Vaccine Development

Vaccine and Infectious Disease Division

Vaccine Development

Chronic infections present a large global health threat and therefore prevention is currently a major focus for reducing disease prevalence. The prevention strategies of vaccination have shown some highly promising results on diseases such as HIV and HSV-1, and the advancement and evolution of vaccine development in VIDD involves an ambitious team of scientists. Basic scientists, computer and animal modelers, statisticians, epidemiologists and clinicians work together throughout this rigorous process, from idea conception to clinical trial design and finally to vaccine production.

Faculty

Alphabetical Listing:

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Senior Staff Scientist, McElrath Lab, Vaccine and Infectious Disease Division
Research interests include early innate immune responses to HIV vaccines on subsequent adaptive immune responses and systems biology analyses of how immune responses are shaped
Clinical Assistant Professor, Global Health, University of Washington
Research interests include sexual risk taking, victimization and alcohol/drug abuse among African-American women, HIV prevention for African American and African-born populations and health disparities.
Phone: (206) 667-2074
Fax: (206) 667-6366
Clinical trial data management, Logistics, operations and study facilitation, Scientific communications, Host-pathogen interactions High-dimensional data analysis
Characterizes virus diversity, evolution, circulation patterns. Identifies epidemiological patterns from sequence data and develops methods to predict evolutionalry growth or decay across strains.
Phone: (206) 667-6372
Head, Infectious Disease Sciences Program, Vaccine and Infectious Disease Division
Professor, Medicine, University of Washington
Attending Physician and Head, SCCA Infectious Disease Consulting Service, Seattle Cancer Care Alliance
Infections in the immunocompromised host, especially diagnosis, prevention and treatment of CMV, VZV, BK virus, adenovirus, and respiratory virus infections. Research includes understanding the genetic basis of infeciton complications, genome and gene expression studies.
Phone: (206) 667-6706
Fax: (206) 667-4411
Characterization of immunological “signature” associated with development of cross-neutralizing antibody responses in HIV-infected individuals.
President and Director Emeritus, Fred Hutchinson Cancer Research Center
Professor, Medicine and Laboratory Medicine, University of Washington
Research focus is HIV and herpesvirus vaccine development, herpes simplex virus type 2 (HSV-2) pathogenesis and the host immune response. Immunotherapeutic approaches to viral infections and cancer
Phone: (206) 667-6770
Fax: (206) 667-7711
Correlates analysis, sieve analysis and antigenic mapping focusing on HIV-1 vaccines and immunology
Phone: (206) 667-2569
Fax: (206) 667-4378
Research Associate Professor, Laboratory Medicine, University of Washington
Graduate Faculty, Laboratory Medicine, University of Washington
Director, Center for AIDS Research Immunology Core, University of Washington
Characterizing T cells induced by candidate vaccines using flow cytometry. Developing new assays to evaluate vaccine efficacy with HIV Vaccine Trials Network. Studies include examining T cell function at the single-cell level using advanced flow cytometric techniques; examples include T cell responses to vaccination and to viral infections such as CMV, EBV, HIV, and hepatitis B.
Director for Scientific Affairs, HIV Vaccine Trials Network
Affiliate Professor, Epidemiology and Global Health, University of Washington
The conduct of HIV vaccine trials, novel vaccine strategies, the conduct of clinical trials in resource-poor settings, and factors that help prevent sexual transmission of HIV.
Phone: (206) 667-7938
Fax: (206) 667-7711
Affiliate Assistant Professor, Biostatistics, University of Washington
Statistical and computational methods for bioinformatics applications, statistical modeling for genome sequence analysis and statistical modeling frameworks. The interface between computer science, statistics, and molecular biologyand such as development of new informatics methods in genomics and post-genomics
Phone: (206) 667-4086
Fax: (206) 667-4378
Computational and statistical methods development for high-throughput, high-content biological data. Modeling and integration of data from high throughput assays for biomarker discovery, clinical outcome prediction and disease classification.
Phone: (206) 667-3116
Fax: (206) 667-4378
Current studies include development of methods for T-cell based sieve analysis, quantification of vaccine induced T cell responses, systems biology of influenza and time-dependent correlates analysis of HIV efficacy trial.
Immune monitoring and correlative science analyses for early clinical trials in the area of cancer immunotherapy.
Affiliate Associate Professor, Biostatistics, University of Washington
Principal Investigator, Fong Group
Statistical problems in biological assays, Biological sequence analysis, Stochastic optimization
Phone: (206) 667-1093
Fax: (206) 667-4378
Associate Director for Laboratory Science, HIV Vaccine Trials Network
Associate Professor, Department of Global Health, University of Washington
Graduate Faculty, Global Health, University of Washington
Elucidating cellular mechanisms for control of HIV replication, Assessing cellular immune responses in HIV vaccine recipients, Teaching and Mentoring Interests, HIV immunology for experts and the public
Principal Investigator, Statistical Data Management Center, HIV Vaccine Trials Network
Research Professor, Biostatistics, University of Washington
Graduate Faculty, Biostatistics, University of Washington
Research focus includes vaccine clinical trials, the design and analysis of Phase I/II trials, for evaluating vaccine effects on immune responses; the design and analysis of Phase 2b/III trials, for evaluating vaccine efficacy, immune correlates, sieve analysis, and post-infection vaccine effects; general biostatistical methods research, such as survival analysis, causal inference, and evaluation of surrogate endpoints
Phone: (206) 667-7299
Fax: (206) 667-4812
Affiliate Associate Professor, Statistics, University of Washington
Developing methods and tools for high throughput, high dimensional experiments with applications in vaccine research and immunology; flow cytometry, peptide microarrays, next generation sequencing; Bayesian inference and computation and statistical computing
Phone: (206) 667-4076
Fax: (206) 667-4378
Roles of regulatory T cells in modulating anti-viral immunity, understanding the host immune response in anti-viral immunity and vaccine development
Clinical Trials Physician /Protocol Team Leader, HIV Vaccine Trials Network (HVTN)
Immunology and vaccine design for development of vaccines, especially HIV-1 vaccine
Principal Staff Scientist, Vaccine and Infectious Disease Division
Assistant Clinical Professor, Biostatistics, Yale University, School of Public Health
Design, conduct, monitoring, and analysis of multicenter randomized clinical trials and comparative effectiveness studies, measuring and improving the effectiveness of informed consent in clinical research; improving the quality and efficiency of clinical trial data management; clinical research trials for the prevention or treatment of HIV / AIDS and vaccine clinical trials
Phone: (206) 667-6761
Fax: (206) 667-7767
Research interests include the interplay between T follicular helper cells and B cells during immune responses, roles of the innate immune system in vaccination and HIV-1 vaccine development.
Phone: (206) 667-2223
Fax: (206) 667-2209
Affiliate Associate Professor, Biostatistics, University of Washington
Statistical methods in biomarker evaluation for disease screening, surrogate endpoint identification, and treatment selection; genome-wide association studies and causal inference
Phone: (206) 667-4198
Fax: (206) 667-4378
Associate Director for Laboratory Operations, HIV Vaccine Trials Network (HVTN)
Immunologic endpoint determination for experimental vaccines (HIV, pneumococcus, malaria, TB, flu) and Logistics, operations, quality assurance, and assay validation for immunologic evaluation of vaccines in the clinical trial setting
Research focus includes statistical methods for bioassays (e.g., flow cytometry, sequencing); dynamic modeling of biological systems (e.g., multi-type cell populations, B-cell repertoire); nonparametric methods for supervised and unsupervised learning; stochastic processes (e.g., branching processes); algorithms for scalable data analysis.
Phone: (206) 667-2809
Fax: (206) 667-4378
Affiliate Associate Professor, Biostatistics, University of Washington
Graduate Faculty, Biostatistics, University of Washington
Clinical trials methodology; Vaccine evaluation; biomarker that predict an individual’s response to a given treatment and statistical analyses of vaccine trial data
Phone: (206) 667-6353
Fax: (206) 667-4378
Design and analysis of vaccine efficacy trials, genotype-specific vaccine efficacy-based sieve analysis,immune correlates of vaccine protection, analysis of vaccine-induced immune response durability and survival analysis
Phone: (206) 667-5568
Director of Clinical Development, HIV Vaccine Trials Network (HVTN)
Clinical Trials Physician/Protocol Team Leader, HIV Vaccine Trials Network (HVTN)
HIV vaccine development and trial design, combination HIV prevention, mucosal immunology and mucosal sampling design in HIV prevention trials, the intersection of oncology and infectious disease, comparative effectiveness, decision analysis and health-related quality of life
Principal Staff Scientist, Vaccine and Infectious Disease Division
Clinical Associate Professor, Global Health, University of Washington
HIV and tuberculosis (Tb) vaccine research and development, human challenge experiments, microbiome modulation of immunity, immune activation—polymicrobial infections, combination HIV prevention, malaria clinical trials/vaccines and molecular epidemiology
Research interests involved developing and implementing clinical trials for HIV vaccines, mucosal sampling in HIV Vaccine trials and cultural/community challenges in implementing Vaccine Trials in Africa
Research interests include analysis of immune response to vaccine candidates, study design for pilot studies, statistical methods for biological assays, and infectious disease models.
Phone: (206) 667-2310
Senior Vice President and Director, Vaccine and Infectious Disease Division
Professor of Medicine, University of Washington
Adjunct Professor, Pathobiology, Global Health, and Laboratory Medicine, University of Washington
Research centers on developing an HIV vaccine and investigating the complex relationship between HIV and the immune system and the influence of antiretroviral therapy.
Assistant Member, Immunology and Vaccine Development, Vaccine and Infectious Disease Division
Research interests include HIV-1 immunogen design, the development of broadly neutralizing antibodies for HIV-1 infection and antigen-B cell interactions.
Senior Staff Scientist, Public Health Sciences Division
Research focus includes vaccine clinical trials, SNP analysis, novel statistical methodology, nonparametric methods
Phone: (206) 667-7077
Fax: (206) 667-4378
Structure-based vaccine design has proven possible for certain pathogens and my research aims at applying this paradigm to HIV-1 vaccines
Phone: (206) 667-6585
Affiliate Associate Professor, Department of Global Health, University of Washington
Faculty Member, Interdisciplinary Program in Pathobiology, University of Washington
Faculty Member, Molecular & Cellular Biology Program, Fred Hutch & University of Washington
Study T cell fate and function in healthy and inflamed tissues and following infection with HIV and manipulate these responses for therapeutic purposes
Phone: (206) 667-2216
Fax: (206) 667-2209
Associate Member, Clinical Research Division
Associate Professor, Department of Medicine, University of Washington
Attending Physician, SCCA Infectious Consulting Service, Seattle Cancer Care Alliance
Interest in describing the quantitative and dynamical features of human pathogens and immune responses. Most of work to-date is on the pathogenesis of HSV-2 infection but also interested in applying models to optimize viral eradication startegies, and to use models to capture kinetic features of the human microbiome.
Senior Staff Scientist, Corey Lab, Vaccine and Infectious Disease Division
Research focus includes the analysis of humoral immune response to HSV-2 and its vaccine candidates and understanding the role of tissue B cells in HSV-2 infection
Phone: (206) 667-5503
Fax: (206) 667-4411
Affiliate Professor, Department of Global Health, University of Washington
Research is focused on the development of a safe and effective vaccine to combat the spread of HIV and to investigate how HIV infection leads to AIDS. Two major areas of research is to better understand how neutralizing antibodies against HIV are developed during natural HIV-infection,and engineer immunogens that will elicit broadly neutralizing antibody responses against HIV.
Phone: (206) 667-2995
Fax: (206) 667-7767
Structural molecular immunology and vaccinology: using biophysical approaches to study proteins and interactions mediating or modulating adaptive and innate immune responses
Phone: (206) 667-5587
Fax: (206) 667-5939
Epidemiologic studies of infectious disease transmission, vaccine studies and the development of novel statistical methods and designs for studies of infectious disease transmission. Efficacy and effectiveness assessments of control and prevention strategies for infectious diseases of import to global health, including influenza, cholera, dengue, and tuberculosis
Assistant Member, Immunology and Vaccine Development, Vaccine and Infectious Disease Division
Affiliate Assistant Professor, Department of Global Health, University of Washington
Affiliate Assistant Professor, Department of Immunology, University of Washington
Faculty Member, Molecular & Cellular Biology Program, University of Washington
Research interests involve mechanisms driving the differentiation of B cells following vaccination and infection, understanding how differences in the pre-immune repertoire influences immunity and vaccine Development
Professor, Medicine, Laboratory Medicine, and Epidemiology, University of Washington
Graduate Faculty, Medicine, Laboratory Medicine, and Epidemiology, University of Washington
Head, Division of Allergy & Infectious Diseases, University of Washington
Attending Physician, SCCA Infectious Disease Consulting Service, Seattle Cancer Care Alliance
Epidemiology, natural history, therapy, and prevention of HSV and other herpesvirus infections; interactions between HSV and HIV Vaccines and clinical trials
Phone: (206) 520-4340