Atlas of immune-evading HIV mutations could inform design of new treatments, vaccines
Jan. 29, 2019
| By Sabrina Richards / Fred Hutch News Service
Fred Hutch scientists have constructed an atlas of mutations that HIV uses to escape broadly neutralizing antibodies, potent immune molecules that form our body’s first line of defense against the virus. The information could help guide researchers who are testing these antibodies’ potential to prevent or treat HIV infection, as well as those working to develop more effective preventive vaccines.
Laboratory manipulation of the AIDS-causing virus reveals evolutionary ‘dead-ends’
June 1, 2017
| By Rachel Tompa / Fred Hutch News Service
Fred Hutch researchers have created a library containing millions of mutant HIV viruses. Some of these mutants are very good at infecting human cells, no different from their “natural” viral ancestor. Some of them are worse. Together, they can teach researchers something important about HIV in humans.
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