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Clinical Trial Detail

JAK Inhibitor Before Donor Stem Cell Transplant in Treating Patients With Primary or Secondary Myelofibrosis

Complete title: JAK-2 Inhibitor Prior to Allogeneic Stem Cell Transplant for Patients with Primary and Secondary Myelofibrosis: A Prospective Study

Research Study Number 9033
Principal Investigator Rachel Salit
Phase II

Research Study Description

This phase II trial studies how well giving a JAK inhibitor before a donor stem cell transplant works in treating patients with myelofibrosis that developed without another condition (primary) or evolved from other bone marrow disorders (secondary). JAK inhibitors are a class of drugs that may stop the growth of abnormal cells by blocking an enzyme needed for cell growth. Giving a JAK inhibitor before a donor stem cell transplant may help reduce symptoms of myelofibrosis such as inflammation and enlargement of the spleen, improve the patient's general physical condition, and prevent complications from occurring after the transplant. Infusing healthy stem cells from a donor into the patient may help the patient's bone marrow work normally and make stem cells, red blood cells, white blood cells, and platelets. Giving a JAK inhibitor before a donor stem cell transplant may help improve transplant outcomes in patients with myelofibrosis.

Eligibility Criteria (must meet the following to participate in this study)

Ages Eligible for Study: 18 Years and older (Adult, Senior)

Genders Eligible for Study: Both


- PART 1: Disease criteria

-- * Diagnosis of primary MF (PMF) as defined by the 2008 World Health Organization classification system or diagnosis of secondary MF as defined by the International Working Group (IWG) for Myeloproliferative Neoplasms Research and Treatment criteria

-- * Patients meeting the criteria for intermediate-1, intermediate-2 or high-risk disease by the Dynamic International Prognostic Scoring System (DIPSS) or DIPSS-plus scoring system

- PART 1: Ability to understand and the willingness to sign a written informed consent document


- PART 2: Meeting criteria for 1st phase as above, at time of initiation of JAK inhibitor, including ability to understand and willingness to sign a written informed consent; patients arriving to our institution for transplant and not enrolled in Part 1 may still be enrolled in Part 2 if Part 1 criteria met; these patients will have Part 1 endpoints transcribed from medical records

- PART 2: Received JAK inhibitor for at least 8 weeks immediately prior to conditioning and be able to continue until Day -4 pre-transplant

- PART 2: Performance status score

-- * Karnofsky >= 70

- PART 2: Calculated creatinine clearance using the Cockcroft-Gault formula or 24 hr urine creatinine clearance must be > 60 ml/min

- PART 2: Total serum bilirubin must be < 3 mg/dL unless the elevation is thought to be due to Gilbert's disease or hemolysis

- PART 2: Transaminases must be < 3 x the upper limit of normal

- PART 2: Patients with clinical or laboratory evidence of liver disease will be evaluated for the cause of liver disease, its clinical severity in terms of liver function, and the degree of portal hypertension; patients with fulminant liver failure, cirrhosis with evidence of portal hypertension or bridging fibrosis, alcoholic hepatitis, hepatic encephalopathy, or correctable hepatic synthetic dysfunction evidenced by prolongation of the prothrombin time, ascites related to portal hypertension, bacterial or fungal abscess, biliary obstruction, chronic viral hepatitis with total serum bilirubin > 3 mg/dL, and symptomatic biliary disease will be excluded

- PART 2: Diffusing capacity of the lung for carbon monoxide (DLCO) corrected > 60% normal

-- * May not be on supplemental oxygen

- PART 2: Left ventricular ejection fraction > 40% OR

- PART 2: Shortening fraction > 26%

- PART 2: Comorbidity Index < 5 at the time of pre-transplant evaluation


- DONOR: Human leukocyte antigen (HLA)-matched or 1 antigen mismatched sibling donor

- DONOR: 10 of 10 HLA-matched or 1 allele mismatched (9 of 10) unrelated donor

- DONOR: Peripheral blood is preferred over bone marrow for non-umbilical cord blood recipients

- DONOR: Umbilical cord blood units will be selected according to the following umbilical cord blood graft selection criteria; one or 2 cord blood (CB) units may be used to achieve the required cell dose

- DONOR: The CB graft(s) must be matched at 4-6 HLA-A, B, DR Beta 1 (DRB1) loci with the recipient and therefore may include 0-2 mismatches at the A or B or DRB1 loci; unit selection will be based on cryopreserved nucleated cell dose and intermediate resolution A, B antigen and DRB1 allele typing for determination of HLA-match; while HLA-C antigen/allele level typing is not considered in the matching criteria, if available, it may be used to optimize unit selection

- DONOR: Selection of two CB units is allowed to provide sufficient cell dose (see below for algorithm to determine single versus double unit transplant); when multiple units are selected, the following rules apply:

-- * The CB unit with the least HLA disparity (with the patient) will be selected first (i.e., selection priority is 6/6 match > 5/6 match > 4/6 match); additional CB units then may be selected to achieve the required cell dose, as outlined below; if a second unit is required, this unit will be the unit that most closely HLA matches the patient and meets minimum size criteria outlined below of at least 1.5 x 10^7 total nucleated cells (TNC)/kg (i.e. a smaller, more closely matched unit will be selected over a larger, less well matched unit as long as minimum criteria are met)

-- * If two CB units are used:

--- ** The total cell dose of the combined units must be at least 3.0 x 10^7 TNC per kilogram recipient weight

--- ** Each CB unit MUST contain at least 1.5 x 10^7 TNC per kilogram recipient weight

-- * Algorithm for determining single versus double unit cord blood transplant:

--- ** Match grade 6/6: TNC dose >= 2.5 x 10^7/kg

--- ** Match grade 5/6, 4/6: TNC dose >= 4.0 (+/- 0.5) x 10^7/kg

- DONOR: General comments:

-- * Units will be selected first based on the TNC dose and HLA matching

-- * Cluster of differentiation (CD)34+ cell dose will not be used for unit selection unless 2 units of equal HLA-match grade and similar TNC dose (+/- 0.5 x 10^7 TNC/kg) are available; in this case, the unit with the larger CD34+ cell dose (if data available) should be selected

-- * A CB unit that is 5/6 mismatched but homozygous at the locus of mismatch should be chosen over a 5/6 unit with bidirectional mismatch even if the latter unit is larger (has more cells); this also applies to 4/6 units; this is only applicable to choosing units within a given match grade

-- * Other factors to be considered:

--- ** Within the same HLA match grade, matching at DR takes preference

--- ** Cord blood banks located in the United States are preferred

-- * Up to 5% of the cord blood product(s), when ready for infusion, may be withheld for research purposes as long as thresholds for infused TNC dose are met; these products will be used to conduct studies involving the kinetics of engraftment and immunobiology of double cord transplantation

Other eligibility criteria may apply.

Exclusions (conditions that would prevent participation in this study)


- PART 1: Evidence of human immunodeficiency virus (HIV) infection or known HIV positive serology

- PART 1: Uncontrolled viral, bacterial, or fungal infections at the time of study enrollment

- PART 1: History of prior allogeneic transplant

- PART 1: Pregnant or breastfeeding


- PART 2: Uncontrolled viral or bacterial infection at the time of study enrollment

- PART 2: Active or recent (prior 6 month) invasive fungal infection without infectious disease (ID) consult and approval

- PART 2: History of HIV infection

- PART 2: Pregnant or breastfeeding

- PART 2: Patients without an HLA-identical or 1-allele-mismatched related donor or unrelated donor or umbilical cord blood units that meet transplant criteria

Other exclusion criteria may apply.

Research Study Number 9033
Contact Seattle Cancer Care Alliance Intake Office
Telephone 800-804-8824 / 206-606-1024

Keywords: Hematologic Malignancies; Myelodysplastic Syndromes (MDS); Neoplasms; Myeloproliferative Disorders (MPD); Myelofibrosis, Primary; Myelofibrosis, Secondary; Bone Marrow Diseases

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  • Talk to your health care providers first before making decisions about your health care.
  • Whether you are eligible for a research study depends on many things. There are specific requirements to be in research studies. These requirements are different for each study.

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