Clinical Trial Detail

Clinical Trials

Clinical Trial Detail

Basket Study of Entrectinib (RXDX-101) for the Treatment of Patients With Solid Tumors Harboring NTRK1/2/3, ROS1, or ALK Gene Rearrangements (Fusions) (STARTRK-2)

Complete title: An Open-Label, Multicenter, Global Phase II Basket Study of Entrectinib for the Treatment of Patients with Locally Advanced or Metastatic Solid Tumors that Harbor NTRK1/2/3, ROS1, or ALK Gene Rearrangements

Research Study Number 20152369
Principal Investigator Gabriela Chiorean
Phase II

Research Study Description

This is an open-label, multicenter, global Phase 2 basket study of entrectinib (RXDX-101) for the treatment of patients with solid tumors that harbor an NTRK1/2/3, ROS1, or ALK gene rearrangement. Patients will be assigned to different baskets according to tumor type and gene rearrangement. NSCLC and mCRC will be the main patient populations of interest

Eligibility Criteria (must meet the following to participate in this study)

** For Eligibility information, please click on the "Look up trial at NIH" link above. **

Other eligibility criteria may apply.

Research Study Number 20152369
Contact Seattle Cancer Care Alliance Intake Office
Telephone 800-804-8824 / 206-606-1024

Keywords: Bladder Cancer; Brain Cancer; Breast Cancer; Central Nervous System (CNS); Colon Cancer; Esophageal Cancer; Gastrointestinal Cancer; Gynecological Cancer; Head and Neck Cancer; Hematologic Malignancies; Kidney Cancer; Liver Cancer; Lung Cancer; Lymphoma; Melanoma; Mesothelioma; Ovarian Cancer; Pancreatic Cancer; Prostate Cancer; Renal Cancer; Salivary Gland Cancer; Sarcoma; Solid Tumors; Thyroid Cancer; Neuroendocrine Tumor; Lung Carcinoma, Non-Small-Cell (NSCLC); Carcinoma, Bronchogenic; Digestive System Neoplasms; Lymphoma, Large-Cell, Anaplastic; Adenocarcinoma; Colorectal Neoplasms; Carcinoma; Endocrine Gland Neoplasms; Apudoma; Carcinoid Tumor; Cholangiocarcinoma; Adenoma; Adnexal Diseases; Neoplasms, Bronchial; Esophageal Diseases

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