Sue Biggins discusses her breakthrough research on kinetochores and how they control mitosis
March 26, 2012
Biggins describes her breakthrough research in the March 19 online edition of the Journal of Cell Biology. In the profile, she discusses what her Basic Sciences Division lab at the Fred Hutchinson Cancer Research Center is discovering about kinetochores and how they control mitosis, the cell division process.
Sunil Hingorani-led study breaks unique tumor defense, extends survival in mice by 70 percent; initial human studies under way
March 19, 2012
| By Dean Forbes
Pancreatic cancer tumors spread quickly and are notoriously resistant to treatment, making them among the deadliest of malignancies. Their resistance to chemotherapy stems in part from a unique biological barrier the tumor builds around itself. Now scientists at the Fred Hutchinson Cancer Research Center have found a way to break through that defense, and their research represents a potential breakthrough in the treatment of pancreatic cancer.
Geneticist Bruce Edgar, colleagues reveal endocycle underpinnings, with implications for agriculture, medicine
Oct. 31, 2011
| By Kristen Woodward
An international team of researchers led by investigators in the U.S. and Germany has shed light on the inner workings of the endocycle, a common cell cycle that fuels growth in plants, animals and some human tissues and is responsible for generating up to half of the Earth's biomass. This discovery, led by Fred Hutchinson Cancer Research Center geneticist Dr. Bruce Edgar and reported Oct. 30 in Nature, leads to a new understanding of how cells grow and how rates of cell growth might be increased or decreased, which has important implications in both agriculture and medicine.