Viral Infections

Vaccine and Infectious Disease Division

Viral Infections

Prevention strategies and therapeutic options for many viruses are currently inadequate for the successful reduction of disease prevalence, especially in resource-poor settings. VIDD is home to one of the world’s largest vaccine programs that includes vaccine development and clinical trial studies. Several VIDD disciplines, such as virology, epidemiology and statistics, work in concert with the common goal of curbing viral infection.

Faculty

Alphabetical Listing:

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Clinical trial data management, Logistics, operations and study facilitation, Scientific communications, Host-pathogen interactions High-dimensional data analysis
Senior Staff Scientist, Jerome Lab, Vaccine and Infectious Disease Division
Research interests include targeting latent viral genomes for mutagenesis and disruption of viral pathogenesis and infection using engineered homing endonucleases.
Characterizes virus diversity, evolution, circulation patterns. Identifies epidemiological patterns from sequence data and develops methods to predict evolutionalry growth or decay across strains.
Phone: (206) 667-6372
Co-infections impact clinical, virological, and immunologic outcomes in HIV. I work on understanding how we can better treat patients to prevent HIV and HIV-associated complications, including focus on HIV persistence and HIV-associated malignancies.
Phone: (206) 667-4628
Fax: (206) 667-7711
Head, Infectious Disease Sciences Program, Vaccine and Infectious Disease Division
Professor, Medicine, University of Washington
Attending Physician and Head, SCCA Infectious Disease Consulting Service, Seattle Cancer Care Alliance
Infections in the immunocompromised host, especially diagnosis, prevention and treatment of CMV, VZV, BK virus, adenovirus, and respiratory virus infections. Research includes understanding the genetic basis of infeciton complications, genome and gene expression studies.
Phone: (206) 667-6706
Fax: (206) 667-4411
Affiliate Professor, Biostatistics, University of Washington
Research focus includes the development of statistical methods for analysis of survival and longitudinal data from clinical trials and epidemiological studies.
Phone: (206) 667-7051
Fax: (206) 667-4378
Characterization of immunological “signature” associated with development of cross-neutralizing antibody responses in HIV-infected individuals.
President and Director Emeritus, Fred Hutchinson Cancer Research Center
Professor, Medicine and Laboratory Medicine, University of Washington
Research focus is HIV and herpesvirus vaccine development, herpes simplex virus type 2 (HSV-2) pathogenesis and the host immune response. Immunotherapeutic approaches to viral infections and cancer
Phone: (206) 667-6770
Fax: (206) 667-7711
Research Associate Professor, Laboratory Medicine, University of Washington
Graduate Faculty, Laboratory Medicine, University of Washington
Director, Center for AIDS Research Immunology Core, University of Washington
Characterizing T cells induced by candidate vaccines using flow cytometry. Developing new assays to evaluate vaccine efficacy with HIV Vaccine Trials Network. Studies include examining T cell function at the single-cell level using advanced flow cytometric techniques; examples include T cell responses to vaccination and to viral infections such as CMV, EBV, HIV, and hepatitis B.
Research focus include clinical trial design; clinical trials data management in international settings, group and cluster randomized; analysis of sexual risk; and mediator analysis
Phone: (206) 667-5661
Fax: (206) 667-4378
Affiliate Assistant Professor, Biostatistics, University of Washington
Statistical and computational methods for bioinformatics applications, statistical modeling for genome sequence analysis and statistical modeling frameworks. The interface between computer science, statistics, and molecular biologyand such as development of new informatics methods in genomics and post-genomics
Phone: (206) 667-4086
Fax: (206) 667-4378
Current studies include development of methods for T-cell based sieve analysis, quantification of vaccine induced T cell responses, systems biology of influenza and time-dependent correlates analysis of HIV efficacy trial.
Immune monitoring and correlative science analyses for early clinical trials in the area of cancer immunotherapy.
Associate Director for Laboratory Science, HIV Vaccine Trials Network
Associate Professor, Department of Global Health, University of Washington
Graduate Faculty, Global Health, University of Washington
Elucidating cellular mechanisms for control of HIV replication, Assessing cellular immune responses in HIV vaccine recipients, Teaching and Mentoring Interests, HIV immunology for experts and the public
Principal Investigator, Statistical Data Management Center, HIV Vaccine Trials Network
Research Professor, Biostatistics, University of Washington
Graduate Faculty, Biostatistics, University of Washington
Research focus includes vaccine clinical trials, the design and analysis of Phase I/II trials, for evaluating vaccine effects on immune responses; the design and analysis of Phase 2b/III trials, for evaluating vaccine efficacy, immune correlates, sieve analysis, and post-infection vaccine effects; general biostatistical methods research, such as survival analysis, causal inference, and evaluation of surrogate endpoints
Phone: (206) 667-7299
Fax: (206) 667-4812
Affiliate Associate Professor, Statistics, University of Washington
Developing methods and tools for high throughput, high dimensional experiments with applications in vaccine research and immunology; flow cytometry, peptide microarrays, next generation sequencing; Bayesian inference and computation and statistical computing
Phone: (206) 667-4076
Fax: (206) 667-4378
Roles of regulatory T cells in modulating anti-viral immunity, understanding the host immune response in anti-viral immunity and vaccine development
Clinical Trials Physician /Protocol Team Leader, HIV Vaccine Trials Network (HVTN)
Immunology and vaccine design for development of vaccines, especially HIV-1 vaccine
Principal Staff Scientist, Vaccine and Infectious Disease Division
Assistant Clinical Professor, Biostatistics, Yale University, School of Public Health
Design, conduct, monitoring, and analysis of multicenter randomized clinical trials and comparative effectiveness studies, measuring and improving the effectiveness of informed consent in clinical research; improving the quality and efficiency of clinical trial data management; clinical research trials for the prevention or treatment of HIV / AIDS and vaccine clinical trials
Phone: (206) 667-6761
Fax: (206) 667-7767
Attending Physician, SCCA Infectious Disease Service , Seattle Cancer Care Alliance
Acting Assistant Professor, University of Washington
Clinical and translational investigations relating to infections in immunocompromised hosts, with a focus on disease associations, risk stratification, and diagnostic strategies for viral infections in transplant recipients
Phone: (206) 667-6504
Fax: (206) 667-4411
Research Professor, Obstetrics & Gynecology, University of Washington
Adjunct Research Professor, Medicine, University of Washington
Combines laboratory studies and systems biology tools to understand the interplay between pathogens, the mucosa, and medical interventions
Phone: (206) 667-6848
Fax: (206) 667-7767
Associate Director for Laboratory Operations, HIV Vaccine Trials Network (HVTN)
Immunologic endpoint determination for experimental vaccines (HIV, pneumococcus, malaria, TB, flu) and Logistics, operations, quality assurance, and assay validation for immunologic evaluation of vaccines in the clinical trial setting
Research focus includes statistical methods for bioassays (e.g., flow cytometry, sequencing); dynamic modeling of biological systems (e.g., multi-type cell populations, B-cell repertoire); nonparametric methods for supervised and unsupervised learning; stochastic processes (e.g., branching processes); algorithms for scalable data analysis.
Phone: (206) 667-2809
Fax: (206) 667-4378
Professor, Laboratory Medicine, University of Washington
Head, Virology Division, University of Washington
Director, Molecular Virology Laboratory, Laboratory Medicine, University of Washington
Clinically important persistent and latent viral infections; curative therapies for latent viral infections ;diagnosis of disease caused by herpesviruses, enterovirus, JC and BK viruses, parvovirus B19, and hepatitis viruses
Phone: (206) 667-6793
Fax: (206) 667-6179
Research focus includes the study the barrier and immune mechanisms that contribute to protection after circumcision, vaccine or passive immunizations at mucosal sites of encounter with HIV
Phone: (206) 667-2221
Associate Professor, Global Health, University of Washington
Graduate Faculty, Global Health, University of Washington
Regulatory T cells in modulation of anti-viral immunity; HIV immunology; and immunogenetics and virus infection
Research Associate Professor, Laboratory Medicine, University of Washington
Graduate Faculty, Laboratory Medicine, University of Washington
Statistical support to clinical research on HSV1 and HSV2 and other herpesvirus infections; Clinical association between herpes and HIV; statistical methods work in areas such as misclassification in time-to-event outcomes, laboratory assay validation, and methods for quantifying and examining risk factors for viral shedding
Phone: (206) 520-4316
Fax: (206) 520-4371
Research interests include analysis of immune response to vaccine candidates, study design for pilot studies, statistical methods for biological assays, and infectious disease models.
Phone: (206) 667-2310
Senior Vice President and Director, Vaccine and Infectious Disease Division
Professor of Medicine, University of Washington
Adjunct Professor, Pathobiology, Global Health, and Laboratory Medicine, University of Washington
Research centers on developing an HIV vaccine and investigating the complex relationship between HIV and the immune system and the influence of antiretroviral therapy.
Assistant Member, Immunology and Vaccine Development, Vaccine and Infectious Disease Division
Research interests include HIV-1 immunogen design, the development of broadly neutralizing antibodies for HIV-1 infection and antigen-B cell interactions.
Structure-based vaccine design has proven possible for certain pathogens and my research aims at applying this paradigm to HIV-1 vaccines
Phone: (206) 667-6585
Medical Director of Infection Prevention, Seattle Cancer Care Alliance
Associate Professor, Department of Medicine, University of Washington
Adjunct Associate Professor, Epidemiology, University of Washington
Attending Physician, SCCA Infectious Disease Consulting Service, Seattle Cancer Care Alliance
Natural Killer Cell Receptor Diversity and CMV in Hematopoietic Cell Transplantation; Viral infections after Hematopoietic Stem Cell Transplantation; Epidemiology of invasive Fungal infections in Cord Blood Transplant Recipients and Clinical trials of the prevention of post-transplant infection
Phone: (206) 667-7538
Fax: (206) 667-4411
Affiliate Associate Professor, Department of Global Health, University of Washington
Faculty Member, Interdisciplinary Program in Pathobiology, University of Washington
Faculty Member, Molecular & Cellular Biology Program, Fred Hutch & University of Washington
Study T cell fate and function in healthy and inflamed tissues and following infection with HIV and manipulate these responses for therapeutic purposes
Phone: (206) 667-2216
Fax: (206) 667-2209
Research Professor, Biostatistics, University of Washington
Adjunct Research Professor, Global Health, University of Washington
Graduate Faculty, Biostatistics and Global Health, University of Washington
Statistical methods for analyzing infectious disease data; developing methods to analyze infectious disease data and developing methods to analyze data with missing values
Phone: (206) 667-7788
Fax: (206) 667-4378
Associate Member, Clinical Research Division
Associate Professor, Department of Medicine, University of Washington
Attending Physician, SCCA Infectious Consulting Service, Seattle Cancer Care Alliance
Interest in describing the quantitative and dynamical features of human pathogens and immune responses. Most of work to-date is on the pathogenesis of HSV-2 infection but also interested in applying models to optimize viral eradication startegies, and to use models to capture kinetic features of the human microbiome.
Clinical Associate Professor, Surgery, University of Washington
Staff Physician, AIDS Clinical Trials Unit, University of Washington
Research focus includes HIV clinical trial design and conduct; complications of antiretroviral therapy and HIV-associated malignancies
Senior Staff Scientist, Corey Lab, Vaccine and Infectious Disease Division
Research focus includes the analysis of humoral immune response to HSV-2 and its vaccine candidates and understanding the role of tissue B cells in HSV-2 infection
Phone: (206) 667-5503
Fax: (206) 667-4411
Affiliate Professor, Department of Global Health, University of Washington
Research is focused on the development of a safe and effective vaccine to combat the spread of HIV and to investigate how HIV infection leads to AIDS. Two major areas of research is to better understand how neutralizing antibodies against HIV are developed during natural HIV-infection,and engineer immunogens that will elicit broadly neutralizing antibody responses against HIV.
Phone: (206) 667-2995
Fax: (206) 667-7767
Senior Staff Scientist, Jerome Lab, Vaccine and Infectious Disease Division
Research focus includes development of DNA editing enzymes that target the genomes of viruses that undergo latent infections and viral vectors for gene delivery to sites of latent viral infection
Structural molecular immunology and vaccinology: using biophysical approaches to study proteins and interactions mediating or modulating adaptive and innate immune responses
Phone: (206) 667-5587
Fax: (206) 667-5939
Epidemiologic studies of infectious disease transmission, vaccine studies and the development of novel statistical methods and designs for studies of infectious disease transmission. Efficacy and effectiveness assessments of control and prevention strategies for infectious diseases of import to global health, including influenza, cholera, dengue, and tuberculosis
Assistant Member, Immunology and Vaccine Development, Vaccine and Infectious Disease Division
Affiliate Assistant Professor, Department of Global Health, University of Washington
Affiliate Assistant Professor, Department of Immunology, University of Washington
Faculty Member, Molecular & Cellular Biology Program, University of Washington
Research interests involve mechanisms driving the differentiation of B cells following vaccination and infection, understanding how differences in the pre-immune repertoire influences immunity and vaccine Development
Attending Physician, Seattle Children’s Hospital
Translational research on viral and host risk factors for disease severity of respiratory viral infections in immunocompromised hosts.
Phone: (206) 667-7329
Fax: (206) 667-4411
Professor, Medicine, Laboratory Medicine, and Epidemiology, University of Washington
Graduate Faculty, Medicine, Laboratory Medicine, and Epidemiology, University of Washington
Head, Division of Allergy & Infectious Diseases, University of Washington
Attending Physician, SCCA Infectious Disease Consulting Service, Seattle Cancer Care Alliance
Epidemiology, natural history, therapy, and prevention of HSV and other herpesvirus infections; interactions between HSV and HIV Vaccines and clinical trials
Phone: (206) 520-4340