Clinical Research Job Openings

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39 Found open positions

Administrative Manager II

FH Clinical Research Division
Category: Administrative Support
Seattle, WA, US
Job ID: 13373

Overview

Cures Start Here. At Fred Hutchinson Cancer Research Center, home to three Nobel laureates, interdisciplinary teams of world-renowned scientists seek new and innovative ways to prevent, diagnose and treat cancer, HIV/AIDS and other life-threatening diseases. Fred Hutch’s pioneering work in bone marrow transplantation led to the development of immunotherapy, which harnesses the power of the immune system to treat cancer. An independent, nonprofit research institute based in Seattle, Fred Hutch houses the nation’s first cancer prevention research program, as well as the clinical coordinating center of the Women’s Health Initiative and the international headquarters of the HIV Vaccine Trials Network. Careers Start Here.

 

This position will be responsible for managing academic faculty and scientific staff appointments and promotions, and related faculty affairs for the Clinical Research Division (CRD), Fred Hutchinson Cancer Research Center. In conjunction with CRD and Fred Hutch Leadership, coordinate external faculty searches, appointment processes for faculty, and assist with faculty reviews. This position will also steward faculty promotions, including scientific staff appointments and promotions, in cooperation with related faculty affairs staff in the UW Division of Medical Oncology, for those concurrent appointments and promotion processes for all CRD faculty with joint appointments. This position will report to the Practice Plan Administrator and work in close collaboration with the Division Director, Associate Division Director and Senior Operations Director.

Responsibilities

  • Implement faculty guidelines, rules, policies, and procedures consistent with Fred Hutch policies and in collaboration with other Fred Hutch departments and partners.
  • Plan annual, midterm, and 5-year faculty reviews according to review calendar and timelines in partnership with CRD Directors Office Administrative Manager. Provide direction to faculty for preparation of required materials.
  • Administer faculty promotions. Advise and support promotion committees; manage review process from initiation to final approval; provide direction to candidate on required materials; serve as liaison to other division(s) and the University of Washington, where applicable.
  • Support CRD A&P Committee. Work with leadership to develop monthly agenda, document meetings, follow up on action items, process scientific staff appointments.
  • Support faculty recruitment process. Advise and support search committees; serve as liaison with University of Washington, interact with HR on advertisement placements logistics; manage applicant materials; plan candidate visits as applicable; monitor recruitment committee activities and follow up on needed actions.
  • Coordinate faculty development and mentoring programs as directed.
  • Ensure that faculty CVs are current in relation to Research Administration guidelines
  • Perform other duties as assigned.

Qualifications

Required:

  • Bachelor’s degree or equivalent and at least 5 years of relevant experience
  • Strong competency in Microsoft Office

Preferred:

  • Experience working in an academic, clinical, or scientific environment preferred

Professional Attributes:

  • Strong interpersonal, customer service and communication skills
  • Ability to navigate complex organizations and systems
  • Maintain a high level of confidentiality, sound judgment, and fine attention to detail
  • Manage and rank multiple tasks within a fast-paced environment while operating under strict time constraints
  • Impeccable record keeping, filing and organizational skills
  • Ability to manage relationships effectively and build collaborative bridges
  • Ability to learn and follow policies and procedures
  • Ability to draft clear written instructions and business memos
  • Highly developed project coordination skills
  • Must be able to work independently and be self-motivated
  • Motivated by challenge to solve problems and positively affect systems and people

Our Commitment to Diversity

We are committed to cultivating a workplace in which diverse perspectives and experiences are welcomed and respected. We are proud to be an Equal Opportunity and VEVRAA Employer. We do not discriminate on the basis of race, color, religion, creed, ancestry, national origin, sex, age, disability, marital or veteran status, sexual orientation, gender identity, political ideology, or membership in any other legally protected class. We are an Affirmative Action employer. We encourage individuals with diverse backgrounds to apply and desire priority referrals of protected veterans. If due to a disability you need assistance/and or a reasonable accommodation during the application or recruiting process, please send a request to our Employee Services Center at escmail@fredhutch.org or by calling 206-667-4700.

Advanced Practice Provider - Pediatric BMT

FH Clinical Research Division
Category: Advanced Practice Providers
Seattle, WA, US
Job ID: 12180

Overview

Cures Start Here. At Fred Hutchinson Cancer Research Center, home to three Nobel laureates, interdisciplinary teams of world-renowned scientists seek new and innovative ways to prevent, diagnose and treat cancer, HIV/AIDS and other life-threatening diseases. Fred Hutch’s pioneering work in bone marrow transplantation led to the development of immunotherapy, which harnesses the power of the immune system to treat cancer. An independent, nonprofit research institute based in Seattle, Fred Hutch houses the nation’s first cancer prevention research program, as well as the clinical coordinating center of the Women’s Health Initiative and the international headquarters of the HIV Vaccine Trials Network. Careers Start Here.

 

We offer great generous benefits, including relocation and tuition reimbursement.

Responsibilities

The pediatric advanced practice provider (APP) provides care for pediatric blood and marrow transplant patients in both inpatient and outpatient setting under the supervision of the attending physician.  The APP is responsible for the primary care of the patient to include assessment, triage and management of the transplant patient as part of a collaborative transplant team.  Responsibilities include obtain medical history, perform physical examinations, review and order diagnostic studies, radiographs and prescribe treatments.  APPs provide follow-up care of bone marrow donors under the supervision of attending physician.  PALS certification is required for this position within 3 months of hiring date.

Qualifications

  • Must be a graduate of a Physician Assistant  or Nurse Practitioner program (appropriate for care of Pediatric patients)
  • 2 years of experience in a Pediatric Transplant and/or Oncology setting is required – prefer inpatient experience.
  • Eligible for licensure in the State of Washington
  • Have National Certification as appropriate for profession
  • DEA licensure required
  • Strong verbal and written communication skills required. 
  • Cerner/EPIC computer skills preferred; CPOE experience required
  • Strong team player with a can-do attitude is a must!  Ability to work as part of a multi-disciplinary team is essential.
  • Must enjoy long-term relationships with patients undergoing intense therapy. 

 

Please include a cover letter when applying for this job that includes your specific interest in the Advanced Practice Provider position and working for Fred Hutchinson Cancer Research Center (either as an additional attachment on your profile or merged into the file that contains your resume). 

Our Commitment to Diversity

We are committed to cultivating a workplace in which diverse perspectives and experiences are welcomed and respected. We are proud to be an Equal Opportunity and VEVRAA Employer. We do not discriminate on the basis of race, color, religion, creed, ancestry, national origin, sex, age, disability, marital or veteran status, sexual orientation, gender identity, political ideology, or membership in any other legally protected class. We are an Affirmative Action employer. We encourage individuals with diverse backgrounds to apply and desire priority referrals of protected veterans. If due to a disability you need assistance/and or a reasonable accommodation during the application or recruiting process, please send a request to our Employee Services Center at escmail@fredhutch.org or by calling 206-667-4700.

Advanced Practice Provider: Pediatric BMT

FH Clinical Research Division
Category: Advanced Practice Providers
Seattle, WA, US
Job ID: 13599

Overview

Cures Start Here. At Fred Hutchinson Cancer Research Center, home to three Nobel laureates, interdisciplinary teams of world-renowned scientists seek new and innovative ways to prevent, diagnose and treat cancer, HIV/AIDS and other life-threatening diseases. Fred Hutch’s pioneering work in bone marrow transplantation led to the development of immunotherapy, which harnesses the power of the immune system to treat cancer. An independent, nonprofit research institute based in Seattle, Fred Hutch houses the nation’s first cancer prevention research program, as well as the clinical coordinating center of the Women’s Health Initiative and the international headquarters of the HIV Vaccine Trials Network. Careers Start Here.

 

We offer great generous benefits, including relocation and tuition reimbursement.

Responsibilities

The pediatric advanced practice provider (APP) provides care for pediatric blood and marrow transplant patients in both inpatient and outpatient setting under the supervision of the attending physician. The APP is responsible for the primary care of the patient to include assessment, triage and management of the transplant patient as part of a collaborative transplant team. Responsibilities include obtain medical history, perform physical examinations, review and order diagnostic studies, radiographs and prescribe treatments. APPs provide follow-up care of bone marrow donors under the supervision of attending physician. PALS certification is required for this position within 3 months of hiring date.

 

Please include a cover letter when applying for this job that includes your specific interest in the Advanced Practice Provider position and working for Fred Hutch (either as an additional attachment on your profile or merged into the file that contains your resume)

Qualifications

  • Must be a graduate of a Physician Assistant or Nurse Practitioner program (appropriate for care of Pediatric patients)
  • Eligible for licensure in the State of Washington
  • Have National Certification as appropriate for profession
  • DEA licensure required
  • Strong oral and written communication skills required
  • EMR based computer skills and experience with CPOE preferred
  • Strong team player with a can-do attitude is a must! Ability to work as part of a multi-disciplinary team is essential
  • Must enjoy long-term relationships with patients undergoing intense therapy
  • Pediatrics, Oncology or BMT experience preferred

Our Commitment to Diversity

We are committed to cultivating a workplace in which diverse perspectives and experiences are welcomed and respected. We are proud to be an Equal Opportunity and VEVRAA Employer. We do not discriminate on the basis of race, color, religion, creed, ancestry, national origin, sex, age, disability, marital or veteran status, sexual orientation, gender identity, political ideology, or membership in any other legally protected class. We are an Affirmative Action employer. We encourage individuals with diverse backgrounds to apply and desire priority referrals of protected veterans. If due to a disability you need assistance/and or a reasonable accommodation during the application or recruiting process, please send a request to our Employee Services Center at escmail@fredhutch.org or by calling 206-667-4700.

Advanced Practice Provider: Survivorship

FH Clinical Research Division
Category: Advanced Practice Providers
Seattle, WA, US
Job ID: 13612

Overview

Cures Start Here. At Fred Hutchinson Cancer Research Center, home to three Nobel laureates, interdisciplinary teams of world-renowned scientists seek new and innovative ways to prevent, diagnose and treat cancer, HIV/AIDS and other life-threatening diseases. Fred Hutch’s pioneering work in bone marrow transplantation led to the development of immunotherapy, which harnesses the power of the immune system to treat cancer. An independent, nonprofit research institute based in Seattle, Fred Hutch houses the nation’s first cancer prevention research program, as well as the clinical coordinating center of the Women’s Health Initiative and the international headquarters of the HIV Vaccine Trials Network. Careers Start Here.

 

We offer great generous benefits, including relocation and tuition reimbursement.



The clinical component of the Survivorship Program at the Fred Hutchinson Cancer Research Center (Fred Hutch) provides comprehensive clinical evaluations for cancer survivors through the Seattle Cancer Care Alliance (SCCA) Survivorship Clinic. The overall mission of the Survivorship Program is to advance the science of the field of survivorship in order to improve the lives of survivors, empowering them through education and advocacy, and disseminating knowledge regarding the unique needs of survivors to health care providers and the community.


Cancer and its treatment can result in some potentially long-lasting or late-onset effects. The Survivorship Clinic addresses various problems cancer survivors may face after therapy ends. These include pain, fatigue, fear of recurrence, living with uncertainty, neuropathy, lymphedema, bone loss, sexual dysfunction, cardiovascular disease, memory issues, and future cancer risk. As part of the Survivorship Clinic, patients are given a thorough medical screening and health evaluation to assess late complications from treatment and to develop a plan to support their future health. During their appointment, survivors are provided with a cancer Treatment Summary and Survivorship Care Plan that summarizes all of the cancer treatment they received, outlines possible late and long term effects they may experience as a result of their treamtment, and includes both screening recommendations and instruction in healthy behaviors to aid in maintaining the overall long-term health of the survivor. The Survivorship Clinic staff communicates the information contained in the Survivorship Care Plan with any other healthcare providers involved in the survivor’s care. The Survivorship Clinic also evaluates current concerns and issues related to the survivor’s cancer history and which often includes connecting or referring them to specialists or resources in their community. The overall goal is to help survivors optimize their health in the years following their cancer treatment.


The Survivorship Clinic Nurse Practitioner/Physician Assistant will be responsible for provision of clinical care and patient education for adult survivors of pediatric cancers or for survivors diagnosed in adulthood. They will work with a comprehensive team including the program director and co-director, the program nurse coordinator, and the program manager toward the goal of extending survivorship services to all oncology patients, regardless of age, place or type of treatment. S/he will collaborate with other providers within the Survivorship Clinic, within other SCCA oncology discipline clinics, and also with physicians and other health care professionals to define best practices of care, develop comprehensive survivorship care guidelines, and establish referral networks internal and external to the SCCA.


The Survivorship Clinic Nurse Practitioner/Physician Assistant will report to the program director and to the SCCA nurse practitioner/physician assistant supervisor(s) and will work independently in performing daily responsibilities, as appropriate for scope of practice. The Survivorship Clinic Nurse Practitioner/Physician Assistant will work with the program director, co-director and the program manager on other duties as assigned related to overall Survivorship Program growth and development as appropriate.

Responsibilities

Comprehensive onsite evaluations for cancer survivors including:

  • Review of diagnosis, treatment, acute and chronic complications and co-morbidities
  • Risk-adapted history and physical examination, laboratory and diagnostic studies
  • Psychosocial and functional needs assessment
  • Referral to appropriate subspecialties and services
  • Preparation of treatment summary or review of treatment summary developed by survivorship RN, including guidelines and recommendations for follow-up
  • Patient education
  • Provide written (and oral when necessary) communication of survivors evaluation back to referring provider and/or primary care provider


Other Duties as assigned by program director or program manager:

  • Participate in program outreach activities (e.g. local or regional presentations regarding survivorship, or the survivorship program survivor education conferences, and other related activities), including off-hours as necessary
  • Participate in program development activities (e.g. visits to internal or off-site clinics or hospitals, and other related activities, development of standard of care guidelines)
  • Develop educational materials for survivors (e.g. Survivor notebook, health links, etc.)
  • Create, review and maintain accuracy and completeness of survivorship database care plan recommendations

 

Professional Conduct

Employees within the Survivorship Program are expected to maintain high standards of professionalism in their interactions with patients, referring providers and other team members. Professional conduct includes:

  • Fosters positive and professional interpersonal relationships with patients, families, staff, referring physicians and other visitors.
  • Actively promotes positive working relationships within survivorship team and all SCCA, Fred Hutch and UW Medical Center staff to create an affirming work environment.
  • Is flexible and positive in accepting other duties or projects as assigned by the program director or program manager.
  • Identifies and reports barriers to clinical and departmental effectiveness and facilitates/ suggests effective problem solving.
  • Seeks positive resolution of interpersonal conflicts though self-awareness, mutual respect and skillful communication.
  • Is aware of and follows policy and procedures regarding infection control, health, safety and security.
  • Adheres to survivorship team and Fred Hutch, SCCA and departmental personnel policies including attendance, punctuality, and timekeeping standards.
  • Supports Fred Hutch and the SCCA in its efforts to fulfill its mission.

Qualifications

  • Accreditation and current license as an ARNP, PA or PA-C in the state of Washington
  • Minimum of two years of nurse practitioner or physician assistant experience
  • Experience working in a clinic or research setting preferred
  • Strong oral and written communication skills
  • Basic computer skills
  • Must be able to work as part of a multi-disciplinary team
  • Oncology and/or BMT experience preferred
  • Must be available to work some evening hours

Our Commitment to Diversity

We are committed to cultivating a workplace in which diverse perspectives and experiences are welcomed and respected. We are proud to be an Equal Opportunity and VEVRAA Employer. We do not discriminate on the basis of race, color, religion, creed, ancestry, national origin, sex, age, disability, marital or veteran status, sexual orientation, gender identity, political ideology, or membership in any other legally protected class. We are an Affirmative Action employer. We encourage individuals with diverse backgrounds to apply and desire priority referrals of protected veterans. If due to a disability you need assistance/and or a reasonable accommodation during the application or recruiting process, please send a request to our Employee Services Center at escmail@fredhutch.org or by calling 206-667-4700.

Assistant or Associate Professor, Oncology (Hematopoietic Cell Transplant Program)

Clinical Research Division
Category: Faculty: Associate, Assistant, and Full Member
Seattle, WA, US
Job ID: 62512

Hematopoietic Cell Transplant Program

The Fred Hutchinson Cancer Research Center (Fred Hutch) and the University of Washington (UW) Department of Medicine are jointly recruiting a full-time faculty member at the Assistant Member/Assistant Professor or Associate Member/Associate Professor level without tenure due to funding (WOT), commensurate with experience, in the Clinical Research Division of the Fred Hutch and the Division of Medical Oncology, Department of Medicine at the UW. This position has an annual service period of 12 months [July 1-June 30].  The Fred Hutch, home of three Nobel laureates, is an independent, nonprofit research institution dedicated to the development and advancement of biomedical research to eliminate cancer and other potentially fatal diseases. Recognized internationally for its pioneering work in bone-marrow transplantation and immunotherapy, Fred Hutch and the UW provide a unique environment for conducting translational research and clinical care. The Fred Hutch, in collaboration with its clinical and research partners, the University of Washington and Seattle Children’s, is a National Cancer Institute-designated comprehensive cancer center.

The primary appointment will be in the Clinical Research Division of Fred Hutch. The selected individual for the advertised position is expected to enhance our clinical care and clinical research programs in hematopoietic cell transplantation and immunotherapy. All clinical research interests will be considered however, there is a particular interest in applicants with demonstrated experience in the field of immunotherapy. Applicants with extensive research experience will also be considered. University of Washington faculty engage in teaching, research and service.

Anticipated start date August 1, 2019

Assistant/Associate Member Faculty Position Pathology Specialist

Clinical Research Division
Category: Faculty: Associate, Assistant, and Full Member
Seattle, WA, US
Job ID: 64469

The Fred Hutchinson Cancer Research Center (Fred Hutch) and the University of Washington (UW) invite exceptional candidates to apply for a full-time faculty appointment at the rank of Assistant Member/Assistant Professor or Associate Member/Associate Professor level, commensurate with experience, in the Clinician-Scholar pathway in the Clinical Research Division of the Fred Hutch and in the Department of Pathology at UW without tenure due to funding (WOT). Fred Hutch, home of three Nobel laureates, is an independent, nonprofit research institution dedicated to the development and advancement of biomedical research to eliminate cancer and other potentially fatal diseases. Recognized internationally for its pioneering work in bone-marrow transplantation and immunotherapy, Fred Hutch provides a unique environment for conducting translational research and clinical care. Fred Hutch, in collaboration with its clinical and research partners, the University of Washington, Seattle Childrens Hospital, and Seattle Cancer Care Alliance (SCCA) is a National Cancer Institute-designated comprehensive cancer center.

The selected individual is expected to enhance our clinical care and clinical research programs in anatomic pathology, with particular focus in hematopoietic cell transplantation and immunotherapy.  Based on qualifications, this position could entail a leadership role. We offer access to a highly collaborative and diverse research environment, modern laboratory space and state-of-the-art core facilities.  Research is a core priority at the Hutch and successful candidates will be expected to maintain an active clinical research interest, as demonstrated by peer reviewed publications.  The primary appointment will be in the Clinical Research Division of Fred Hutch with secondary appointment with the Department of Pathology at the University of Washington.

Assistant/Associate Member, Pediatric Hematology/Oncology

Clinical Research Division
Category: Faculty: Associate, Assistant, and Full Member
Seattle, WA, US
Job ID: 51944

The Fred Hutchinson Cancer Research Center (Fred Hutch) and the University of Washington (UW) are jointly recruiting a full-time laboratory-based faculty member at the Assistant/Associate Member, and Assistant/Associate Professor level WOT (without tenure due to funding), on the Physician/Scientist pathway in the Clinical Research Division of Fred Hutch and the Division of Pediatric Hematology/Oncology, Department of Pediatrics at the UW. The Fred Hutchinson Cancer Research Center, home of three Nobel laureates, is an independent, nonprofit research institution dedicated to the development and advancement of biomedical research to eliminate cancer and other potentially fatal diseases. Recognized internationally for its pioneering work in bone marrow transplantation and immunotherapy, Fred Hutch and the UW provide a unique environment for conducting translational research and clinical care. Fred Hutch in collaboration with its clinical and research partners, the University of Washington and Seattle Children's, is a National Cancer Institute-designated comprehensive cancer center.

 

The goal is to recruit a prominent scientist/thought leader and translational researcher in the field of pediatric malignancy, with solid malignancies a priority. The successful candidate has an MD, MD/PhD, or PhD, ad is expected to engage in active laboratory and clinical research related to the molecular pathogenesis, genomics/epigenomics, intracellular signaling pathways, or targeted translational therapeutics of neoplasms common in children. Physician faculty member would also participate in the care of patients with pediatric malignancies either in oncology or stem cell transplant service. Candidates must demonstrate a track-record of high-quality peer-reviewed publications, as well as independent research funding or competitive funding potential.

 

The primary appointment will be in the Clinical Research Division of Fred Hutch. Applicants must have an MD, MD/PhD, or PhD degree (or foreign equivalent) and US Board certification in Pediatric Hematology/Oncology (for physician candidates). Physician candidates, in order to be eligible for sponsorship for an H-1B visa, graduates of foreign (non-U.S.) medical schools must show successful completion of all three steps of the U.S. Medical Licensing Exam (USMLE), or equivalent as determined by the Secretary of Health and Human Services. Fred Hutch and University of Washington faculty engage in teaching, research and service.

 

Interested candidates should submit a curriculum vitae, and a letter summarizing research goals and career plans to Dr. Soheil Meshinchi at smeshinc@fredhutch.org.

 

The Fred Hutchinson Cancer Research Center and the University of Washington are affirmative action, equal opportunity employers. Both institutions are dedicated to building culturally diverse faculties and strongly encourage applications from women, minorities, individuals with disabilities and protected veterans.

Associate/Full Member Faculty Member, Breast and Ovarian Cancer

Clinical Research Division
Category: Faculty: Associate, Assistant, and Full Member
Seattle, WA, US
Job ID: 61948

The Fred Hutchinson Cancer Research Center invites applications from scientists working in the area of breast cancer research to lead a translational research program. Applicants will be considered at the rank of Associate or Full Faculty member, and we are seeking individuals who share our goals to advance an understanding of the biological basis of breast cancer, and to translate findings to the clinic.

We will consider PhD, MD/PhD, or MD scientists working in areas that include, but are not limited to: steroid receptors, signaling pathways, microenvironment, metastasis, systems biology, computational biology, and the biology of therapeutic response/resistance, genetics/genomics. A track record of relevant publication and funding commensurate with appointment level is highly desirable. Physician-scientists in any relevant medical discipline are encouraged to apply.

The successful candidate will enter a vibrant and dynamic research environment with opportunities to collaborate with basic and clinical researchers across diverse disciplines. The Breast and Ovary Cancer Program is one of 8 designated research programs in the Fred Hutch/University of Washington Cancer Consortium.

Opportunities exist for joint and/or affiliate appointment in the Fred Hutch Divisions of Human Biology, Clinical Research, Basic Sciences, Public Health Sciences, or Vaccine and Infectious Disease, as well as the University of Washington, depending on mutual interests. Applicants will also be eligible for membership in the Fred Hutch-based Seattle Translational Tumor Research (STTR) program, a multidisciplinary consortium of more than 500 faculty from Fred Hutch, the University of Washington, and Seattle Children’s, who work collaboratively on all aspects of solid tumor basic, translational, and clinical research.

Additional information about Fred Hutch and the Scientific Divisions can be found at:

http://www.fhcrc.org/science/

Bioinformatics Analyst I/II

FH Clinical Research Division
Category: Biostatistics, Bioinformatics and Computational Biology
Seattle, WA, US
Job ID: 13731

Overview

Cures Start Here. At Fred Hutchinson Cancer Research Center, home to three Nobel laureates, interdisciplinary teams of world-renowned scientists seek new and innovative ways to prevent, diagnose and treat cancer, HIV/AIDS and other life-threatening diseases. Fred Hutch’s pioneering work in bone marrow transplantation led to the development of immunotherapy, which harnesses the power of the immune system to treat cancer. An independent, nonprofit research institute based in Seattle, Fred Hutch houses the nation’s first cancer prevention research program, as well as the clinical coordinating center of the Women’s Health Initiative and the international headquarters of the HIV Vaccine Trials Network. Careers Start Here.

Responsibilities

A Bioinformatics Analyst I/II position is available immediately to join the laboratory of Dr. Edus H. Warren in the Clinical Research Division of Fred Hutch. The bioinformatics analyst will join several ongoing National Institutes of Health-funded projects focused on the immunobiology, immunogenetics, and genomics of cancers and infections common in sub-Saharan Africa. These projects are anticipated to involve analysis of high-dimensional molecular data generated from both tissues and single cells and obtained from subjects enrolled on various studies at the Hutchinson Centre Research Institute in Kampala, Uganda.

Qualifications

Suitable applicants should have a Ph.D. degree in bioinformatics, data science, or a closely-related field. Extensive experience with analysis of whole genome, whole exome, and targeted sequence data is required. Applicants with a Master’s degree in bioinformatics or related field with considerable post-degree experience in the field will also be considered.


The successful candidate will be a scientifically driven, well-organized self-starter with a track record of effective communication of previous work in both oral and written format. They will also be an individual committed to team science who thrives in a collaborative, team-oriented environment.

Our Commitment to Diversity

We are committed to cultivating a workplace in which diverse perspectives and experiences are welcomed and respected. We are proud to be an Equal Opportunity and VEVRAA Employer. We do not discriminate on the basis of race, color, religion, creed, ancestry, national origin, sex, age, disability, marital or veteran status, sexual orientation, gender identity, political ideology, or membership in any other legally protected class. We are an Affirmative Action employer. We encourage individuals with diverse backgrounds to apply and desire priority referrals of protected veterans. If due to a disability you need assistance/and or a reasonable accommodation during the application or recruiting process, please send a request to our Employee Services Center at escmail@fredhutch.org or by calling 206-667-4700.

Clinical Research Coordinator I/II

FH Clinical Research Division
Category: Administrative Support
Seattle, WA, US
Job ID: 13936

Overview

Cures Start Here. At Fred Hutchinson Cancer Research Center, home to three Nobel laureates, interdisciplinary teams of world-renowned scientists seek new and innovative ways to prevent, diagnose and treat cancer, HIV/AIDS and other life-threatening diseases. Fred Hutch’s pioneering work in bone marrow transplantation led to the development of immunotherapy, which harnesses the power of the immune system to treat cancer. An independent, nonprofit research institute based in Seattle, Fred Hutch houses the nation’s first cancer prevention research program, as well as the clinical coordinating center of the Women’s Health Initiative and the international headquarters of the HIV Vaccine Trials Network. Careers Start Here.


This individual will work under the supervision of the Principal Investigator(s) and will be required to perform their esponsibilities with a high level of independence within the scope of study protocol(s) and institutional guidelines. The ability to work across Fred Hutchinson, University of Washington and Seattle Cancer Care Alliance will be critical.


The ideal candidate will be able to address the full set of responsibilities in this listing and commit to a 1.0 FTE position, 0.5 FTE will also be considered depending on the applicant's depth of experience.

Responsibilities

  • Principal Investigator Support:
    • Serve as designee of the Principal Investigator (PI) to manage the daily clinical operations of assigned research studies in accordance with regulatory, GCP guidelines and institutional policy
    • Liase with SCCA clinical and administrative teams to identify appropriate and effective recruitment pathways
  • Recruitment and Enrollment
    • Review study candidates’ medical records for study eligibility
    • Ensure informed consent, initiate patient enrollment, and ensure accurate enrollment records are maintained
  • Education
    • Educate clinical teams, co-investigators, ancillary departments, and patients to ensure safe and accurate protocol implementation
  • Protocol Implementation
    • Because the nature of the clinical study may vary within this job, the CRC must be capable of moving seamlessly between different protocols
    • Develop and maintain tools for study implementation, which may include data collection tools, study reference materials, and study specific orders. Revise and utilize tools as necessary to fulfill the aims of the clinical trial.
    • Initiate scheduling of patient clinic visits, and on-going study visits. Ensure clinical procedures, lab test, and other protocol specific activities are completed as outlined in the protocols.
    • Complete requisition forms, assemble kits for upcoming research visits, transport laboratory samples, and ensure samples are processed and shipped according to study specific guidelines, while tracking and maintaining research supplies.
  • Budget & Billing
    • Understand clinical trial budget and billing plans for patients enrolled on clinical trials or studies
    • Work with internal partners to obtain and submit budget and billing information
  • Other Duties Which May Be Required
    • Assist the Principal Investigator (PI) with protocol development, revision, and study analysis
    • Collaborate with Investigational Drug Services (IDS) on drug assignment, dispensation information, and maintain regular communication regarding status of study subjects
    • Ensure study drug self-administration and accountability with patients
    • Perform non-clinical ECGs
    • Administer study questionnaires and disperse study-related payments
    • Conduct study interviews and participate in focus groups
    • Function as a protocol liaison with clinical teams, patients, and when necessary, other institutions or drug companies
    • Maintain or assist in maintaining IRB correspondence and regulatory documentation.  Prepare or assist in preparing consent forms, continuation review reports, protocol submissions and modifications, and other study reports
    • Maintain appropriate source documentation, and complete or assist with accurate data entry into case report forms in a timely manner
    • Coordinate monitoring visits and respond to queries and other requests from study monitors
    • Identify and report adverse events in accordance with protocol, regulatory guidelines, and institutional policy
    • Participate in the review of charges for patients on clinical trials to ensure billing compliance
    • Travel for industry sponsored investigator meetings
    • Maintain knowledge in the field through attending related project meetings, reading related literature, and maintaining professional associations
    • Other duties as assigned

Qualifications

  • Associate degree required, with Bachelor’s degree preferred
  • Applicant must have a minimum of one to two years of clinical research or related experience.
  • This position requires excellent organizational skills, attention to detail, ability to problem solve and to prioritize multiple competing tasks in a dynamic environment
  • Collaborative focus is essential, as well as strong written and verbal communication skills, including computer skills
  • Previous experience in oncology research and clinical data collection is preferred
  • Previous experience in investigator-initiated and industry-sponsored drug studies is preferred
  • Previous experience in biobehavioral intervention studies (e.g. web apps, acupuncture) is preferred
  • Previous experience in survey research and qualitative interviewing is preferred

Our Commitment to Diversity

We are committed to cultivating a workplace in which diverse perspectives and experiences are welcomed and respected. We are proud to be an Equal Opportunity and VEVRAA Employer. We do not discriminate on the basis of race, color, religion, creed, ancestry, national origin, sex, age, disability, marital or veteran status, sexual orientation, gender identity, political ideology, or membership in any other legally protected class. We are an Affirmative Action employer. We encourage individuals with diverse backgrounds to apply and desire priority referrals of protected veterans. If due to a disability you need assistance/and or a reasonable accommodation during the application or recruiting process, please send a request to our Employee Services Center at escmail@fredhutch.org or by calling 206-667-4700.

Clinical Research Nurse

FH Clinical Research Division
Category: Nursing and Nursing Support
Seattle, WA, US
Job ID: 13339

Overview

Cures Start Here. At Fred Hutchinson Cancer Research Center, home to three Nobel laureates, interdisciplinary teams of world-renowned scientists seek new and innovative ways to prevent, diagnose and treat cancer, HIV/AIDS and other life-threatening diseases. Fred Hutch’s pioneering work in bone marrow transplantation led to the development of immunotherapy, which harnesses the power of the immune system to treat cancer. An independent, nonprofit research institute based in Seattle, Fred Hutch houses the nation’s first cancer prevention research program, as well as the clinical coordinating center of the Women’s Health Initiative and the international headquarters of the HIV Vaccine Trials Network. Careers Start Here.

 

The Clinical Research Nurse will provide overall planning, management, coordination, and implementation of investigator-initiated and industry-sponsored clinical research studies, involving human subjects for the Non-Malignant Disease Transplant Program, Clinical Research Division.

Responsibilities

This individual will work under the supervision of the Principal Investigator (PI) and Director of the Non-Malignant Disease Transplant Program and will be required to perform their responsibilities with a high level of independence within the scope of study protocol(s) and institutional guidelines, and RN License Scope of Practice.


Nursing duties by category

Principal Investigator Support:

  • Complete protocol specific nursing assessments for study participants with appropriate documentation in the medical record.
  • Monitor lab results and outside medical records. Communicate clinically significant events to the PI and triage as necessary.
  • May act as sub-investigator when the principal investigator designates protocol specific responsibilities to the research nurse that are within the research nurse scope of practice.

Collaboration:

  • Identify trends in side effects and work with the principal investigator, the clinic nurse, and/or Transplant Team to develop and evaluate patient management strategies.
  • Collaborate professionally and regularly with clinic nurse, to provide seamless patient care for research participants.
  • Interact with staff at outside facilities to ensure continuity of care for research participants as well as ensure protocol requirements are met
  • Coordinate with PI, Clinic Nurses, & Pharmacists to manage side effects/adverse effects of study drugs with either concurrent medications or sponsor supplied study drugs.

Education:

  • Provide protocol specific nursing education to study participants, caregivers, and colleagues and engage in direct patient contact care and services, as appropriate.
  • Fulfill requirements of UWMC Credentialing.
  • Perform clinical procedures such as blood draws from central line catheters and peripheral sites; evaluation of skin in suspected graft vs. host disease including skin biopsies; and other procedures within RN scope of practice as necessary.
  • Administer medications, including study drugs, biologicals, and radioisotopes (with radiation safety training), according to protocol and within RN scope of practice.
  • Assess patient and monitor for side effects to study drug with appropriate response including administration of PRN medications per protocol direction and, as necessary, consultation with PI.


Clinical coordinator duties by category

Principal Investigator Support:

  • Serve as designee of the Principal Investigator (PI) to manage the daily clinical operations of assigned research studies in accordance with regulatory, GCP guidelines and institutional policy.
  • Review study candidates’ medical records for study eligibility


Enrollment, Education & Protocol Implementation:

  • Ensure informed consent, initiate patient enrollment, and ensure accurate enrollment records are maintained.
  • Educate clinical teams, ancillary departments, and patients to ensure safe and accurate protocol implementation.
  • Develop and maintain tools for study implementation, which may include data collection tools, study reference materials, and study specific orders. Revise and utilize tools as necessary to fulfill the aims of the clinical trial.
  • Initiate scheduling of patient clinic visits, and on-going study visits. Ensure clinical procedures, lab test, and other protocol specific activities are completed as outlined in the protocols.
  • Complete requisition forms, assemble kits for upcoming research visits, transport laboratory samples, and ensure samples are processed and shipped according to study specific guidelines, while tracking and maintaining research supplies.


Budget & Billing, Other duties, etc:

  • Understand clinical trial budget and billing plans for patients enrolled on clinical trials.
  • Work with internal partners to obtain and submit budget and billing information.
  • Assist the Principal Investigator (PI) with protocol development, revision, and study analysis.
  • Collaborate with Investigational Drug Services (IDS) on drug assignment, dispensation information, and maintain regular communication regarding status of study subjects.
  • Ensure study drug self-administration and accountability with patients.
  • Perform non-clinical ECGs.
  • Administer study questionnaires.
  • Function as a protocol liaison with clinical teams, patients, and when necessary, other institutions or drug companies.
  • Maintain or assist in maintaining IRB correspondence and regulatory documentation. Prepare or assist in preparing consent forms, continuation review reports, protocol modifications, and other study reports.
  • Maintain appropriate source documentation, and complete or assist with accurate data entry into case report forms in a timely manner.
  • Coordinate monitoring visits and respond to queries and other requests from study monitors.
  • Identify and report adverse events in accordance with protocol, regulatory guidelines, and institutional policy.
  • Participate in the review of charges for patients on clinical trials to ensure billing compliance.
  • Travel for industry sponsored investigator meetings.
  • Maintain thorough knowledge in the field through attending related project meetings and symposia, reading related literature, and maintaining professional associations

Qualifications

  • Must have a Bachelor’s degree and be a Licensed Registered Nurse in the State of Washington
  • Applicant must have a minimum of 10 years of nursing experience, with previous experience in hematology, oncology and/or research nursing preferred.
  • This position requires excellent organizational skills, attention to detail, ability to problem solve and to prioritize multiple competing tasks in a dynamic environment.
  • Collaborative focus is essential, as well as strong written and verbal communication skills, including computer skills.

Our Commitment to Diversity

We are committed to cultivating a workplace in which diverse perspectives and experiences are welcomed and respected. We are proud to be an Equal Opportunity and VEVRAA Employer. We do not discriminate on the basis of race, color, religion, creed, ancestry, national origin, sex, age, disability, marital or veteran status, sexual orientation, gender identity, political ideology, or membership in any other legally protected class. We are an Affirmative Action employer. We encourage individuals with diverse backgrounds to apply and desire priority referrals of protected veterans. If due to a disability you need assistance/and or a reasonable accommodation during the application or recruiting process, please send a request to our Employee Services Center at escmail@fredhutch.org or by calling 206-667-4700.

Clinical Research Nurse

FH Clinical Research Division
Category: Nursing and Nursing Support
Seattle, WA, US
Job ID: 12802

Overview

Cures Start Here. At Fred Hutchinson Cancer Research Center, home to three Nobel laureates, interdisciplinary teams of world-renowned scientists seek new and innovative ways to prevent, diagnose and treat cancer, HIV/AIDS and other life-threatening diseases. Fred Hutch’s pioneering work in bone marrow transplantation led to the development of immunotherapy, which harnesses the power of the immune system to treat cancer. An independent, nonprofit research institute based in Seattle, Fred Hutch houses the nation’s first cancer prevention research program, as well as the clinical coordinating center of the Women’s Health Initiative and the international headquarters of the HIV Vaccine Trials Network. Careers Start Here.

 

The Antibody Research Group within the Clinical Research Division has an outstanding opportunity for a 75% FTE Clinical Research Nurse. The Clinical Research Nurse will participate in the planning, coordination, and implementation of industry-sponsored clinical research studies involving innovative treatments for patients with hematologic malignancies. This position is currently funded for one year with the potential of becoming a regular position.

 

This individual will work under the supervision of the Principal Investigator (PI), Lead Clinical Research Nurse and/or Research Manager, and will be required to perform his/her/their responsibilities with a high level of independence within the scope of study protocol(s) and institutional guidelines, and RN License Scope of Practice. This position will be part of a larger research team allowing for collegial support and cross coverage.

Responsibilities

NURSING DUTIES BY CATEGORY

 

Principal Investigator Support:

  • Complete protocol specific nursing assessments for study participants with appropriate documentation in the medical record.
  • Monitor lab results and outside medical records. Communicate clinically significant events to the PI and triage as necessary.
  • May act as sub-investigator when the principal investigator designates protocol specific responsibilities to the research nurse that are within the research nurse scope of practice.

 

Collaboration:

  • Identify trends in side effects and work with the principal investigator, the clinic nurse, Transplant Team and/or outside facilities to develop and evaluate patient management strategies.
  • Collaborate professionally and regularly with clinic staff and research team members at UW, SCCA, sponsors and outside teams to provide seamless patient care for research participants.
  • Interact with staff at outside facilities to ensure continuity of care for research participants as well as ensure protocol requirements are met
  • Coordinate with PI, Clinic Nurses, & Pharmacists to manage side effects/adverse effects of study drugs with either concurrent medications or sponsor supplied study drugs.

 

Education:

  • Provide protocol specific nursing education to study participants, caregivers, and colleagues.

 

Participation in Direct Patient Care at UWMC

  • Fulfill requirements of UWMC and SCCA Credentialing.
  • Perform clinical procedures such as blood draws from central line catheters and peripheral sites; evaluation of skin in suspected graft vs. host disease including skin biopsies; and other procedures within RN scope of practice as necessary.
  • Administer medications, including study drugs, biologicals, and radioimmunoconjugates (with radiation safety training), according to protocol and within RN scope of practice.
  • Assess patient and monitor for side effects to study drug with appropriate response including administration of PRN medications per protocol and, as necessary, consultation with PI or medical care team.

 

OTHER CLINICAL RESEARCH DUTIES BY CATEGORY

 

Principal Investigator Support:

  • Serve as designee of the Principal Investigator (PI) to manage the daily clinical operations of assigned research studies in accordance with regulatory, GCP guidelines and institutional policy.
  • Review study candidates’ medical records for study eligibility.

 

Enrollment

  • Ensure informed consent, initiate patient enrollment, and ensure accurate enrollment records are maintained.

 

Education

  • Educate clinical teams, ancillary departments, and patients to ensure safe and accurate protocol implementation.

 

Protocol Implementation

  • Develop and maintain tools for study implementation, which may include data collection tools, study reference materials, and study specific orders. Revise and utilize tools as necessary to fulfill the aims of the clinical trial.
  • Initiate scheduling of patient clinic visits, and on-going study visits. Ensure clinical procedures, lab test, and other protocol specific activities are completed as outlined in the protocols.
  • Complete requisition forms, assemble kits for upcoming research visits, transport or arrange for transport of laboratory samples, and ensure samples are processed and shipped according to study specific guidelines, while tracking and maintaining research supplies.

 

Budget & Billing

  • Understand clinical trial budget and billing plans for patients enrolled on clinical trials.
  • Work with internal partners to obtain and submit budget and billing information.

 

Other Duties Which May Be Required

  • Collaborate with Nuclear Medicine and/or Investigational Drug Services (IDS) on drug assignment and dispensation information, and maintain regular communication regarding status of study subjects.
  • Function as a protocol liaison with clinical teams, patients, and when necessary, other institutions or drug companies. 
  • Maintain or assist in maintaining IRB correspondence and regulatory documentation.  Prepare or assist in preparing consent forms, continuation review reports, protocol modifications, and other study reports.
  • Maintain appropriate source documentation, and complete or assist with accurate data entry into case report forms in a timely manner. 
  • Coordinate monitoring visits and respond to queries and other requests from study monitors.
  • Identify and report adverse events in accordance with protocol, regulatory guidelines, and institutional policy.
  • Participate in the review of charges for patients on clinical trials to ensure billing compliance.
  • Travel for industry sponsored investigator meetings.
  • Maintain thorough knowledge in the field through attending related project meetings and symposia, reading related literature, and maintaining professional associations.
  • Other duties as assigned.

Qualifications

Must have a Nursing degree and be a Licensed Registered Nurse in the State of Washington.   Applicant must have a minimum of two years of nursing experience, with previous experience in hematology, oncology and/or research nursing preferred.  This position requires excellent organizational skills, attention to detail, ability to problem solve and to prioritize multiple competing tasks in a dynamic environment.  Strong candidates will have the ability to function independently and the flexibility to adapt to changes in treatment plans. Collaborative focus is essential, as well as strong written and verbal communication skills, including computer skills.

Our Commitment to Diversity

We are committed to cultivating a workplace in which diverse perspectives and experiences are welcomed and respected. We are proud to be an Equal Opportunity and VEVRAA Employer. We do not discriminate on the basis of race, color, religion, creed, ancestry, national origin, sex, age, disability, marital or veteran status, sexual orientation, gender identity, political ideology, or membership in any other legally protected class. We are an Affirmative Action employer. We encourage individuals with diverse backgrounds to apply and desire priority referrals of protected veterans. If due to a disability you need assistance/and or a reasonable accommodation during the application or recruiting process, please send a request to our Employee Services Center at escmail@fredhutch.org or by calling 206-667-4700.

Data Coordinator II

FH Clinical Research Division
Category: Administrative Support
Seattle, WA, US
Job ID: 13756

Overview

Cures Start Here. At Fred Hutchinson Cancer Research Center, home to three Nobel laureates, interdisciplinary teams of world-renowned scientists seek new and innovative ways to prevent, diagnose and treat cancer, HIV/AIDS and other life-threatening diseases. Fred Hutch’s pioneering work in bone marrow transplantation led to the development of immunotherapy, which harnesses the power of the immune system to treat cancer. An independent, nonprofit research institute based in Seattle, Fred Hutch houses the nation’s first cancer prevention research program, as well as the clinical coordinating center of the Women’s Health Initiative and the international headquarters of the HIV Vaccine Trials Network. Careers Start Here.


The Data Coordinator will work with the research team to collect and abstract clinical data from medical records and research charts, and work closely with the physicians and research staff in providing administrative, technical and data entry support for research projects.


This position must be able to work independently on multiple research projects. This position requires daily interaction with physicians, other health care personnel (e.g. nurses, patient care coordinators, patient service representatives, and medical assistants), pharmaceutical company sponsors and any other groups integral to the successful completion of the data needs for the research project.


This position is supervised by and reports to the Research Manager or Research Coordinator.

Responsibilities

  • Abstract patient/participant data from medical records and enter into study electronic data capture system in a timely manner, according to protocol reporting guidelines and contracted timelines.
  • Maintain databases and shadow charts with source documentation. Demonstrate knowledge of database definitions.
  • Identify procedural problems and communicate to the study coordinator, PI and research manager as appropriate.
  • Resolve and answer data queries in a timely manner, in collaboration with the study coordinator as applicable.
  • Develop study-specific data collection tools in accordance with database requirements.
  • In collaboration with the study coordinator, track and maintain research subject schedules based on complex protocol-specific requirements
  • In collaboration with the Investigator and study coordinator, anticipate and plan for data deadlines
  • Perform routine audits to ensure quality and completeness of the data submitted. Identify missing data and correct deficiencies.
  • Serve as a resource to investigators, subjects, and collaborating physicians, service areas and organizations with questions about study procedures and operations.
  • Assist study coordinator with scheduling monitoring visits and completing associated tasks.
  • Prepare research sample collection kits, deliver to collection sites, and assure samples are collected and routed appropriately.
  • Assist with completion and collection of regulatory documents
  • May interact with patients at study visits to collect data.
  • Perform other duties to support the research team, including archiving records of closed studies; maintaining shared drive files; requesting medical records from outside providers.
  • Keep knowledge and skills current by completing mandated training and attending meetings with the study team and the Consortium, such as the monthly coordinator meetings, disease group meetings/rounds, faculty and administrative presentations, and other opportunities of interest.
  • Other duties as assigned.

Qualifications

  • Bachelor’s degree or equivalent experience required
  • Strong computer skills and experience with data entry and databases
  • Competency in Microsoft Office software
  • Excellent attention to detail and ability to organize work
  • Ability to communicate effectively both verbally and in writing
  • Demonstrated ability to work independently, under supervision, and be a team player
  • Ability to adapt and respond appropriately to competing priorities in a fast-paced environment
  • One to two years of experience working in healthcare environment with oncology and/or research experience preferred
  • Knowledge of FDA, GCP, and NIH requirements preferred

Our Commitment to Diversity

We are committed to cultivating a workplace in which diverse perspectives and experiences are welcomed and respected. We are proud to be an Equal Opportunity and VEVRAA Employer. We do not discriminate on the basis of race, color, religion, creed, ancestry, national origin, sex, age, disability, marital or veteran status, sexual orientation, gender identity, political ideology, or membership in any other legally protected class. We are an Affirmative Action employer. We encourage individuals with diverse backgrounds to apply and desire priority referrals of protected veterans. If due to a disability you need assistance/and or a reasonable accommodation during the application or recruiting process, please send a request to our Employee Services Center at escmail@fredhutch.org or by calling 206-667-4700.

Division Administrator - Clinical Research Division

FH Clinical Research Division
Category: Executive and Management
Seattle, WA, US
Job ID: 13168

Overview

Cures Start Here. At Fred Hutchinson Cancer Research Center, home to three Nobel laureates, interdisciplinary teams of world-renowned scientists seek new and innovative ways to prevent, diagnose and treat cancer, HIV/AIDS and other life-threatening diseases. Fred Hutch’s pioneering work in bone marrow transplantation led to the development of immunotherapy, which harnesses the power of the immune system to treat cancer. An independent, nonprofit research institute based in Seattle, Fred Hutch houses the nation’s first cancer prevention research program, as well as the clinical coordinating center of the Women’s Health Initiative and the international headquarters of the HIV Vaccine Trials Network. Careers Start Here.


The Division Administrator - Clinical Research Division will oversee administrative services and manage special projects for the Clinical Research Division (CRD) and its research programs. The CRD is the largest division of Fred Hutch with 95 primary faculty, including laboratory-based and clinical/translational investigators, and staff of 635. Areas of broad responsibility will include directing CRD administration and operations, budget development and management, personnel management and human resource oversight, divisional shared resources, pre- and post-awards grants management, overall supervision of administrative personnel at the division and programmatic level, facilitating staffing support to the Division faculty, representation of the Division to the Center and community, and ensuring internal communications. This person will also work with the CRD Senior Vice President and Executive Committee in strategic planning and manage special projects within CRD, both internal and external, and including international operations as well as other projects of similar nature that may develop in the future.


The Division Administrator - Clinical Research Division will report directly to the Senior Vice President of the Clinical Research Division.

Responsibilities

Competencies:

  • Communication: Clearly and persuasively communicate, listen and seek clarifications.
  • Initiative: Work independently and as part of a team; exhibit sound and accurate judgment, including prioritization and time management skills. Provide support to multiple team members simultaneously.
  • Results Orientation: Improve processes resulting in greater effectiveness and service.
  • Detail Orientation: Demonstrate accuracy and thoroughness; monitor own work to ensure quality and organization. Strong attention to detail while multitasking.
  • Diagnostic Information Gathering: Identify the information needed to clarify situations, seek information from appropriate sources, and use skillful questioning to draw out information when others are reluctant to disclose it.
  • Follow-through: Ensure that one’s own and others’ work and information are complete and accurate; carefully prepare for meetings and presentations; follow up with others to ensure that agreements and commitments have been fulfilled.
  • Professionalism: Approach others in a tactful manner; react well under pressure; treat others with respect and consideration regardless of their status or position; accept responsibility for own actions; follow through on commitments.
  • Cultural Leadership: Foster team morale and cultivate an environment of inclusion, both within CRD and across the Center.
  • Judgment: Possess excellent business and technical judgment. Have executive maturity and ability to exercise exceptional discretion with confidential information.
  • Planning and Execution: Think holistically and strategically and execute on key operational priorities. Proven ability to plan, organize, and manage business/operational opportunities such as leadership team meetings, reviews, and events. Delegate when appropriate.
     

Job Duties:

 

Administration

  • Manage the general and non-scientific administration of the CRD and its research programs. Ensure appropriate training, mentoring and supervision of the administrative staff.
  • Serve as the liaison between research scientists and administration to support the Division and Center.
  • Oversee the development of strategic, operational and business plans associated with the Division.
  • Represent the Division on Center-wide processes and administrative committees, such as with Senior staff, Division Administrators, and administrative partnership meetings.
  • Provide administrative support for the CRD Executive Committee and other CRD committee meetings.
  • Lead and participate in division-wide planning, long-range financial planning, major equipment acquisitions, and new initiatives in conjunction with administration and colleagues in other scientific divisions.
  • Represent and advocate for Division interests via administrative partnership meetings and administrative committees, delegating as necessary.
  • Ensure current resource needs (IT, space, staff, etc.) are met and future projects needs are anticipated.
  • Perform specific duties and responsibilities on behalf of the Division Senior Vice President as requested.

 

Finance

  • Oversee the preparation, management, and monitoring of the Division's annual budget.
  • Oversee the pre- and post-award management of grants and contracts.
  • Oversee the negotiation and management of subcontracts/sub-agreements associated with the above functions.

 

Regulatory

  • Support the development of effective and compliant scientific collaborations associated with assigned projects, particularly those involving outside entities and the consortium.
  • Act as a program spokesperson in support of CRD efforts to educate other organizations including governmental entities regarding division/program operations.

 

HR Management

  • Provide HR oversight of CRD staff.
  • Provide advice and support to faculty, staff, and other Center administrative and leadership groups as requested.
  • Oversee the Division's human resource and personnel functions including annual staff and faculty merit review processes, employment requisitions and personnel actions, classification review, disciplinary actions, and staff training and development planning.

Qualifications

Required

  • A bachelor’s degree or equivalent relevant experience is required.
  • A minimum of five years of progressively responsible administrative management experience, including grant and contract budgeting, supervision, and planning in a health care, research, biotech or governmental agency environment is required.
  • Experience managing extramurally funded environments, especially NIH grant systems and industry-funded studies.
  • Knowledge and high-level experience in research administration, strategic planning and business practices are necessary.
  • The ability to manage a diverse team, think creatively and globally, project future needs, and be attuned to the day-to-day division operations is critical to success in this position.
  • Excellent interpersonal and communication skills, both verbal and written, are essential to this position.
  • The successful candidate will promote scientific excellence and be responsive to the needs of the Division and Center mission.

Preferred

  • An advanced degree in a scientific field or administration (PhD, MBA, MPA or similar) is preferred.

 

Please submit a resume, one-page cover letter, and a diversity statement to be considered for this position. Review the statement and applicant guidelines below for more information about our commitment to diversity and inclusion. Applications that do not include a Cover Letter and a Diversity Statement will not be forwarded to the search committee for consideration.

 


Diversity and Inclusion Statement

At Fred Hutch, we believe that the innovation, collaboration, and rigor that result from diversity and inclusion are critical to our mission of eliminating cancer and related diseases. We seek employees who bring new ways of seeing the world and solving problems.


Fred Hutch is committed to ensuring that all candidates hired share our commitment to diversity and inclusion. In order to identify candidates who share this vision, we request candidates submit a personal statement describing their experience and commitment to these issues of diversity and inclusion.


The search committee will consider a candidate’s statement as part of a comprehensive and transparent evaluation of their qualifications. Applications that do not include a Diversity and Inclusion Statement will not be forwarded to the search committee for consideration.


Applicant Guidelines

The Diversity and Inclusion Statement may include:

  • Description of the candidate’s commitment to diversity and inclusion.
  • Demonstration of candidate’s understanding of the importance of diversity and inclusion.
  • Description of your past efforts, as well as future plans to advance diversity, equity, and inclusion.

Preferably, candidates will leverage examples from both their personal as well as professional life. This may include how these topics are integrated into the process or fabric of your approach to operational or scientific problems or their applicability to underserved populations. Please limit responses to 250 words or less.

Our Commitment to Diversity

We are committed to cultivating a workplace in which diverse perspectives and experiences are welcomed and respected. We are proud to be an Equal Opportunity and VEVRAA Employer. We do not discriminate on the basis of race, color, religion, creed, ancestry, national origin, sex, age, disability, marital or veteran status, sexual orientation, gender identity, political ideology, or membership in any other legally protected class. We are an Affirmative Action employer. We encourage individuals with diverse backgrounds to apply and desire priority referrals of protected veterans. If due to a disability you need assistance/and or a reasonable accommodation during the application or recruiting process, please send a request to our Employee Services Center at escmail@fredhutch.org or by calling 206-667-4700.

Lab Aide (Work Study)

FH Clinical Research Division
Category: Laboratory Research Sciences
Seattle, WA, US
Job ID: 13666

Overview

Cures Start Here. At Fred Hutchinson Cancer Research Center, home to three Nobel laureates, interdisciplinary teams of world-renowned scientists seek new and innovative ways to prevent, diagnose and treat cancer, HIV/AIDS and other life-threatening diseases. Fred Hutch’s pioneering work in bone marrow transplantation led to the development of immunotherapy, which harnesses the power of the immune system to treat cancer. An independent, nonprofit research institute based in Seattle, Fred Hutch houses the nation’s first cancer prevention research program, as well as the clinical coordinating center of the Women’s Health Initiative and the international headquarters of the HIV Vaccine Trials Network. Careers Start Here.


A lab aide is needed in an immunology laboratory investigating how dynamic interactions at the level of individual cells influence disease. Using murine models, the focus of the lab is to investigate how cells of the immune system participate in the process of lung metastasis. The position will be responsible for assisting with murine husbandry, genotyping, preparing media and reagents, performing bench-level experiments, performing calculations, communicating the results of experiments, and performing other duties relating to the operation of a clinical research lab.

 

This position is eligible for work study.

Responsibilities

The individual in this position will assist with general murine husbandry including genotyping. They will also be responsible for general laboratory duties, such as preparation of lab stock solutions, lab maintenance, and emptying biohazard waste. Responsibilities include:

  • Assist with genotyping and murine husbandry
  • Prepare media and reagents, such as stock solutions
  • Restock lab supplies
  • Empty biohazard waste
  • May assist with experiments and set-up
  • Perform other related duties as assigned

Qualifications

  • A high school diploma or GED and enrollment in a university-level science degree program (e.g. biology, chemistry, or biochemistry) are required
  • Eligibility for state or federal work-study at a participating school is required
  • Previous or current coursework in biology and past laboratory experience are preferred
  • Demonstrated accuracy, attention to detail, and ability to learn new skills quickly is essential.

Our Commitment to Diversity

We are committed to cultivating a workplace in which diverse perspectives and experiences are welcomed and respected. We are proud to be an Equal Opportunity and VEVRAA Employer. We do not discriminate on the basis of race, color, religion, creed, ancestry, national origin, sex, age, disability, marital or veteran status, sexual orientation, gender identity, political ideology, or membership in any other legally protected class. We are an Affirmative Action employer. We encourage individuals with diverse backgrounds to apply and desire priority referrals of protected veterans. If due to a disability you need assistance/and or a reasonable accommodation during the application or recruiting process, please send a request to our Employee Services Center at escmail@fredhutch.org or by calling 206-667-4700.

Post-Doctoral Research Associate, Pancreas Cancer Research

FH Clinical Research Division
Category: Post-Doctoral Research Fellows and Associates
Seattle, WA, US
Job ID: 13635

Overview

Cures Start Here. Fred Hutchinson Cancer Research Center (Fred Hutch) is an independent, nonprofit research institution and home of three Nobel laureates. Fred Hutch is dedicated to the development and advancement of biomedical research to eliminate cancer and other potentially fatal diseases. Recognized internationally for its pioneering work in bone-marrow transplantation, Fred Hutch’s five scientific divisions collaborate to form a unique environment for conducting basic and applied science. Together with our clinical and research partners, the University of Washington and Seattle Children’s, we are the only National Cancer Institute-designated comprehensive cancer center in the Pacific Northwest. Careers Start Here.


A highly qualified and self-motivated Research Associate/Senior Post-Doctoral Research Fellow is sought to join the laboratory of Dr. Sunil Hingorani at Fred Hutchinson Cancer Research Center.

Responsibilities

Our laboratory investigates molecular and cellular mechanisms of pancreatic ductal adenocarcinoma (PDA) pathogenesis. The murine models of distinct genetic subtypes of pancreas cancer that we have developed form the basis of our integrated, systematic, and multidisciplinary research program. Our efforts are directed at identifying and overcoming stromal barriers to treatment (including elevated interstitial pressures, activated fibroblasts, and multiple mechanisms of immune suppression); identifying and disrupting molecular drivers of metastasis; and developing immune-based treatment strategies. Our ultimate aim is to take our discoveries and reduce them to practice in the clinic in order to radically transform the approach and prognosis for patients with this devastating disease.

Qualifications

  • Ph.D. in the field of molecular biology, biomedical engineering, biochemistry, biophysics, cancer biology, immunology or genetics
  • Demonstrated track record of at least 3 years of productive post-doctoral research experience in oncology, immune oncology and/or murine models
  • Extensive experience with fundamental techniques in molecular and cellular biology, animal studies and procedures, flow cytometry, and primary cell isolation and culture
  • Excellent communication and organizational skills are assumed
  • Experience with generation and characterization of genetically engineered murine models, advanced imaging techniques, and/or gene targeting is highly desired
  • Ability to think independently and creatively about experimental design

Our Commitment to Diversity

We are committed to cultivating a workplace in which diverse perspectives and experiences are welcomed and respected. We are proud to be an Equal Opportunity and VEVRAA Employer. We do not discriminate on the basis of race, color, religion, creed, ancestry, national origin, sex, age, disability, marital or veteran status, sexual orientation, gender identity, political ideology, or membership in any other legally protected class. We are an Affirmative Action employer. We encourage individuals with diverse backgrounds to apply and desire priority referrals of protected veterans. If due to a disability you need assistance/and or a reasonable accommodation during the application or recruiting process, please send a request to our Employee Services Center at escmail@fredhutch.org or by calling 206-667-4700.

Post-Doctoral Research Fellow, Protein Chemis/Analytical Chemist

FH Clinical Research Division
Category: Post-Doctoral Research Fellows and Associates
Seattle, WA, US
Job ID: 13861

Overview

Cures Start Here. At Fred Hutchinson Cancer Research Center, home to three Nobel laureates, interdisciplinary teams of world-renowned scientists seek new and innovative ways to prevent, diagnose and treat cancer, HIV/AIDS and other life-threatening diseases. Fred Hutch’s pioneering work in bone marrow transplantation led to the development of immunotherapy, which harnesses the power of the immune system to treat cancer. An independent, nonprofit research institute based in Seattle, Fred Hutch houses the nation’s first cancer prevention research program, as well as the clinical coordinating center of the Women’s Health Initiative and the international headquarters of the HIV Vaccine Trials Network. Careers Start Here.

 

The Paulovich Lab at Fred Hutch is an interdisciplinary team whose mission is to develop and implement tools for protein quantification to enable precision medicine (patient selection and identification of novel therapeutic targets). The lab has a major focus on mass spectrometry, especially multiple reaction monitoring. Our group is highly collaborative, participating in national and international consortia in which teams of scientists, statisticians, and clinicians work together to solve clinical or biological problems to impact human health.

 

This is a terrific opportunity for a highly motivated, interactive, Protein or Analytical Chemist to join our translational proteomics team to help drive translational projects forward towards clinical applications by performing proteomic experiments and participating in the analysis and interpretation of results.

Responsibilities

  • Process proteomic samples for LC-MS analysis (e.g., protein extraction, fractionation, immuno-depletion, trypsin digestion, alkylation, reduction, etc.)

  • Perform HPLC separations and maintain HPLC instruments

  • Work with antibodies (immunoaffinity purification, immobilization on solid supports, screening hybridomas for mass spectrometry)

  • Generate mass spectrometry (MS)-based proteomics data and maintain MS instruments

  • Contribute to the analysis of proteomic (mass spectrometry) datasets

  • Collaborate effectively with an interdisciplinary team spanning expertise in biology, analytical chemistry, and statistics

  • Collaborate with others to develop new methods and tools that support research objectives

  • Maintain research results files and databases

  • Assist with written progress reports and development of standard operating protocols (SOP)

  • Assist with writing scientific manuscripts for peer-reviewed journals

Qualifications

  • Ph.D. degree in Protein Chemistry, Analytical Chemistry, Biochemistry, or related discipline is required
  • The work is rigorously quantitative, and exquisite attention to detail and the ability to adhere to standard operating protocols (SOP) and maintaining records are critical
  • The position includes drafting reports and manuscripts for publication, as well as presenting experimental results to the research team and collaborators. Thus, excellent English writing and oral communication skills are required
  • Previous experience in a CLIA or clinical lab environment is a plus
  • A demonstrated track record of authorship on peer-reviewed journal publications is a plus

Our Commitment to Diversity

We are committed to cultivating a workplace in which diverse perspectives and experiences are welcomed and respected. We are proud to be an Equal Opportunity and VEVRAA Employer. We do not discriminate on the basis of race, color, religion, creed, ancestry, national origin, sex, age, disability, marital or veteran status, sexual orientation, gender identity, political ideology, or membership in any other legally protected class. We are an Affirmative Action employer. We encourage individuals with diverse backgrounds to apply and desire priority referrals of protected veterans. If due to a disability you need assistance/and or a reasonable accommodation during the application or recruiting process, please send a request to our Employee Services Center at escmail@fredhutch.org or by calling 206-667-4700.

Post-Doctoral Research Fellow, CAR-T Cell Immunotherapy for Hematologic Malignancy

FH Clinical Research Division
Category: Post-Doctoral Research Fellows and Associates
Seattle, WA, US
Job ID: 11852

Overview

Cures Start Here. At Fred Hutchinson Cancer Research Center, home to three Nobel laureates, interdisciplinary teams of world-renowned scientists seek new and innovative ways to prevent, diagnose and treat cancer, HIV/AIDS and other life-threatening diseases. Fred Hutch’s pioneering work in bone marrow transplantation led to the development of immunotherapy, which harnesses the power of the immune system to treat cancer. An independent, nonprofit research institute based in Seattle, Fred Hutch houses the nation’s first cancer prevention research program, as well as the clinical coordinating center of the Women’s Health Initiative and the international headquarters of the HIV Vaccine Trials Network. Careers Start Here.

The Green laboratory is focused on research developing new immunotherapeutic approaches to treat and ultimately eradicate multiple myeloma and lymphoma.

Responsibilities

The post-doctoral research fellow will work on projects in the Green Lab primarily involving laboratory based research related to the evaluation of the proliferation, function, and trafficking of chimeric antigen receptor (CAR)-T cells to treat multiple myeloma and other B-cell malignancies. In addition, studies will be conducted to determine mechanisms of tumor resistance in patients and to evaluate processes through which the efficacy of the CAR-T cell constructs can be enhanced through rational combination with agents designed to augment the immune response.

 

The successful applicant will employ strategies such as functional T cell assays, multi-parametric flow cytometry, flow sorting, DNA extraction, analysis of sequencing data, isolation of CAR-T cells from the peripheral blood and BM of treated patients, isolation of RNA for scRNA-seq studies, quantitative PCR and bioinformatics analysis. The successful applicant will work closely with members of the Riddell lab on this project.

 

The position will involve supervision of one Full-Time Research Technician and oversee the day-to-day operations of research sample activities for multiple clinical research protocols.

Qualifications

Applicants will have a PhD in a biological science and/or a MD. The ideal candidate will have a research background in immunology with robust skills in molecular and cellular biology, including significant experience with flow cytometry, and experience with T cell functional assays, DNA and RNA extraction, molecular cloning, PCR and quantitative PCR. Desirable skills include bioinformatics analysis, scientific writing and presentations.

 

To be successful in this position, the post-doctoral research fellow must be highly motivated with a track record of productive research, exemplified by first author publication(s) and presentations, and willing to work in a highly collaborative, fast paced environment. This position is suited to someone who enjoys mastering new skills, multitasking and working in a team environment.

 

This is a full-time position with a salary based on the NIH scale and excellent benefits.

Our Commitment to Diversity

We are committed to cultivating a workplace in which diverse perspectives and experiences are welcomed and respected. We are proud to be an Equal Opportunity and VEVRAA Employer. We do not discriminate on the basis of race, color, religion, creed, ancestry, national origin, sex, age, disability, marital or veteran status, sexual orientation, gender identity, political ideology, or membership in any other legally protected class. We are an Affirmative Action employer. We encourage individuals with diverse backgrounds to apply and desire priority referrals of protected veterans. If due to a disability you need assistance/and or a reasonable accommodation during the application or recruiting process, please send a request to our Employee Services Center at escmail@fredhutch.org or by calling 206-667-4700.

Post-Doctoral Research Fellow, Gene Editing in Leukemia

FH Clinical Research Division
Category: Laboratory Research Sciences
Seattle, WA, US
Job ID: 12017

Overview

Cures Start Here. At Fred Hutchinson Cancer Research Center, home to three Nobel laureates, interdisciplinary teams of world-renowned scientists seek new and innovative ways to prevent, diagnose and treat cancer, HIV/AIDS and other life-threatening diseases. Fred Hutch’s pioneering work in bone marrow transplantation led to the development of immunotherapy, which harnesses the power of the immune system to treat cancer. An independent, nonprofit research institute based in Seattle, Fred Hutch houses the nation’s first cancer prevention research program, as well as the clinical coordinating center of the Women’s Health Initiative and the international headquarters of the HIV Vaccine Trials Network. Careers Start Here.

Responsibilities

A Postdoctoral Research Fellow position is available to join the laboratory of Soheil Meshinchi in the Clinical Research Division of the Fred Hutchinson Cancer Research Center (FHCRC), Seattle, WA. The postdoctoral fellow will join an ongoing project to study the functional characteristics and biologic implications of newly discovered genomic and transcript alterations in AML. 

Qualifications

  • Suitable applicants should have a Ph.D. degree in immunology, cellular and molecular biology, or a closely-related field.
  • Significant experience with a broad range of standard molecular biology techniques involving isolation and manipulation of DNA, RNA, and cDNA; PCR; gene cloning; DNA sequencing using traditional Sanger methods; and construction of recombinant plasmid and viral vectors is essential. 
  • Experience with CRISPR/cas9 gene editing is ideal.  The candidate should also be familiar with standard assays of immune cell function and analysis such as ELISA, ELIspot, 51Cr release-based cytotoxicity assays and flow cytometry. 
  • Experience with murine models of anti-tumor cellular immune responses will also be highly desirable.
  • The successful candidate will be a scientifically driven, well-organized self-starter with a track record of effective communication of previous work in both oral and written format.

Our Commitment to Diversity

We are committed to cultivating a workplace in which diverse perspectives and experiences are welcomed and respected. We are proud to be an Equal Opportunity and VEVRAA Employer. We do not discriminate on the basis of race, color, religion, creed, ancestry, national origin, sex, age, disability, marital or veteran status, sexual orientation, gender identity, political ideology, or membership in any other legally protected class. We are an Affirmative Action employer. We encourage individuals with diverse backgrounds to apply and desire priority referrals of protected veterans. If due to a disability you need assistance/and or a reasonable accommodation during the application or recruiting process, please send a request to our Employee Services Center at escmail@fredhutch.org or by calling 206-667-4700.

Post-Doctoral Research Fellow, Hematopoiesis

FH Clinical Research Division
Category: Laboratory Research Sciences
Seattle, WA, US
Job ID: 13837

Overview

Cures Start Here. At Fred Hutchinson Cancer Research Center, home to three Nobel laureates, interdisciplinary teams of world-renowned scientists seek new and innovative ways to prevent, diagnose and treat cancer, HIV/AIDS and other life-threatening diseases. Fred Hutch’s pioneering work in bone marrow transplantation led to the development of immunotherapy, which harnesses the power of the immune system to treat cancer. An independent, nonprofit research institute based in Seattle, Fred Hutch houses the nation’s first cancer prevention research program, as well as the clinical coordinating center of the Women’s Health Initiative and the international headquarters of the HIV Vaccine Trials Network. Careers Start Here.

Responsibilities

The Silberstein lab (https://research.fhcrc.org/silberstein/en.html) is seeking to recruit a post-doctoral fellow who is interested in pursuing laboratory-based research project.

 

The main goal of the laboratory is to combine basic stem cell biology and clinically relevant murine models in order to develop new therapeutic approaches to promote HSC function in bone marrow failure and to enhance post-transplant hematopoietic reconstitution. We are particularly interested in using microenvironment-derived molecules as drugs or therapeutic targets, and discovered several novel niche factors using proximity-based single cell analysis (for details, please see Silberstein et al, Cell Stem Cell 2016, Goncalves, Silberstein et al, Cell 2016).

 

A successful candidate will be studying the effect of extrinsic HSC regulators on the bone marrow function and disease progression in preclinical models of myelodysplastic syndrome. In parallel, they will also be involved in a project which investigates the role of newly-defined niche factors in HSC aging and stress response. 

 

They will be part of a Stem Cell and Gene Therapy Program at the Fred Hutch and interact closely with other laboratories within the Program (Kiem, Adair, Bernstein, Hadland, Doulatov) and those within Integrated Immunotherapy Research Center (Dudakov, Turtle). There will be ample opportunities for data presentation and informal discussions. They will be encouraged to develop research ideas and branch out into more independent projects. Mentorship and support for post-doctoral fellowship applications will be provided. 

Qualifications

The candidate is expected to have a PhD and/or MD and a strong interest in stem cell research and commitment to basic/translational science in hematopoiesis. Applications from trainee hematologists who are willing to undertake a laboratory-based research project are welcome. Previous experience of working with murine models is not essential, but would be preferred. Proficiency in written and verbal English is required.

Our Commitment to Diversity

We are committed to cultivating a workplace in which diverse perspectives and experiences are welcomed and respected. We are proud to be an Equal Opportunity and VEVRAA Employer. We do not discriminate on the basis of race, color, religion, creed, ancestry, national origin, sex, age, disability, marital or veteran status, sexual orientation, gender identity, political ideology, or membership in any other legally protected class. We are an Affirmative Action employer. We encourage individuals with diverse backgrounds to apply and desire priority referrals of protected veterans. If due to a disability you need assistance/and or a reasonable accommodation during the application or recruiting process, please send a request to our Employee Services Center at escmail@fredhutch.org or by calling 206-667-4700.

Post-Doctoral Research Fellow, Immuno-Oncology

FH Clinical Research Division
Category: Post-Doctoral Research Fellows and Associates
Seattle, WA, US
Job ID: 13771

Overview

Cures Start Here. At Fred Hutchinson Cancer Research Center, home to three Nobel laureates, interdisciplinary teams of world-renowned scientists seek new and innovative ways to prevent, diagnose and treat cancer, HIV/AIDS and other life-threatening diseases. Fred Hutch’s pioneering work in bone marrow transplantation led to the development of immunotherapy, which harnesses the power of the immune system to treat cancer. An independent, nonprofit research institute based in Seattle, Fred Hutch houses the nation’s first cancer prevention research program, as well as the clinical coordinating center of the Women’s Health Initiative and the international headquarters of the HIV Vaccine Trials Network. Careers Start Here.

Responsibilities

Postdoctoral Research Fellows in immuno-oncology – Novel cancer immunotherapies

 

Immunotherapies, such as checkpoint inhibition and adoptive T cell therapies, represent a paradigm shift in the treatment of cancer, inducing impressive responses in diverse malignancies. However, not all patients respond to current immunotherapies and novel therapeutic approaches are needed to circumvent these obstacles.

 

Post-Doctoral Research Fellow positions are available in the Immunotherapy Integrated Research Center at the Fred Hutchinson Cancer Research Center. The successful applicants will join a collaborative team that combines clinical research, animal modeling, computational biology and multiplexed immuno-histochemistry to understand the basic mechanisms of antitumor immunity and apply them to the development of novel immunotherapies.

 

This research program includes the laboratories of: Dr. Aude Chapuis, a translational immuno-oncologist who specializes in adoptive T cell therapies; Dr. Anthony Rongvaux, an immunologist who develops innovative humanized murine models to study the tumor/immune interface; Dr. Raphael Gottardo, a biostatistician with expertise in high-dimensional single cell data analysis; and Dr. Robert Pierce, a pathologist and expert in tumor microenvironment analyses who previously developed tissue-based biomarkers for Merck’s anti-PD-1 pembrolizumab antibody.

 

Our research is focused on understanding the biology and improving clinical outcomes after immune-boosting treatments. Human adoptive immunotherapy trials are initiated and being conducted using the robust Fred Hutch clinical platform. We are performing detailed analysis of patient outcomes to inform next-generation trials. , and developing humanized murine models of checkpoint inhibition and adoptive T cell therapy against solid and liquid cancers. We are using single cell RNA sequencing, genome editing and genomic screens in humanized murine to understand how anti-tumoral immunity functions, why it fails in some patients, and how we can overcome current limitations. We use multiparametric immunohistochemistry to validate humanized mouse results in humans, using a large biorepository of annotated patient specimens.

 

The scientific questions being addressed include:

  • How can we arm tumor-specific T cells to enhance their efficacy upon adoptive transfer in patients?
  • Can we modulate the immunosuppressive properties of cells found in the tumor microenvironment, particularly macrophages?
  • Can we identify additional immune checkpoints and develop novel inhibitors?

The overall objective of this interdisciplinary project is to provide the scientific basis for future clinical trials, leveraging Fred Hutch’s continuing leadership in the design, clinical testing and commercialization of successful anticancer drugs and immunotherapies.

Qualifications

Desired skills and experience of the applicants:

  • PhD or MD/PhD degree in Immunology, Immuno-oncology, Cellular & Molecular Biology or a closely related field
  • Strong knowledge/understanding of basic immunology
  • Advanced training and experience with animal procedures, flow cytometry, primary cell isolation and culture, molecular biology and/or computational immunology

The successful candidates will be scientifically driven individuals who enjoy working in a highly collaborative environment, with a track record of productive research, demonstrated by at least one first author publication, and with excellent communication skills.

 

Please apply online with a letter summarizing previous work experience, personal strengths and future interests, a resume, and contact information for three professional references.

 


Related publications:

 

Chapuis lab:

Paulson KG, Voillet V, McAfee MS, Hunter DS, Wagener FD, Perdicchio M, Valente WJ, Koelle SJ, Church CD, Vandeven N, Thomas H, Colunga AG, Iyer JG, Yee C, Kulikauskas R, Koelle DM, Pierce RH, Bielas JH, Greenberg PD, Bhatia S, Gottardo R, Nghiem P, Chapuis AG.

Acquired cancer resistance to combination immunotherapy from transcriptional loss of class I HLA.

Nat Commun. 2018 Sep 24;9(1):3868. PMID: 30250229.

 

Chapuis AG, Desmarais C, Emerson R, Schmitt TM, Shibuya K, Lai I, Wagener F, Chou J, Roberts IM, Coffey DG, Warren E, Robbins H, Greenberg PD, Yee C.

Tracking the Fate and Origin of Clinically Relevant Adoptively Transferred CD8(+) T Cells In Vivo.

Sci Immunol. 2017 Feb;2(8). PMID: 28367538.

 

Chapuis AG, Lee SM, Thompson JA, Roberts IM, Margolin KA, Bhatia S, Sloan HL, Lai I, Wagener F, Shibuya K, Cao J, Wolchok JD, Greenberg PD, Yee C.

Combined IL-21-primed polyclonal CTL plus CTLA4 blockade controls refractory metastatic melanoma in a patient.

J Exp Med. 2016 Jun 27;213(7):1133-9. PMID: 27242164.

 

Rongvaux lab:

Rongvaux A, Willinger T, Martinek J, Strowig T, Gearty SV, Teichmann LL, Saito Y, Marches F, Halene S, Palucka AK, Manz MG, Flavell RA.

Development and function of human innate immune cells in a humanized mouse model.

Nat Biotechnol. 2014 Apr;32(4):364-72. PMID: 24633240.

 

Rongvaux A, Takizawa H, Strowig T, Willinger T, Eynon EE, Flavell RA, Manz MG.

Human hemato-lymphoid system mice: current use and future potential for medicine.

Annu Rev Immunol. 2013;31:635-674. PMID: 23330956.

 

Gottardo lab:

McDavid A, Finak G, Gottardo R.

The contribution of cell cycle to heterogeneity in single-cell RNA-seq data.

Nat Biotechnol. 2016 Jun 9;34(6):591-3. PMID: 27281413.

 

Finak G, McDavid A, Yajima M, Deng J, Gersuk V, Shalek AK, Slichter CK, Miller HW, McElrath MJ, Prlic M, Linsley PS, Gottardo R.

MAST: a flexible statistical framework for assessing transcriptional changes and characterizing heterogeneity in single-cell RNA sequencing data.

Genome Biol. 2015 Dec 10;16:278. PMID: 26653891.

 

Pierce lab:

Stromnes IM, Hulbert A, Pierce RH, Greenberg PD, Hingorani SR.

T-cell Localization, Activation, and Clonal Expansion in Human Pancreatic Ductal Adenocarcinoma.

Cancer Immunol Res. 2017 Nov;5(11):978-991. PMID: 29066497.

 

Tumeh PC, Harview CL, Yearley JH, Shintaku IP, Taylor EJ, Robert L, Chmielowski B, Spasic M, Henry G, Ciobanu V, West AN, Carmona M, Kivork C, Seja E, Cherry G, Gutierrez AJ, Grogan TR, Mateus C, Tomasic G, Glaspy JA, Emerson RO, Robins H, Pierce RH, Elashoff DA, Robert C, Ribas A.

PD-1 blockade induces responses by inhibiting adaptive immune resistance.

Nature. 2014 Nov 27;515(7528):568-71. PMID: 25428505.

Our Commitment to Diversity

We are committed to cultivating a workplace in which diverse perspectives and experiences are welcomed and respected. We are proud to be an Equal Opportunity and VEVRAA Employer. We do not discriminate on the basis of race, color, religion, creed, ancestry, national origin, sex, age, disability, marital or veteran status, sexual orientation, gender identity, political ideology, or membership in any other legally protected class. We are an Affirmative Action employer. We encourage individuals with diverse backgrounds to apply and desire priority referrals of protected veterans. If due to a disability you need assistance/and or a reasonable accommodation during the application or recruiting process, please send a request to our Employee Services Center at escmail@fredhutch.org or by calling 206-667-4700.

Post-Doctoral Research Fellow, Immunology and Bioengineering

FH Clinical Research Division
Category: Post-Doctoral Research Fellows and Associates
Seattle, WA, US
Job ID: 13287

Overview

Cures Start Here. At Fred Hutchinson Cancer Research Center, home to three Nobel laureates, interdisciplinary teams of world-renowned scientists seek new and innovative ways to prevent, diagnose and treat cancer, HIV/AIDS and other life-threatening diseases. Fred Hutch’s pioneering work in bone marrow transplantation led to the development of immunotherapy, which harnesses the power of the immune system to treat cancer. An independent, nonprofit research institute based in Seattle, Fred Hutch houses the nation’s first cancer prevention research program, as well as the clinical coordinating center of the Women’s Health Initiative and the international headquarters of the HIV Vaccine Trials Network. Careers Start Here.

Responsibilities

A Postdoctoral Research Fellow position is available immediately in the Clinical Research Division of Fred Hutch.  The successful applicant will work with Dr. Matthias Stephan to create off-the-shelf nanoreagents that genetically reprogram the body’s ability to fight tumors and infectious disease (Nature Outlook December 21, 2017).

Qualifications

Suitable applicants should have a recent PhD in immunology or a related field. The ideal candidate will work well in an interactive scientific environment, be intellectually curious, and have experience in all aspects of cellular immunology. Critical skills include extensive animal science knowledge and extensive experience with animal handling, direct, hands-on experience with, and extensive knowledge of, cellular immunology, oncology, cell-based immune functional assays, flow cytometric analysis and isolation of transformed and primary cells, modulation of tumor microenvironments, and relevant statistical analysis

Our Commitment to Diversity

We are committed to cultivating a workplace in which diverse perspectives and experiences are welcomed and respected. We are proud to be an Equal Opportunity and VEVRAA Employer. We do not discriminate on the basis of race, color, religion, creed, ancestry, national origin, sex, age, disability, marital or veteran status, sexual orientation, gender identity, political ideology, or membership in any other legally protected class. We are an Affirmative Action employer. We encourage individuals with diverse backgrounds to apply and desire priority referrals of protected veterans. If due to a disability you need assistance/and or a reasonable accommodation during the application or recruiting process, please send a request to our Employee Services Center at escmail@fredhutch.org or by calling 206-667-4700.

Post-Doctoral Research Fellow, Immunotherapy

FH Clinical Research Division
Category: Post-Doctoral Research Fellows and Associates
Seattle, WA, US
Job ID: 12846

Overview

Cures Start Here. At Fred Hutchinson Cancer Research Center, home to three Nobel laureates, interdisciplinary teams of world-renowned scientists seek new and innovative ways to prevent, diagnose and treat cancer, HIV/AIDS and other life-threatening diseases. Fred Hutch’s pioneering work in bone marrow transplantation led to the development of immunotherapy, which harnesses the power of the immune system to treat cancer. An independent, nonprofit research institute based in Seattle, Fred Hutch houses the nation’s first cancer prevention research program, as well as the clinical coordinating center of the Women’s Health Initiative and the international headquarters of the HIV Vaccine Trials Network. Careers Start Here.

 

The post-doctoral research fellow will work on independent and collaborative projects in Dr. Chapuis laboratory developing adoptive T cell immunotherapy for viral driven malignancies within the Program in Immunology and Clinical Research Division at Fred Hutchinson Cancer Research Center. The successful applicant will employ strategies for cloning T cell receptors (TCRs) and genetic modification of human T cells with TCRs specific for antigens expressed by malignancies. In vitro studies using human T cells and in vivo murine models will be used to develop and test novel T cell therapies. The research fellow will perform correlative studies to evaluate the transfer, persistence and function of antigen-specific T cells in human clinical trials of adoptive T cell immunotherapy.

 

The Program in Immunology is a leader in the development and clinical application of adoptive immunotherapy using genetically modified T cells and is committed to the advancement of this approach. The post-doctoral research fellow may also participate in the laboratory evaluation of ongoing clinical trials involving engineering of peripheral blood stem cell grafts for improved allogeneic hematopoietic stem cell transplantation outcomes, and in the development of future immunotherapy strategies. This is a full-time position with a salary based on the NIH scale and excellent benefits.

Responsibilities

  • Study the function of human T cells
  • Molecular bench work with PCR, cloning, and vector design
  • Single cell RNA sequencing
  • Biostatistics and some basic programing skills
  • Cell Culture, cell sorting, flow cytometry, intercellular staining, and transfections
  • Validation through functional and killing assays.

Qualifications

  • MD and/or a PhD in a biological science with a diverse knowledge of immunology
  • Dynamic and driven – engaging and encouraging in team environments
  • Willingness to write and apply for funding opportunities and abstracts
  • A strong research background
  • Proficient in molecular biology and cellular immunology technique and knowhow
  • Virology knowledge will assist in the AIM of this positon
  • Flow cytometry and cell signaling based assays
  • Experience in analysis of TCR signaling pathways and in lentiviral modification of T cells will be an advantage


To be successful in this position, the post-doctoral research fellow must be highly motivated and driven to establish a career as a future independent investigator, will need to be able to work independently and play well with others.

Our Commitment to Diversity

We are committed to cultivating a workplace in which diverse perspectives and experiences are welcomed and respected. We are proud to be an Equal Opportunity and VEVRAA Employer. We do not discriminate on the basis of race, color, religion, creed, ancestry, national origin, sex, age, disability, marital or veteran status, sexual orientation, gender identity, political ideology, or membership in any other legally protected class. We are an Affirmative Action employer. We encourage individuals with diverse backgrounds to apply and desire priority referrals of protected veterans. If due to a disability you need assistance/and or a reasonable accommodation during the application or recruiting process, please send a request to our Employee Services Center at escmail@fredhutch.org or by calling 206-667-4700.

Post-Doctoral Research Fellow, Immunotherapy

FH Clinical Research Division
Category: Post-Doctoral Research Fellows and Associates
Seattle, WA, US
Job ID: 13920

Overview

Cures Start Here. At Fred Hutchinson Cancer Research Center, home to three Nobel laureates, interdisciplinary teams of world-renowned scientists seek new and innovative ways to prevent, diagnose and treat cancer, HIV/AIDS and other life-threatening diseases. Fred Hutch’s pioneering work in bone marrow transplantation led to the development of immunotherapy, which harnesses the power of the immune system to treat cancer with minimal side effects. An independent, nonprofit research institute based in Seattle, Fred Hutch houses the nation’s first and largest cancer prevention research program, as well as the clinical coordinating center of the Women’s Health Initiative and the international headquarters of the HIV Vaccine Trials Network. Careers Start Here.

Responsibilities

The Turtle Lab is looking for a post-doctoral research fellow who will work on independent and collaborative projects developing adoptive T cell immunotherapy for hematologic malignancies within the Program in Immunology and Clinical Research Division at Fred Hutch. The successful applicant will employ strategies for genetic modification of human T cells to enable their expression of chimeric antigen receptors (CARs) and redirection of specificity to antigens expressed by hematologic malignancies. In vitro studies using human T cells and in vivo xenogeneic models will be used to develop and test novel T cell therapies that can be studied in future human clinical trials.

Qualifications

  • Applicants will have a PhD in a biological science and/or a MD
  • The ideal candidate will have a research background in immunology with robust skills in molecular and cellular biology, including lentiviral vector design and cloning, virus production, cell culture, flow cytometry, ELISPOT, and T cell cytotoxicity assays
  • To be successful in this position, the post-doctoral research fellow must be highly motivated to establish a career as a future independent investigator

Our Commitment to Diversity

We are committed to cultivating a workplace in which diverse perspectives and experiences are welcomed and respected. We are proud to be an Equal Opportunity and VEVRAA Employer. We do not discriminate on the basis of race, color, religion, creed, ancestry, national origin, sex, age, disability, marital or veteran status, sexual orientation, gender identity, political ideology, or membership in any other legally protected class. We are an Affirmative Action employer. We encourage individuals with diverse backgrounds to apply and desire priority referrals of protected veterans. If due to a disability you need assistance/and or a reasonable accommodation during the application or recruiting process, please send a request to our Employee Services Center at escmail@fredhutch.org or by calling 206-667-4700.

Post-Doctoral Research Fellow, Pancreatic Cancer Research

FH Clinical Research Division
Category: Post-Doctoral Research Fellows and Associates
Seattle, WA, US
Job ID: 11911

Overview

Cures Start Here. Fred Hutchinson Cancer Research Center (Fred Hutch), home of three Nobel laureates, is an independent, nonprofit research institution dedicated to the development and advancement of biomedical research to eliminate cancer and other potentially fatal diseases. Recognized internationally for its pioneering work in bone-marrow transplantation, Fred Hutch’s five scientific divisions collaborate to form a unique environment for conducting basic and applied science. The Fred Hutch, in collaboration with its clinical and research partners, the University of Washington and Seattle Children’s, is the only National Cancer Institute-designated comprehensive cancer center in the Pacific Northwest. Careers Start Here.

Responsibilities

A highly qualified and motivated post-doctoral research fellow is sought to join the laboratory of Dr. Sunil Hingorani (https://research.fhcrc.org/hingorani/en.html) at Fred Hutchinson Cancer Research Center in Seattle, WA.

 

Our laboratory investigates molecular and cellular mechanisms of pancreatic ductal adenocarcinoma (PDA) pathogenesis.  The murine models of distinct genetic subtypes of pancreas cancer that we have developed form the basis of our integrated, systematic, and multidisciplinary research program.  Our efforts are directed at identifying and overcoming stromal barriers to treatment (including elevated interstitial pressures, activated fibroblasts, and multiple mechanisms of immune suppression); identifying and disrupting molecular drivers of metastasis; and developing immune-based strategies.  Our ultimate aim is to reduce our discoveries to practice in the clinic in order to radically transform the approach and prognosis for patients with this devastating disease.

Qualifications

Successful applicants will have:

  • A Ph.D. in the field of molecular biology, biomedical engineering, biochemistry, biophysics, cancer biology, immunology or genetics
  • Experience with standard molecular and cellular biology techniques
  • A demonstrated track record of productive research
  • Experience with generation and characterization of genetically engineered murine models, advanced imaging techniques, and/or gene targeting is highly desired
  • Ability to develop create approaches to experimental design
  • Ability to work both independently and as part of a laboratory team  

Our Commitment to Diversity

We are committed to cultivating a workplace in which diverse perspectives and experiences are welcomed and respected. We are proud to be an Equal Opportunity and VEVRAA Employer. We do not discriminate on the basis of race, color, religion, creed, ancestry, national origin, sex, age, disability, marital or veteran status, sexual orientation, gender identity, political ideology, or membership in any other legally protected class. We are an Affirmative Action employer. We encourage individuals with diverse backgrounds to apply and desire priority referrals of protected veterans. If due to a disability you need assistance/and or a reasonable accommodation during the application or recruiting process, please send a request to our Employee Services Center at escmail@fredhutch.org or by calling 206-667-4700.

Post-Doctoral Research Fellow, Stem Cell Computational Biology

FH Clinical Research Division
Category: Laboratory Research Sciences
Seattle, WA, US
Job ID: 11741

Overview

Cures Start Here. At Fred Hutchinson Cancer Research Center, home to three Nobel laureates, interdisciplinary teams of world-renowned scientists seek new and innovative ways to prevent, diagnose and treat cancer, HIV/AIDS and other life-threatening diseases. Fred Hutch’s pioneering work in bone marrow transplantation led to the development of immunotherapy, which harnesses the power of the immune system to treat cancer. An independent, nonprofit research institute based in Seattle, Fred Hutch houses the nation’s first cancer prevention research program, as well as the clinical coordinating center of the Women’s Health Initiative and the international headquarters of the HIV Vaccine Trials Network. Careers Start Here.

 

The Hadland Lab (http://research.fhcrc.org/hadland/en.html) is seeking a talented postdoctoral fellow interested in studying the mechanisms regulating hematopoietic stem cell (HSC) emergence. The focus of our lab is to unravel the dynamic intercellular interactions and signal pathways governing the generation of blood and immune cells during embryonic development, and in turn apply this knowledge toward engineering novel approaches for the study and treatment of blood and immune disorders.

Responsibilities

This is a basic science position that focuses on utilizing emerging single cell technologies and computational approaches for the functional and molecular analysis of the dynamics of HSC development.  The position will also provide opportunities to develop novel translational applications in the areas of gene and cellular therapies, disease modeling, and/or drug discovery, and for collaborations with colleagues in Genome Sciences, Bioengineering, and other departments.  This position is ideally suited for a candidate who is an independent thinker but who also enjoys working collaboratively across disciplines.

Qualifications

  • PhD in a relevant field (molecular biology, cell biology, genome sciences, developmental biology, immunology, or related fields).
  • Track record of productive research, with high quality first-author publications.
  • Experience in molecular biology and cell culture techniques is required.
  • Experience in bioinformatics and use of computational algorithms to address complex biological questions is desired.
  • Additional experience in culture and differentiation of pluripotent stem cells, flow cytometry, viral transfection, gene editing, transcriptomics/proteomics, immunohistochemistry, and/or microscopy is a plus.
  • Excellent verbal and written communication skills are essential.

Our Commitment to Diversity

We are committed to cultivating a workplace in which diverse perspectives and experiences are welcomed and respected. We are proud to be an Equal Opportunity and VEVRAA Employer. We do not discriminate on the basis of race, color, religion, creed, ancestry, national origin, sex, age, disability, marital or veteran status, sexual orientation, gender identity, political ideology, or membership in any other legally protected class. We are an Affirmative Action employer. We encourage individuals with diverse backgrounds to apply and desire priority referrals of protected veterans. If due to a disability you need assistance/and or a reasonable accommodation during the application or recruiting process, please send a request to our Employee Services Center at escmail@fredhutch.org or by calling 206-667-4700.

Post-Doctoral Research Fellow, Translational Gene Therapy

FH Clinical Research Division
Category: Laboratory Research Sciences
Seattle, WA, US
Job ID: 13197

Overview

Cures Start Here. At Fred Hutchinson Cancer Research Center, home to three Nobel laureates, interdisciplinary teams of world-renowned scientists seek new and innovative ways to prevent, diagnose and treat cancer, HIV/AIDS and other life-threatening diseases. Fred Hutch’s pioneering work in bone marrow transplantation led to the development of immunotherapy, which harnesses the power of the immune system to treat cancer. An independent, nonprofit research institute based in Seattle, Fred Hutch houses the nation’s first cancer prevention research program, as well as the clinical coordinating center of the Women’s Health Initiative and the international headquarters of the HIV Vaccine Trials Network. Careers Start Here.

Responsibilities

A Stem Cell and Gene Therapy Program laboratory that studies hematopoietic stem cell biology and develops novel gene therapy and gene editing strategies is recruiting a postdoctoral fellow to develop novel in vivo gene therapy approaches for the modification of primary hematopoietic stem cells using preclinical animal models. The position involves responsibilities, such as the development and optimization of viral vector and nanoparticle formulations, follow up analyses for tracking of modified cells after delivery of the vector or formulation, processing of primary tissue samples, and culture/analysis of cells modified with nanoparticles and/or viruses. The candidate will be expected to publish and present their work in both internal and external events.

Qualifications

A PhD or MD in a scientific field is required. The individual must possess knowledge of hematopoietic stem cell biology. Experience in animal models, transduction of primary cells with viral vectors and gene therapy and editing tools are required. Experience is preferred in one or more of the following areas: hematopoietic stem cell cultures/model systems, nanoparticle technology, flow cytometry/flow-assisted cell sorting, and/or molecular biology techniques e.g. quantitative PCR. Previous experience in basic bioinformatics, and/or GLP/GMP techniques is desired, but not required.

 

To be successful in this position, the candidate must be highly motivated and able to work independently to design and execute experiments, possess a high level of initiative and attention to detail, and must also be able to multi-task and prioritize work at short notice. They must also be capable of working independently in a team environment. Candidates with excellent organizational skills and communication skills (written and oral) are encouraged to apply.

Our Commitment to Diversity

We are committed to cultivating a workplace in which diverse perspectives and experiences are welcomed and respected. We are proud to be an Equal Opportunity and VEVRAA Employer. We do not discriminate on the basis of race, color, religion, creed, ancestry, national origin, sex, age, disability, marital or veteran status, sexual orientation, gender identity, political ideology, or membership in any other legally protected class. We are an Affirmative Action employer. We encourage individuals with diverse backgrounds to apply and desire priority referrals of protected veterans. If due to a disability you need assistance/and or a reasonable accommodation during the application or recruiting process, please send a request to our Employee Services Center at escmail@fredhutch.org or by calling 206-667-4700.

Program Assistant I / II

FH Clinical Research Division
Category: Clinical Research Support Services
Seattle, WA, US
Job ID: 13907

Overview

Cures Start Here. At Fred Hutchinson Cancer Research Center, home to three Nobel laureates, interdisciplinary teams of world-renowned scientists seek new and innovative ways to prevent, diagnose and treat cancer, HIV/AIDS and other life-threatening diseases. Fred Hutch’s pioneering work in bone marrow transplantation led to the development of immunotherapy, which harnesses the power of the immune system to treat cancer. An independent, nonprofit research institute based in Seattle, Fred Hutch houses the nation’s first cancer prevention research program, as well as the clinical coordinating center of the Women’s Health Initiative and the international headquarters of the HIV Vaccine Trials Network. Careers Start Here.


The Program in Transplantation Biology in the Clinical Research Division is seeking research support person to assist in monitoring for the non-myeloablative transplant program. The Program Assistant will work under the supervision of the Principal Investigators and Research Staff Manager to assist in coordinating research activities with the Patient Care Teams or local MDs, data entry, specimen tracking, document review, and regulatory support for non-myeloablative and myeloablative hematopoietic cell transplant protocols.

Responsibilities

  • Review patient records and update patient database
  • Assist in coordination of patient disease restaging, research specimens, and appointments with the Seattle Cancer Care Alliance and local MDs
  • Assist with protocol needs for patients seen by Seattle Cancer Care Alliance and LTFU Department
  • Assist with outside Center support
  • Deliver documents, kits, and other research support items between campus buildings
  • Case report form data entry
  • Assist with regulatory support
  • Perform other duties, as assigned

Qualifications

Minimum qualifications:

  • A bachelor’s degree with a minimum of one year experience in a medical, scientific, or research setting desirable
  • The equivalent combination of education and experience is acceptable.
  • Strong attention to detail and excellent organizational skills are essential
  • Ability to provide consistency across complex documents
  • Advanced knowledge of Access database highly desirable; MS Office Suite
  • Experience working in a group setting
  • Ability to handle high volume work load

Our Commitment to Diversity

We are committed to cultivating a workplace in which diverse perspectives and experiences are welcomed and respected. We are proud to be an Equal Opportunity and VEVRAA Employer. We do not discriminate on the basis of race, color, religion, creed, ancestry, national origin, sex, age, disability, marital or veteran status, sexual orientation, gender identity, political ideology, or membership in any other legally protected class. We are an Affirmative Action employer. We encourage individuals with diverse backgrounds to apply and desire priority referrals of protected veterans. If due to a disability you need assistance/and or a reasonable accommodation during the application or recruiting process, please send a request to our Employee Services Center at escmail@fredhutch.org or by calling 206-667-4700.

Program Assistant III - Clinical Trials

FH Clinical Research Division
Category: Clinical Research Support Services
Seattle, WA, US
Job ID: 13119

Overview

Cures Start Here. At Fred Hutchinson Cancer Research Center, home to three Nobel laureates, interdisciplinary teams of world-renowned scientists seek new and innovative ways to prevent, diagnose and treat cancer, HIV/AIDS and other life-threatening diseases. Fred Hutch’s pioneering work in bone marrow transplantation led to the development of immunotherapy, which harnesses the power of the immune system to treat cancer. An independent, nonprofit research institute based in Seattle, Fred Hutch houses the nation’s first cancer prevention research program, as well as the clinical coordinating center of the Women’s Health Initiative and the international headquarters of the HIV Vaccine Trials Network. Careers start here.


The Clinical Trials Assistant will provide administrative support to the Clinical Trials Research Manager, the Clinical Trials Finance Manager, and the Regulatory Affairs Lead within the Clinical Division. This position will further maximize efficiencies by helping to coordinate the financial and regulatory needs of new projects (primarily industry-sponsored) as well as completing day-to-day administrative tasks.  The position will report to the Research Manager.

Responsibilities

  • Complete processes associated with the development of clinical trial budgets
  • Assist with the submission of new applications for IRB review and the preparation of associated regulatory documents
  • Maintain reports utilized by the Managers to monitor activity, workloads and timelines
  • Schedule meetings, take minutes, manage supply ordering and inventory, obtain signatures, and other administrative tasks

Qualifications

Minimum:

  • BA/BS in a related field of study. Minimum three years experience in a related field.
  • Excellent time management and organizational skills
  • Ability to effectively collaborate and problem-solve with peers, staff within other departments and organizations, sponsors, and faculty
  • Strong computer skills with the ability to learn new applications quickly
  • Strong verbal and written communication skills
  • Independent motivation to support attainment of individual and group goals
  • Enjoyment of a fast-paced environment


Desired:

  • Experience with clinical trial regulatory standards and practices
  • Experience with budgeting and funds management
  • Knowledge of medical/oncology terminology
  • Experience with medical billing and some knowledge of associated regulations

Our Commitment to Diversity

We are committed to cultivating a workplace in which diverse perspectives and experiences are welcomed and respected. We are proud to be an Equal Opportunity and VEVRAA Employer. We do not discriminate on the basis of race, color, religion, creed, ancestry, national origin, sex, age, disability, marital or veteran status, sexual orientation, gender identity, political ideology, or membership in any other legally protected class. We are an Affirmative Action employer. We encourage individuals with diverse backgrounds to apply and desire priority referrals of protected veterans. If due to a disability you need assistance/and or a reasonable accommodation during the application or recruiting process, please send a request to our Employee Services Center at escmail@fredhutch.org or by calling 206-667-4700.

Regulatory and Research Coordinator

FH Clinical Research Division
Category: Clinical Research Support Services
Seattle, WA, US
Job ID: 13107

Overview

Cures Start Here. At Fred Hutchinson Cancer Research Center, home to three Nobel laureates, interdisciplinary teams of world-renowned scientists seek new and innovative ways to prevent, diagnose and treat cancer, HIV/AIDS and other life-threatening diseases. Fred Hutch’s pioneering work in bone marrow transplantation led to the development of immunotherapy, which harnesses the power of the immune system to treat cancer. An independent, nonprofit research institute based in Seattle, Fred Hutch houses the nation’s first cancer prevention research program, as well as the clinical coordinating center of the Women’s Health Initiative and the international headquarters of the HIV Vaccine Trials Network. Careers Start Here.

 

Join the Bleakley clinical research team and be at the forefront of stem cell transplantation and immunotherapy research. Under the supervision of Principal Investigator Marie Bleakley, MD/PhD, this position is responsible for coordinating research activities and managing data for leukemia patients undergoing transplantation on clinical trials. This role involves primarily responsibilities of a regulatory coordinator and also elements of research coordination, data entry and clinical trial implementation. The successful candidate will perform their responsibilities with a high level of independence and collaboratively within the scope of study protocols and institutional guidelines.

This position works in collaboration with the clinical research nurse and other members of the clinical research team on a set of transplantation protocols studying naïve T cell depletion of peripheral blood stem cell grafts. The patient population includes both pediatrics and adults from around the globe that come to Fred Hutch, SCCA, UWMC and Seattle Children’s Hospital for cutting edge research and treatment. The position includes interaction with the clinical care teams, researchers, and other support staff within and outside of the Fred Hutch/SCCA/UW/SCH system.

 

The regulatory and research coordinator position will be approximately 60% regulatory, 20% data, 10% implementation and 10% clinical research coordination.

Responsibilities

The incumbent works both independently and within a highly collaborative team while performing work assignments, and uses judgment in data monitoring and collection, quality control, co-ordination and liaison activities. Demonstrates initiative and sound judgment in problem solving, providing regulatory guidance and in developing policies and procedures. Has significant interaction with the PI(s), other team members, internal departments and external organizations and agencies.

 

60% Regulatory:


• Prepare, track and maintain all correspondence and regulatory documentation required by the IRB, FDA and other institutional and federal oversight committees, including drafting and reviewing content as appropriate
• Submit all regulatory documents to the IRB and other governing bodies to maintain study compliance with GCP, institutional and federal regulations
• Maintain study regulatory binders and files
• Perform internal audit and quality assurance checks on regulatory documents
• With input from PI(s), draft initial clinical research trial informed consent forms
• Assist study start-up: prepare and submit all required regulatory documents for new study applications; successfully open new studies from inception to accrual
• Assist in preparing and presenting materials for monitoring visits
• Assist with follow-up and resolve all issues related to regulatory concerns identified during monitoring visits
• Prepare and submit modifications/amendments and continuing renewals for ongoing study maintenance
• Conduct study close-out
• Process IND external safety reports; maintain documentation of PI review and submit/escalate safety reports as appropriate
• Report non-compliance and unanticipated problems to IRB as applicable
• Serve as liaison for internal regulatory bodies (IRB, Clinical Research Support, Regulatory Affairs, etc.)
• Stay abreast of new impacts/areas of knowledge and regulatory changes and disseminate this knowledge to the study/operations team


20% Data, 10% Implementation, 10% Clinical Research Coordinator


• Review and monitor patient clinical trial data
• Maintain protocol databases and ensure timely electronic data capture and review
• Review patient medical records and other related documentation to assist with protocol eligibility determination
• Thorough understanding of all protocol-required monitoring, data collection and reporting requirements
• Monitor patient response to therapy and review for adverse events
• Collaborate with the Clinical Research Nurse to investigate possible protocol deviations and promptly resolve potential clinical concerns
• Monitor adherence to protocol, investigating any violation
• Coordinate research and clinical operations activities to ensure protocol compliance
• Oversee biospecimen tracking and collection of protocol-specific data after patients return to their outside provider
• Organize, coordinate and oversee specimen shipments from outside institutions to the research laboratories
• Assist in the planning and content of reports to the DSMB, IRB, FDA and publications
• Coordinate special projects
• Perform other duties as assigned

Qualifications

• Bachelor's Degree in a related field; relevant experience in lieu of degree acceptable
• 1-2 years' experience in clinical research and/or regulatory, human research protection or related experience
• Demonstrated knowledge of regulatory guidelines (IRB, IACUC, MUA, etc.)
• Knowledge of FDA, GCP, and NIH requirements
• Strong computer skills and experience working with databases
• Strong verbal and written communication skills essential
• Experience in protocol implementation is desirable
• Knowledge of medical terminology preferred

Our Commitment to Diversity

We are committed to cultivating a workplace in which diverse perspectives and experiences are welcomed and respected. We are proud to be an Equal Opportunity and VEVRAA Employer. We do not discriminate on the basis of race, color, religion, creed, ancestry, national origin, sex, age, disability, marital or veteran status, sexual orientation, gender identity, political ideology, or membership in any other legally protected class. We are an Affirmative Action employer. We encourage individuals with diverse backgrounds to apply and desire priority referrals of protected veterans. If due to a disability you need assistance/and or a reasonable accommodation during the application or recruiting process, please send a request to our Employee Services Center at escmail@fredhutch.org or by calling 206-667-4700.

Research Technician I, T Cell Biology

FH Clinical Research Division
Category: Laboratory Research Sciences
Seattle, WA, US
Job ID: 13921

Overview

Cures Start Here. At Fred Hutchinson Cancer Research Center, home to three Nobel laureates, interdisciplinary teams of world-renowned scientists seek new and innovative ways to prevent, diagnose and treat cancer, HIV/AIDS and other life-threatening diseases. Fred Hutch’s pioneering work in bone marrow transplantation led to the development of immunotherapy, which harnesses the power of the immune system to treat cancer with minimal side effects. An independent, nonprofit research institute based in Seattle, Fred Hutch houses the nation’s first and largest cancer prevention research program, as well as the clinical coordinating center of the Women’s Health Initiative and the international headquarters of the HIV Vaccine Trials Network. Careers Start Here.

 

The Program of Immunology and Clinical Research Division is seeking a highly motivated and dynamic individual to work in the pre-clinical research laboratory of Dr. Chapuis.

Responsibilities

  • Isolate lymphocytes from blood and generate human T cell lines and clones
  • Process patient samples from research protocols
  • Maintain good cell culture practices and sterile technique
  • Molecular techniques including DNA extraction and manipulation, cloning and bacteria cultures, PCR
  • Potential to expand into sophisticated protocols including single cell RNA sequencing
  • Opportunity to interact with research participants; work closely with research coordinators and clinicians to coordinate clinical samples
  • Maintain meticulous records, organization
  • Clearly communicate experimental progress and results
  • General lab maintenance and organization
  • Sample management 

Qualifications

  • A bachelor’s degree in a biological science or related field and prior bench research experience required; basic immunology course work preferred
  • Experience preferred in tissue culture, flow cytometry, and molecular techniques (PCR, DNA sequencing, molecular cloning, viral vector construction, western blotting)
  • Excellent written and verbal communication skills,
  • Fluency with mathematics including scientific units and Microsoft Office software
  • Motivation, enthusiasm, demonstrated reliability, self-sufficiency, professionalism, and ability to work closely with a large and diverse team
  • Individuals with an interest in a long-term career in biomedical research and/or medicine are especially encouraged to apply

Our Commitment to Diversity

We are committed to cultivating a workplace in which diverse perspectives and experiences are welcomed and respected. We are proud to be an Equal Opportunity and VEVRAA Employer. We do not discriminate on the basis of race, color, religion, creed, ancestry, national origin, sex, age, disability, marital or veteran status, sexual orientation, gender identity, political ideology, or membership in any other legally protected class. We are an Affirmative Action employer. We encourage individuals with diverse backgrounds to apply and desire priority referrals of protected veterans. If due to a disability you need assistance/and or a reasonable accommodation during the application or recruiting process, please send a request to our Employee Services Center at escmail@fredhutch.org or by calling 206-667-4700.

Research Technician I-II, Hematopoiesis

FH Clinical Research Division
Category: Laboratory Research Sciences
Seattle, WA, US
Job ID: 13836

Overview

Cures Start Here. At Fred Hutchinson Cancer Research Center, home to three Nobel laureates, interdisciplinary teams of world-renowned scientists seek new and innovative ways to prevent, diagnose and treat cancer, HIV/AIDS and other life-threatening diseases. Fred Hutch’s pioneering work in bone marrow transplantation led to the development of immunotherapy, which harnesses the power of the immune system to treat cancer. An independent, nonprofit research institute based in Seattle, Fred Hutch houses the nation’s first cancer prevention research program, as well as the clinical coordinating center of the Women’s Health Initiative and the international headquarters of the HIV Vaccine Trials Network. Careers Start Here.

Responsibilities

The Silberstein lab is seeking to recruit a Research Technician I-II.


The main goal of the laboratory is to combine basic stem cell biology and clinically relevant murine models in order to develop new therapeutic approaches to promote hematopoietic stem cell function in bone marrow failure and to enhance hematopoietic reconstitution after bone marrow transplantation. We are particularly interested in using microenvironment-derived molecules as drugs or therapeutic targets, and have identified several novel niche factors using proximity-based single cell analysis as a discovery strategy (for details, please see Silberstein et al, Cell Stem Cell 2016, Goncalves, Silberstein et al, Cell 2016).


A successful candidate will be responsible for maintaining the murine colony and conducting animal experiments which involve stem cell transplantation, fluorescently-activated cell sorting/analysis and molecular studies of stem cells/progenitors.


The incumbent will be part of a Stem Cell and Gene Therapy Program at the Fred Hutch and interact closely with other laboratories within the Program (Kiem, Adair, Bernstein, Hadland, Doulatov) and those within Integrated Immunotherapy Research Center (Dudakov, Turtle).

Qualifications

Research Technician I required qualifications: Bachelor's degree in a related scientific discipline and prior research laboratory experience.

 

Research Technician II required qualifications: Bachelor's degree in a related scientific discipline and 2 or more years of relevant professional research experience. A Master's degree in a relevant scientific discipline can substitute for 2 years of professional research experience.

 

The candidate must have an interest in stem cell research. Applications from candidates considering medical/graduate schools are encouraged. Previous experience of working with murine models is not essential, but the position requires that a candidate handle the animals on a daily basis and perform standard animal procedures (appropriate training will be provided). Excellent written and verbal communication skills are required.

Our Commitment to Diversity

We are committed to cultivating a workplace in which diverse perspectives and experiences are welcomed and respected. We are proud to be an Equal Opportunity and VEVRAA Employer. We do not discriminate on the basis of race, color, religion, creed, ancestry, national origin, sex, age, disability, marital or veteran status, sexual orientation, gender identity, political ideology, or membership in any other legally protected class. We are an Affirmative Action employer. We encourage individuals with diverse backgrounds to apply and desire priority referrals of protected veterans. If due to a disability you need assistance/and or a reasonable accommodation during the application or recruiting process, please send a request to our Employee Services Center at escmail@fredhutch.org or by calling 206-667-4700.

Research Technician I-II, T Cell Immunotherapy

FH Clinical Research Division
Category: Laboratory Research Sciences
Seattle, WA, US
Job ID: 13848

Overview

Cures Start Here. At Fred Hutchinson Cancer Research Center, home to three Nobel laureates, interdisciplinary teams of world-renowned scientists seek new and innovative ways to prevent, diagnose and treat cancer, HIV/AIDS and other life-threatening diseases. Fred Hutch’s pioneering work in bone marrow transplantation led to the development of immunotherapy, which harnesses the power of the immune system to treat cancer. An independent, nonprofit research institute based in Seattle, Fred Hutch houses the nation’s first and largest cancer prevention research program, as well as the clinical coordinating center of the Women’s Health Initiative and the international headquarters of the HIV Vaccine Trials Network. Careers Start Here.

 

We are looking for a highly motivated individual to support the development of immunotherapy for cancer. The successful candidate will utilize a variety of cutting-edge cellular and molecular techniques to analyze T cell immunity to cancer. The technician will be closely involved in the preclinical development of new TCR-based therapies and their translation into clinical trials. The candidate should be capable of maintaining detailed laboratory records, analyzing data, and reporting experimental results. 

Responsibilities

The technician will assist in the design, implementation and interpretation of experiments involving human T lymphocytes engineered to target tumor cells. These studies are specifically aimed at identifying ways to increase the therapeutic activity of tumor-reactive T lymphocytes.

  • Perform tissue culture and molecular biology techniques: Generation of antigen-specific T cells, transduction with retroviral and lentiviral vectors, FACS sorting and expanding cells in vitro
  • Analyze T cell phenotype and function using techniques including flow cytometry, proliferation assays, PCR, RT-PCR, sequencing, and T cell cytolytic assays
  • Some murine work may be necessary in the future, with the assistance of dedicated murine technicians
  • Assist with the management and organization of a fast-paced lab. Other duties as assigned by supervisor will be performed as necessary including conducting literature reviews to assist in determining most suitable methods to be used in research.
  • Contribute to the preparation and presentation of written or oral progress reports concerning studies and assist in publication of results

Qualifications

Minimum qualifications:

  • Tech I level: A bachelor's degree in a biological field and prior research laboratory experience.
  • Tech II level: A bachelor’s degree in a biological field and two years or more of post-bachelor’s research laboratory experience
  • Molecular biology experience is required
  • To succeed in this position candidate must enjoy working independently but be able to interact well in a team environment.
  • Excellent organizational and interpersonal skills, the ability to multi-task, and attention to detail are critical. 

 

Preferred qualifications:

  • Molecular biology experience including cloning, retroviral/lentiviral transduction.
  • Immunology background with experience in aseptic cell culture techniques, multi-color flow cytometry and in establishing and maintaining primary human T cells is preferred.
  • Master’s degree providing immunology training and/or relevant technical expertise a plus.
  • Computer skills: Microsoft Excel, Prism (Graphpad), FlowJo and statistical programs for data analysis.

Our Commitment to Diversity

We are committed to cultivating a workplace in which diverse perspectives and experiences are welcomed and respected. We are proud to be an Equal Opportunity and VEVRAA Employer. We do not discriminate on the basis of race, color, religion, creed, ancestry, national origin, sex, age, disability, marital or veteran status, sexual orientation, gender identity, political ideology, or membership in any other legally protected class. We are an Affirmative Action employer. We encourage individuals with diverse backgrounds to apply and desire priority referrals of protected veterans. If due to a disability you need assistance/and or a reasonable accommodation during the application or recruiting process, please send a request to our Employee Services Center at escmail@fredhutch.org or by calling 206-667-4700.

Research Technician II / III, Pancreas Cancer

FH Clinical Research Division
Category: Laboratory Research Sciences
Seattle, WA, US
Job ID: 13881

Overview

Cures Start Here. At Fred Hutchinson Cancer Research Center, home to three Nobel laureates, interdisciplinary teams of world-renowned scientists seek new and innovative ways to prevent, diagnose and treat cancer, HIV/AIDS and other life-threatening diseases. Fred Hutch’s pioneering work in bone marrow transplantation led to the development of immunotherapy, which harnesses the power of the immune system to treat cancer. An independent, nonprofit research institute based in Seattle, Fred Hutch houses the nation’s first cancer prevention research program, as well as the clinical coordinating center of the Women’s Health Initiative and the international headquarters of the HIV Vaccine Trials Network. Careers Start Here.

 

The Hingorani Laboratory investigates molecular and cellular mechanisms of pancreatic ductal adenocarcinoma (PDA) pathogenesis. The murine models of distinct genetic subtypes of pancreas cancer that we have developed form the basis of our integrated, systematic, and multidisciplinary research program. Our efforts are directed at identifying and overcoming stromal barriers to treatment (including elevated interstitial pressures, activated fibroblasts, and multiple mechanisms of immune suppression); identifying and disrupting molecular drivers of metastasis; and developing immune-based treatment strategies. Our ultimate aim is to take our discoveries and reduce them to practice in the clinic in order to radically transform the approach and prognosis for patients with this devastating disease.

 

This Research Technician II or III position represents an excellent opportunity for an experienced, highly motivated individual with a passion for science to work and learn in a dynamic scientific environment while addressing important problems relevant for the successful treatment of cancer.

Responsibilities

The research technician will be involved in all aspects of murine preclinical studies including but not limited to breeding, genotyping, ultrasound and other imaging techniques, agent injections and administration, and performing necropsies to obtain tissues for histology and cell lines. The technician may be involved in derivation, maintenance and study of primary cell lines; isolation of DNA, RNA, and proteins; as well as other techniques such as FACS sorting and expanding cells in vitro, analyzing cell phenotype and function using techniques including flow cytometry, proliferation assays, cytotoxicity assays, PCR, RT-PCR, sequencing, and ELISpot. Molecular techniques used in the lab include cloning, transfection/transduction of cell lines, gene targeting and northern and Southern blotting. Biochemical and cellular techniques include SDS-PAGE, western blotting, immunofluorescence, and immunohistochemistry. The technician will also assist with the management and organization of a fast-paced lab, and perform other duties as assigned by supervisor.

Qualifications

Research Technician II required qualifications: Bachelor's degree in a related scientific discipline and 2 or more years of relevant professional research laboratory experience.

 

Research Technician III required qualifications: Bachelor's degree in a related scientific discipline and 5 or more years of relevant professional research laboratory experience. A Master's degree in a relevant scientific discipline can substitute for 2 years of professional research experience.

 

  • Experience with small animal surgeries and injections, cell tissue culture, flow cytometry, and molecular biology techniques are required.
  • Experience with genetically engineered murine models of pancreas cancer or other solid tumors is desired
  • Computer skills: Microsoft Excel, Prism (Graphpad), FlowJo, and statistical programs for data analysis
  • Excellent organizational and interpersonal skills are required
  • Strong troubleshooting skills and the ability to multi-task with precise attention to detail is especially critical

Our Commitment to Diversity

We are committed to cultivating a workplace in which diverse perspectives and experiences are welcomed and respected. We are proud to be an Equal Opportunity and VEVRAA Employer. We do not discriminate on the basis of race, color, religion, creed, ancestry, national origin, sex, age, disability, marital or veteran status, sexual orientation, gender identity, political ideology, or membership in any other legally protected class. We are an Affirmative Action employer. We encourage individuals with diverse backgrounds to apply and desire priority referrals of protected veterans. If due to a disability you need assistance/and or a reasonable accommodation during the application or recruiting process, please send a request to our Employee Services Center at escmail@fredhutch.org or by calling 206-667-4700.

Research Technician II, Transplant Biology

FH Clinical Research Division
Category: Laboratory Research Sciences
Seattle, WA, US
Job ID: 13791

Overview

Cures Start Here. At Fred Hutchinson Cancer Research Center, home to three Nobel laureates, interdisciplinary teams of world-renowned scientists seek new and innovative ways to prevent, diagnose and treat cancer, HIV/AIDS and other life-threatening diseases. Fred Hutch’s pioneering work in bone marrow transplantation led to the development of immunotherapy, which harnesses the power of the immune system to treat cancer. An independent, nonprofit research institute based in Seattle, Fred Hutch houses the nation’s first and largest cancer prevention research program, as well as the clinical coordinating center of the Women’s Health Initiative and the international headquarters of the HIV Vaccine Trials Network. Careers Start Here.

 

The Hill Lab within the Transplantation Program of the Clinical Research Division is looking for a highly motivated individual to support preclinical and translational research on the use of stem cell transplantation for the treatment of serious blood diseases. The successful candidate will be involved in a variety of cutting edge cellular and molecular techniques to study murine and human immune responses.

Responsibilities

The successful applicant will assist in the day to day running of the laboratory in liaison with senior laboratory members. The candidate will also contribute to multiple projects studying stem cell transplantation, with the ultimate aim to generate testable therapeutic interventions that attenuate graft-versus-host disease and improve graft versus leukemia effects after transplantation. The technician will be closely involved in research projects using both in vivo murine models of transplantation and handling/preparation of clinical samples for analysis.

 

Key duties include:

  • Oversight of flow cytometry sorting, once set up by flow core and laboratory staff.
  • Helping in the maintenance of a large murine colony; schedule and coordinate experiments with other lab members and with collaborators.
  • Prepare and maintain laboratory reagents, stocks, media and maintenance of appropriate levels of laboratory supplies.
  • Preparation and administration of stem cell transplants and therapeutics in mice, close monitoring of animal well-being.

Qualifications

A Bachelor's degree in a scientific discipline with at least two years of professional lab experience in a related field with relevant techniques is required. A Master’s degree in a related field can substitute for two years of professional lab experience. Experience with murine models is also required and flow cytometry experience is preferred.

 

The successful applicant should have an excellent knowledge of immunology, previous research experience including murine handling, genotyping, cell culture, basic flow cytometry and be capable of maintaining detailed laboratory records. Ability to analyze and report primary data would be highly advantageous.

 

Our Commitment to Diversity

We are committed to cultivating a workplace in which diverse perspectives and experiences are welcomed and respected. We are proud to be an Equal Opportunity and VEVRAA Employer. We do not discriminate on the basis of race, color, religion, creed, ancestry, national origin, sex, age, disability, marital or veteran status, sexual orientation, gender identity, political ideology, or membership in any other legally protected class. We are an Affirmative Action employer. We encourage individuals with diverse backgrounds to apply and desire priority referrals of protected veterans. If due to a disability you need assistance/and or a reasonable accommodation during the application or recruiting process, please send a request to our Employee Services Center at escmail@fredhutch.org or by calling 206-667-4700.

Research Technician IV

FH Clinical Research Division
Category: Laboratory Research Sciences
Seattle, WA, US
Job ID: 13839

Overview

 

Cures Start Here. At Fred Hutchinson Cancer Research Center, home to three Nobel laureates, interdisciplinary teams of world-renowned scientists seek new and innovative ways to prevent, diagnose and treat cancer, HIV/AIDS and other life-threatening diseases. Fred Hutch’s pioneering work in bone marrow transplantation led to the development of immunotherapy, which harnesses the power of the immune system to treat cancer. An independent, nonprofit research institute based in Seattle, Fred Hutch houses the nation’s first cancer prevention research program, as well as the clinical coordinating center of the Women’s Health Initiative and the international headquarters of the HIV Vaccine Trials Network. Careers Start Here.


The Paulovich Lab at Fred Hutch is an interdisciplinary team whose mission is to develop and implement tools for protein quantification to enable precision medicine (patient selection and identification of novel therapeutic targets). The lab has a major focus on mass spectrometry, especially multiple reaction monitoring. Our group is highly collaborative, participating in national and international consortia in which teams of scientists, statisticians, and clinicians work together to solve clinical or biological problems to impact human health.


This is a terrific opportunity for a highly motivated, interactive, Protein or Analytical Chemist to join our translational proteomics team to help drive translational projects forward towards clinical applications by performing proteomic experiments and participating in the analysis and interpretation of results.

Responsibilities

  • Process proteomic samples for LC-MS analysis (e.g., protein extraction, fractionation, immuno-depletion, trypsin digestion, alkylation, reduction, etc.)
  • Perform HPLC separations and maintain HPLC instruments
  • Work with antibodies (immunoaffinity purification, immobilization on solid supports, screening hybridomas for mass spectrometry)
  • Generate mass spectrometry (MS)-based proteomics data and maintain MS instruments
  • Contribute to the analysis of proteomic (mass spectrometry) datasets
  • Collaborate effectively with an interdisciplinary team spanning expertise in biology, analytical chemistry, and statistics
  • Collaborate with others to develop new methods and tools that support research objectives
  • Maintain research results files and databases
  • Assist with written progress reports and development of standard operating protocols (SOP)
  • Assist with writing scientific manuscripts for peer-reviewed journals

Qualifications

  • M.S. degree, or B.S. degree and 2+ years post-degree bench experience in Protein Chemistry, Analytical Chemistry, Biochemistry, or related discipline
  • The work is rigorously quantitative, and exquisite attention to detail and the ability to adhere to standard operating protocols (SOP) and maintaining records are critical
  • Excellent written and verbal communication skills
  • Previous experience in a CLIA or clinical lab environment preferred
  • A demonstrated track record of authorship on peer-reviewed journal publications preferred

Our Commitment to Diversity

We are committed to cultivating a workplace in which diverse perspectives and experiences are welcomed and respected. We are proud to be an Equal Opportunity and VEVRAA Employer. We do not discriminate on the basis of race, color, religion, creed, ancestry, national origin, sex, age, disability, marital or veteran status, sexual orientation, gender identity, political ideology, or membership in any other legally protected class. We are an Affirmative Action employer. We encourage individuals with diverse backgrounds to apply and desire priority referrals of protected veterans. If due to a disability you need assistance/and or a reasonable accommodation during the application or recruiting process, please send a request to our Employee Services Center at escmail@fredhutch.org or by calling 206-667-4700.

Staff Scientist, Immunotherapy

FH Clinical Research Division
Category: Laboratory Research Sciences
Seattle, WA, US
Job ID: 10562

Overview

Cures Start Here. At Fred Hutchinson Cancer Research Center, home to three Nobel laureates, interdisciplinary teams of world-renowned scientists seek new and innovative ways to prevent, diagnose and treat cancer, HIV/AIDS and other life-threatening diseases. Fred Hutch’s pioneering work in bone marrow transplantation led to the development of immunotherapy, which harnesses the power of the immune system to treat cancer. An independent, nonprofit research institute based in Seattle, Fred Hutch houses the nation’s first cancer prevention research program, as well as the clinical coordinating center of the Women’s Health Initiative and the international headquarters of the HIV Vaccine Trials Network. Careers Start Here.

 

The Program of Immunology and Clinical Research Division are seeking an experienced Staff Scientist to work in a collaborative environment to help develop and optimize novel TCR gene therapy products for clinical translation, and to support current and future TCR gene therapy clinical trials.

Responsibilities

  • Cell and Molecular Biology: independently perform routine and non-routine experiments that are moderate to complex: Experiments include cell separation using the FACSorter and autoMACs, analyzing cell phenotype and function using techniques including flow cytometry, proliferation assays, PCR, RT-PCR, sequencing, chromium release assays and ELISpots, and viral transduction of human and murine cells.
  • Cell culture and tissue processing: Establishing and maintaining primary cell culture, including human DCs and long-term culture of human T cells
  • Handle projects independently, including literature reviews to assist in determining most suitable methods to be used in research.
  • Contribute to the preparation and presentation of written or oral reports concerning studies and assist in publication of results by proofreading, editing, and contributing ideas.
  • Assist with the management and organization of a fast-paced lab, and perform other duties as assigned by supervisor as necessary.

Qualifications

  • PhD in a related scientific field.
  • Extensive scientific knowledge and acumen: In particular, an in depth understanding of immunology is required, and a solid knowledge of T cell biology is preferred.
  • Extensive experience of at least six years, especially in sterile cell culture techniques and flow analysis, including experience in maintaining long term primary cell cultures, particularly T-cells and/or DCs.
  • Strong analytical and organizational skills: Ability to identify problems and troubleshoot solutions with limited direction in a fast-paced, goal-oriented environment with the ability to analyze data statistically and present it logically.
  • Excellent oral and written communication skills; good interpersonal communication and organizational skills; and flexibility to work in a highly collaborative team environment and interact effectively with different cross-functional groups and potential collaborators on a daily basis.

Our Commitment to Diversity

We are committed to cultivating a workplace in which diverse perspectives and experiences are welcomed and respected. We are proud to be an Equal Opportunity and VEVRAA Employer. We do not discriminate on the basis of race, color, religion, creed, ancestry, national origin, sex, age, disability, marital or veteran status, sexual orientation, gender identity, political ideology, or membership in any other legally protected class. We are an Affirmative Action employer. We encourage individuals with diverse backgrounds to apply and desire priority referrals of protected veterans. If due to a disability you need assistance/and or a reasonable accommodation during the application or recruiting process, please send a request to our Employee Services Center at escmail@fredhutch.org or by calling 206-667-4700.

Staff Scientist, Immunotherapy

FH Clinical Research Division
Category: Post-Doctoral Research Fellows and Associates
Seattle, WA, US
Job ID: 12847

Overview

Cures Start Here. At Fred Hutchinson Cancer Research Center, home to three Nobel laureates, interdisciplinary teams of world-renowned scientists seek new and innovative ways to prevent, diagnose and treat cancer, HIV/AIDS and other life-threatening diseases. Fred Hutch’s pioneering work in bone marrow transplantation led to the development of immunotherapy, which harnesses the power of the immune system to treat cancer. An independent, nonprofit research institute based in Seattle, Fred Hutch houses the nation’s first cancer prevention research program, as well as the clinical coordinating center of the Women’s Health Initiative and the international headquarters of the HIV Vaccine Trials Network. Careers Start Here.

 

The staff scientist will work on independent and collaborative projects developing adoptive T cell immunotherapy for viral driven malignancies within the Program in Immunology and Clinical Research Division at Fred Hutchinson Cancer Research Center in the Chapuis laboratory (https://research.fhcrc.org/chapuis). The successful applicant will employ strategies for cloning T cell receptors (TCRs) and genetic modification of human T cells with TCRs specific for antigens expressed by malignancies. In vitro studies using human T cells and in vivo murine models will be used to develop and test novel T cell therapies. The staff scientist will perform correlative studies to evaluate the transfer, persistence and function of antigen-specific T cells in human clinical trials of adoptive T cell immunotherapy.

 

The Program in Immunology is a leader in the development and clinical application of adoptive immunotherapy using genetically modified T cells and is committed to the advancement of this approach. The staff scientist may also participate in the laboratory evaluation of ongoing clinical trials involving engineering of peripheral blood stem cell grafts for improved allogeneic hematopoietic stem cell transplantation outcomes, and in the development of future immunotherapy strategies. This is a full-time position with excellent benefits.

Responsibilities

  • Study the function of human T cells
  • Molecular bench work with PCR, cloning, and vector design
  • Single cell RNA sequencing
  • Biostatistics and some basic programing skills
  • Cell Culture, cell sorting, flow cytometry, intercellular staining, and transfections
  • Validation through functional and killing assays.
  • Lead a team of 2-3 individuals, combination of Research Technicians and Post-Doctoral Fellows

Qualifications

  • MD and/or a PhD in a biological science with a diverse knowledge of immunology. Must have a strong T/B cell immunology background. 
  • Proficiency in molecular biology, cell culture and cellular immunology technique required
  • Proficiency with murine models required
  • Flow cytometry and cell signaling based assays.
  • Virology knowledge will assist in the aim of this positon
  • Experience in analysis of TCR signaling pathways and in lentiviral modification of T cells will be an advantage
  • Dynamic and driven – engaging and encouraging in team environments; organized to drive multiple projects forward in a team lead role
  • Willingness to write and apply for funding opportunities and abstracts
  • A strong research background

 

To be successful in this position, the staff scientist must be highly motivated and driven to establish a career as a future independent investigator, will need to be able to work independently and collaborate well with others.

Our Commitment to Diversity

We are committed to cultivating a workplace in which diverse perspectives and experiences are welcomed and respected. We are proud to be an Equal Opportunity and VEVRAA Employer. We do not discriminate on the basis of race, color, religion, creed, ancestry, national origin, sex, age, disability, marital or veteran status, sexual orientation, gender identity, political ideology, or membership in any other legally protected class. We are an Affirmative Action employer. We encourage individuals with diverse backgrounds to apply and desire priority referrals of protected veterans. If due to a disability you need assistance/and or a reasonable accommodation during the application or recruiting process, please send a request to our Employee Services Center at escmail@fredhutch.org or by calling 206-667-4700.

Staff Scientist, Protein Chemist/Analytical Chemist

FH Clinical Research Division
Category: Staff Scientist
Seattle, WA, US
Job ID: 13859

Overview

Cures Start Here. At Fred Hutchinson Cancer Research Center, home to three Nobel laureates, interdisciplinary teams of world-renowned scientists seek new and innovative ways to prevent, diagnose and treat cancer, HIV/AIDS and other life-threatening diseases. Fred Hutch’s pioneering work in bone marrow transplantation led to the development of immunotherapy, which harnesses the power of the immune system to treat cancer. An independent, nonprofit research institute based in Seattle, Fred Hutch houses the nation’s first cancer prevention research program, as well as the clinical coordinating center of the Women’s Health Initiative and the international headquarters of the HIV Vaccine Trials Network. Careers Start Here.

 

The Paulovich Lab at Fred Hutch is an interdisciplinary team whose mission is to develop and implement tools for protein quantification to enable precision medicine (patient selection and identification of novel therapeutic targets). The lab has a major focus on mass spectrometry, especially multiple reaction monitoring. Our group is highly collaborative, participating in national and international consortia in which teams of scientists, statisticians, and clinicians work together to solve clinical or biological problems to impact human health.

 

This is a terrific opportunity for a highly motivated, interactive, Protein or Analytical Chemist to join our translational proteomics team to help drive translational projects forward towards clinical applications by performing proteomic experiments and participating in the analysis and interpretation of results.

Responsibilities

  • Process proteomic samples for LC-MS analysis (e.g., protein extraction, fractionation, immuno-depletion, trypsin digestion, alkylation, reduction, etc.)
  • Perform HPLC separations and maintain HPLC instruments
  • Work with antibodies (immunoaffinity purification, immobilization on solid supports, screening hybridomas for mass spectrometry)
  • Generate mass spectrometry (MS)-based proteomics data and maintain MS instruments
  • Contribute to the analysis of proteomic (mass spectrometry) datasets
  • Collaborate effectively with an interdisciplinary team spanning expertise in biology, analytical chemistry, and statistics
  • Collaborate with others to develop new methods and tools that support research objectives
  • Maintain research results files and databases
  • Assist with written progress reports and development of standard operating protocols (SOP)
  • Assist with writing scientific manuscripts for peer-reviewed journals

 

Qualifications

  • Ph.D. degree in Protein Chemistry, Analytical Chemistry, Biochemistry, or related discipline and 3+ years of experience is required
  • The work is rigorously quantitative, and exquisite attention to detail and the ability to adhere to standard operating protocols (SOP) and maintaining records are critical
  • The position includes drafting manuscripts for publication and, thus a demonstrated track record of first author peer-reviewed journal publications, as well as excellent English written communication skills are required.
  • The position includes giving oral presentations at local meetings, on consortium teleconferences, and at national and international meetings; thus excellent English oral communication skills are required.
  • Previous experience in a CLIA or clinical lab environment is a plus

Our Commitment to Diversity

We are committed to cultivating a workplace in which diverse perspectives and experiences are welcomed and respected. We are proud to be an Equal Opportunity and VEVRAA Employer. We do not discriminate on the basis of race, color, religion, creed, ancestry, national origin, sex, age, disability, marital or veteran status, sexual orientation, gender identity, political ideology, or membership in any other legally protected class. We are an Affirmative Action employer. We encourage individuals with diverse backgrounds to apply and desire priority referrals of protected veterans. If due to a disability you need assistance/and or a reasonable accommodation during the application or recruiting process, please send a request to our Employee Services Center at escmail@fredhutch.org or by calling 206-667-4700.

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