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Stories tagged 'transcription factor'

Muscle or neuron? A simple swap can redirect cell fate

Alter just one section of the protein responsible for making a muscle cell a muscle cell — and it makes nerve cells instead

March 19, 2015 | By Dr. Sabrina Richards / Fred Hutch News Service

Scientists at Fred Hutchinson Cancer Research Center discovered that the power to turn precursor stem cells into muscle cells or neurons lies in one small section of the gene-orchestrating proteins. When they replaced this segment of the muscle-specific protein, called MyoD, with the corresponding segment from the neuronal protein, MyoD transformed into a protein that pushed cells down the path of neuronal development. The team’s findings, published March 19 in Cell Reports, could have wider implications for researchers looking to hobble the genetic programs cancer cells coopt in order to grow unrestrainedly.

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Galloway, Paddison, Eisenman land Provocative Questions grants

Fred Hutch investigators among first in nation to receive new National Cancer Institute awards to pursue novel, creative directions in cancer research

Oct. 29, 2012 | By Rachel Tompa

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Tapscott Lab's Geng among Weintraub winners

Molecular and cell biologist Linda Geng is one of 13 recipients nationwide of the Center's 2012 Harold M. Weintraub Graduate Student Award

March 12, 2012

Dr. Linda Geng, formerly of the Fred Hutchinson Cancer Research Center's Tapscott Lab, is among 13 graduate students from institutions throughout North America chosen to receive the Center's 2012 Harold M. Weintraub Graduate Student Award.

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