanisertib and to see how well it works compared to pazopanib hydrochloride in treating patients with sarcoma that is too large to be removed (locally advanced) or has spread to other areas of the body (metastatic). Sapanisertib and pazopanib hydrochloride both work to stop the growth of tumor cells by blocking enzymes that are needed for cell growth. It is not yet known whether sapanisertib may be more effective than standard treatment with pazopanib hydrochloride in treating patients with locally advanced or metastatic sarcoma.

Eligibility Criteria (must meet the following to participate in this study)

** For Eligibility information, please click on the "Look up trial at NIH" link above. **

Other eligibility criteria may apply.

Research Study Number A091304
Contact Seattle Cancer Care Alliance Intake Office
Telephone 800-804-8824 / 206-606-1024

Keywords: Sarcoma; Solid Tumors; Neoplasms, Germ Cell and Embryonal; Neuroendocrine Tumor; Neoplasms; Sarcoma, Synovial; Neuroectodermal Tumors; Neoplasms, Nerve Tissue; Neoplasms, Connective and Soft Tissue; Neoplasms, Muscle Tissue; Neoplasms, Fibrous Tissue; Neurofibroma; Neurofibrosarcoma; Nerve Sheath Neoplasms; Leiomyosarcoma; Histiocytoma; Histiocytoma, Malignant Fibrous; Neurilemmoma; Nervous System Diseases; Peripheral Nervous System Diseases; Neuroma; Fibrosarcoma

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