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Clinical Trial Detail

Study of MOR209/ES414 in Metastatic Castration-Resistant Prostate Cancer

Complete title: A Phase I Study of ES414 In Patients with Metastatic Castration-Resistant Prostate Cancer

Research Study Number 20142613
Principal Investigator Tia Higano, MD
Phase I

Research Study Description

The study will be conducted in 2 Stages. The primary objective of Stage 1 of the study is to identify the maximum tolerated dose (MTD) of MOR209/ES414 administered intravenously to patients with mCRPC. Secondary objectives are to evaluate the tolerability, pharmacokinetics (PK), pharmacodynamics (PD), immunogenicity, cytokine response, and clinical activity of MOR209/ES414.

The primary objective of Stage 2 of the study is to evaluate the clinical activity of MOR209/ES414 in patients that have or have not received prior chemotherapy. Secondary objectives are to further characterize the safety profile, PK, PD, and immunogenicity of MOR209/ES414.

Eligibility Criteria (must meet the following to participate in this study)

** For Eligibility information, please click on the "Look up trial at NIH" link above. **

Other eligibility criteria may apply.

Research Study Number 20142613
Contact Seattle Cancer Care Alliance Intake Office
Telephone 800-804-8824 / 206-606-1024

Keywords: Genitourinary Cancer; Prostate Cancer; Solid Tumors

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