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Stories tagged 'estrogen'

Women's Health Initiative's landmark hormone replacement research 10 years after

Seminal study found significantly higher risk of heart disease, stroke, breast cancer from combined hormone replacement therapy; as a result, 15,000-20,000 fewer breast cancer cases each year

June 25, 2012 | By Rachel Tompa

July marks the 10th anniversary of the WHI's first publication describing the risks of combination hormone therapy. That paper, published in the Journal of the American Medical Association, has singularly changed the face of women's medicine around the world. Researchers estimate that because of the decrease in hormone therapy use following the WHI publication, there have been 15,000-20,000 fewer cases of breast cancer each year in the United States.

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Postmenopausal estrogen use brings both benefits, risks

Longer-term Women’s Health Initiative follow-up of estrogen therapy users finds reduced risk of breast cancer, decreased heart disease in younger women

April 11, 2011

Strokes and other health problems linked with estrogen pills appear to fade when women quit taking them after menopause, a long-term follow-up study from the landmark Women’s Health Initiative has found. The findings also confirm that concerns about breast cancer and heart attacks are largely unfounded for those who take the hormone for a short period of time to relieve hot flashes and other menopause symptoms.

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Obesity, inactivity may increase risk of breast cancers

Study finds women with highest body fat face higher risk of ’triple-negative’ and estrogen receptor-positive breast cancers; risk drops with fitness gains

March 14, 2011

Women’s Health Initiative researchers found a relationship between obesity, physical activity and triple-negative breast cancer, a subtype of breast cancer characterized by a lack of estrogen, progesterone and HER2 expression. Triple-negative breast cancers account for about 10 percent to 20 percent of all breast cancers and are associated with an extremely poor prognosis due to a lack of targeted drug therapies.

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