Research

A Growing Research Portfolio

Our global oncology research focuses on the biology, epidemiology, diagnosis and treatment of high-burden cancers in low- and middle-income countries. Our portfolio is expanding from infection-related cancers to include other globally relevant cancers, including breast cancer, which is a leading cancer in women. Fred Hutch is also home to a global breast cancer initiative that develops context-appropriate guidelines for breast cancer control, screening, diagnosis and treatment in low- and middle-income countries. In one of our newest clinical trials in Uganda, we will provide lymphoma drugs through subcutaneous injection, rather than the typical intravenous delivery, to patients in low-resource settings. In 2018, we launched a pilot award program to encourage Fred Hutch faculty to develop novel approaches to improve cancer diagnosis in low-and middle-income countries.

Below are a few of our key active research studies.

Defining the Molecular Profile of Breast Cancer in Uganda and its Clinical Implications (Uganda)

+

Investigators:

Jackson Orem, MBChB, MMed, PhD
Manoj Menon, MD, MPH
Solomon Kibudde, MBChB, MMed
Nixon Niyonzima, MBChB, MSC, PhD

Launched in 2018 with $1.4 million in funding from GlaxoSmithKline through the African NCD Open Lab Programme, this study is characterizing the molecular portrait and subtype prevalence of women presenting with an initial diagnosis of early stage, locally advanced or metastatic breast cancer; evaluating the potential use of widely available molecular technology to improve the diagnosis of breast cancer in resource-limited settings; and determining the feasibility of an all-oral chemotherapy regimen for the treatment of locally advanced breast cancer.

Study sites:
UCI-Fred Hutch Cancer Centre
Uganda Cancer Institute

Human Herpesvirus-8 Replication and Kaposi Sarcoma Response to Treatment

+

Investigators:

Warren Phipps, MD, MPH
Edus H. Warren, MD, PhD
Jackson Orem, MBChB, MMed, PhD

This study is defining the relationship between human herpesvirus-8 replication and Kaposi sarcoma treatment outcomes and evaluating the potential of HHV-8 to serve as a prognostic biomarker in people with Kaposi sarcoma.

Study sites:
Uganda Cancer Institute
UCI-Fred Hutch Cancer Centre

HIV Integration-Mediated Modulation of Immune Regulation in HPV-Associated Cancers (Uganda)

+

This study of women with HIV who are found to have precancerous lesions during routine cervical cancer screening is comparing those whose precancers spontaneously resolve with those who develop cancer. The investigators aim to determine whether a novel mechanism may be partly responsible for the high incidence of HPV-associated cancers in people with HIV infection.

Study sites:
UCI-Fred Hutch Cancer Centre
Seattle Children’s Research Institute
Fred Hutch
University of Manitoba