Scientists discover a protein that keeps cellular nuclei from shriveling, a hallmark of old age and the premature-aging disease progeria
March 5, 2015
| By Rachel Tompa / Fred Hutch News Service
Scientists at Fred Hutchinson Cancer Research Center have found a protein that helps shape the nucleus, a special compartment within cells that houses and controls genetic information. When cells are missing that protein, known as Wash, nuclei lose their classic plump shape and become wrinkled and puckered. Nuclei pucker in the natural aging process and in certain diseases including progeria, a rare and fatal genetic disorder that dramatically speeds up aging. Whether Wash plays a role in progeria or aging is still unclear, but these findings are an intriguing hint that it might, said Dr. Susan Parkhurst, a biologist at Fred Hutch.
Fred Hutch scientists find long-lived molecules influence aging
Sept. 22, 2014
| By Dr. Rachel Tompa / Fred Hutch News Service
As we age, many parts of our bodies break down, never to be repaired. It turns out that the same is true of our cells. New research findings from Fred Hutchinson Cancer Research Center scientists point to microscopic systems that degenerate over time, triggering cellular aging that may in turn spur human aging and age-related diseases.
Basic Sciences Division's Carissa Perez Olsen is among first 10 recipients of new award designed to leapfrog outstanding junior investigators directly into faculty positions; two affiliate researchers also among recipients
Oct. 3, 2011
| By Kristen Woodward
Dr. Carissa Perez Olsen, a Weintraub Scholar in the Fred Hutchinson Cancer Research Center's Basic Sciences Division, is the recipient of the National Institutes of Health Director's Early Independence Award. She is among the first group of 10 junior U.S. investigators to receive the honor—designed to carry creative, confident young scientists directly into full-fledged research careers. Olsen will receive $1.25 million over five years for her research into the mechanisms of cancer, aging-related diseases and natural aging.