A precise new technique reveals that our cells’ engines, mitochondria, unexpectedly shrug off DNA damage from toxic chemicals
Sept. 1, 2016
| By Sabrina Richards / Fred Hutch News Service
Surprisingly, instead of falling prey to DNA damage that would cause rampant genetic errors, mitochondria are somehow able to outrun this damage and keep their DNA error-free, scientists at Fred Hutch have shown.
Study in fruit flies identifies a mutation in mitochondria — the energy factories of our cells — that harms males but not females
Aug. 2, 2016
| By Rachel Tompa / Fred Hutch News Service
For the first time, evolutionary biologists at Fred Hutch have identified a "Mother's Curse" mutation - a genetic change harmful to males but not females - in animals. The mutation renders male fruit flies sterile but leaves female flies untouched.
Hutchinson Center finding sheds new light on genetic mutations in cancer development; may open new avenues for cancer therapy, early detection and monitoring treatment response
June 11, 2012
| By Kristen Woodward
Dr. Jason Bielas and colleagues at the Fred Hutchinson Cancer Research Center have made a surprising discovery that challenges previously held beliefs about the role of mutations in cancer development. For the first time, they found that the number of new mitochondrial DNA mutations is significantly lower in cancers than in normal cells.
Gottschling Lab discovers defect to a key cellular process that goes off course as cells grow older
Aug. 17, 2009
| by Gordon Todd
Following his 2003 landmark discovery in yeast that shed light on why age is the greatest cancer risk factor in humans, Dr. Dan Gottschling and colleagues at the Fred Hutchinson Cancer Research Center have zeroed in on a key underlying cellular process that goes awry with age. Their findings, “Mitochondrial Dysfunction Leads to Nuclear Genome Instability via an Iron-Sulfur Cluster Defect,” appeared in the June 26 issue of Cell.