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Hutch News

Stories tagged 'chemotherapy resistance'

It's more than hair

A cancer researcher with cancer writes about family, identity and being outed by her own hair

June 3, 2015 | By Dr. Kiran Dhillon / For Fred Hutch News Service

A breast and ovarian cancer researcher with breast cancer writes about identity, family and being outed by her own hair. Dr. Kiran Dhillon chronicles her experience in this occasional series.

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Cancer chemotherapy resistance: Hutchinson Center team discovers new mechanism

Noncancerous fibroblasts when exposed to chemotherapy sustain DNA damage that drives the production of an array of factors that stimulate solid tumor cancer growth

Aug. 6, 2012 | By Kristen Woodward

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Potential breakthrough in pancreatic cancer treatment

Sunil Hingorani-led study breaks unique tumor defense, extends survival in mice by 70 percent; initial human studies under way

March 19, 2012 | By Dean Forbes

Pancreatic cancer tumors spread quickly and are notoriously resistant to treatment, making them among the deadliest of malignancies. Their resistance to chemotherapy stems in part from a unique biological barrier the tumor builds around itself. Now scientists at the Fred Hutchinson Cancer Research Center have found a way to break through that defense, and their research represents a potential breakthrough in the treatment of pancreatic cancer.

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Kuni Scholar award paves way for breakthrough research

Medical scientist Maria Corinna Palanca-Wessels, working to defeat ovarian cancer, is among three Pacific Northwest scientists in the inaugural class of Kuni Scholars

July 11, 2011 | By Kristen Woodward

Dr. Maria Corinna Palanca-Wessels of the Fred Hutchinson Cancer Research Center is one step closer to her goal of making ovarian tumors more susceptible to chemotherapy thanks to a two-year, $200,000 award from the Wayne D. Kuni and Joan E. Kuni Foundation of Vancouver, Wash., and the Kuni family (through the 3725 Fund of the Oregon Community Foundation).

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Modified marrow cells may resist chemotherapy’s toxic effects

Hans-Peter Kiem and colleagues find chemo-resistant genes may enable safer, more effective treatment for brain cancer patients

May 23, 2011 | By Dean Forbes

Chemotherapy kills cancer cells, but its toxic effects on normal cells such as bone marrow and blood cells limits its use. Fred Hutchinson Cancer Research Center researchers have found a possible approach to reduce this toxicity: modify the bone marrow cells with a gene that makes them resistant to chemotherapy.

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Why pancreatic-cancer drugs can fail

Sunil Hingorani and an international team of investigators shed light on reasons patients are often resistant to gemcitabine treatment

May 25, 2009

An international team of investigators, led by Cancer Research UK scientists and including the Fred Hutchinson Cancer Research Center's Dr. Sunil Hingorani, have discovered a mechanism that may explain why pancreas-cancer patients are often resistant to a common chemotherapy treatment called gemcitabine.

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