Clinical Trial Detail

Clinical Trials

Clinical Trial Detail

Prevention of Bone Loss After Pediatric Hematopoietic Cell Transplantation

Complete title: Prevention of Bone Loss after Pediatric Hematopoietic Cell Transplantation

Research Study Number 9223
Principal Investigator K.Scott Baker
Phase II

Research Study Description

This is a Phase 2, open-label, randomized, controlled clinical study of pediatric subjects treated with pamidronate with calcium and vitamin D versus calcium and vitamin D alone following hematopoetic cell transplantation (HCT). The purpose of this study is to test the hypothesis that subjects receiving pamidronate with calcium and vitamin D will have higher lumbar spine bone mineral content (LBMC) measured by dual-energy X-ray tomography (DXA) at 1 year post-HCT than subjects receiving calcium and vitamin D alone (Control Group). Sixty subjects (=1 and <18 years of age at the time of enrollment and receiving an allogeneic HCT for a hematologic malignancy or severe aplastic anemia) will be evaluated at the University of Minnesota Amplatz Children's Hospital and Seattle Children's Hospital. Subjects randomized to pamidronate treatment will receive infusions approximately 100, 180, and 270 days after HCT. Laboratory evaluations, DXA, and peripheral quantitative computed tomography (pQCT) will be performed at specified time points to evaluate safety and treatment efficacy. Subjects will participate in the study for 1 year.

Eligibility Criteria (must meet the following to participate in this study)

** For Eligibility information, please click on the "Look up trial at NIH" link above. **

Other eligibility criteria may apply.

Research Study Number 9223
Contact Seattle Cancer Care Alliance Intake Office
Telephone 800-804-8824 / 206-606-1024

Keywords: Hematologic Malignancies; Hematopoietic Cell Transplantation (HCT); Osteoporosis; Osteopenia

Disclaimer: We update this information regularly. However, what you read today may not be completely up to date.

Please remember:

  • Talk to your health care providers first before making decisions about your health care.
  • Whether you are eligible for a research study depends on many things. There are specific requirements to be in research studies. These requirements are different for each study.

Subscribe to an RSS feed of all trials