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Stories tagged 'MGMT gene'

Transplanted stem cell 'shield' helps brain cancer patients

Hans-Peter Kiem study is first to show patients' own gene-modified blood stem cells can protect bone marrow from chemotherapy toxicity

May 14, 2012 | By Dean Forbes

For the first time, Fred Hutchinson Cancer Research Center scientists have transplanted brain cancer patients' own gene-modified blood stem cells in order to protect their bone marrow against the toxic side effects of chemotherapy. Initial results of the ongoing, small clinical trial of three patients with glioblastoma showed that two patients survived longer than predicted if they had not been given the transplants, and a third patient remains alive with no disease progression almost three years after treatment.

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Modified marrow cells may resist chemotherapy’s toxic effects

Hans-Peter Kiem and colleagues find chemo-resistant genes may enable safer, more effective treatment for brain cancer patients

May 23, 2011 | By Dean Forbes

Chemotherapy kills cancer cells, but its toxic effects on normal cells such as bone marrow and blood cells limits its use. Fred Hutchinson Cancer Research Center researchers have found a possible approach to reduce this toxicity: modify the bone marrow cells with a gene that makes them resistant to chemotherapy.

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