Microbiome of Humans

Vaccine and Infectious Disease Division

Human Microbiome

On a cellular basis, microorganisms outnumber human cells ten to one, and many scientists emphasize the importance of including these microbial cells and their genes when considering the genetic machinery available in our bodies. Indeed, the human body can be considered a “super-organism” or composite of human and microbial cells. The microbial communities that populate human tissue surfaces can vary greatly between individuals. Even different regions of the same organ (such as skin) can have very different microbial profiles. These microbes and their genes (the microbiome) can be seen as a modifiable environmental or genetic factor that influences human health. Recent advances in biomedical technologies, such as high throughput sequencing, have opened the door to truly characterizing these previously unseen effects on human health.

Faculty

Alphabetical Listing:

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Clinical trial data management, Logistics, operations and study facilitation, Scientific communications, Host-pathogen interactions High-dimensional data analysis
Director for Scientific Affairs, HIV Vaccine Trials Network
Affiliate Professor, Epidemiology and Global Health, University of Washington
The conduct of HIV vaccine trials, novel vaccine strategies, the conduct of clinical trials in resource-poor settings, and factors that help prevent sexual transmission of HIV.
Phone: (206) 667-7938
Fax: (206) 667-7711
Current studies include development of methods for T-cell based sieve analysis, quantification of vaccine induced T cell responses, systems biology of influenza and time-dependent correlates analysis of HIV efficacy trial.
Immune monitoring and correlative science analyses for early clinical trials in the area of cancer immunotherapy.
Affiliate Associate Professor, Biostatistics, University of Washington
Principal Investigator, Fong Group
Statistical problems in biological assays, Biological sequence analysis, Stochastic optimization
Phone: (206) 667-1093
Fax: (206) 667-4378
Professor, Medicine, University of Washington
Adjunct Associate Professor, Microbiology, University of Washington
Director, Infectious Diseases Fellowship Training Program, University of Washington
Determining how changes in microbial communities impact human health; identifying, characterizing, and culturing microbes found in the human genital tract; and associating the reproductive tract microbiome with human disease. Developing molecular diagnostic tests to detect and identify pathogens in immunocompromised hosts such as cancer patients.
Phone: (206) 667-1935
Fax: (206) 667-4411
Principal Staff Scientist, Vaccine and Infectious Disease Division
Clinical Associate Professor, Global Health, University of Washington
HIV and tuberculosis (Tb) vaccine research and development, human challenge experiments, microbiome modulation of immunity, immune activation—polymicrobial infections, combination HIV prevention, malaria clinical trials/vaccines and molecular epidemiology
Research interests include analysis of immune response to vaccine candidates, study design for pilot studies, statistical methods for biological assays, and infectious disease models.
Phone: (206) 667-2310
Staff Scientist, Fredricks Lab, Vaccine and Infectious Disease Division
Research focus includes the role of the microbiome in human health and disease.
Phone: (206) 667-2884
Medical Director of Infection Prevention, Seattle Cancer Care Alliance
Associate Professor, Department of Medicine, University of Washington
Adjunct Associate Professor, Epidemiology, University of Washington
Attending Physician, SCCA Infectious Disease Consulting Service, Seattle Cancer Care Alliance
Natural Killer Cell Receptor Diversity and CMV in Hematopoietic Cell Transplantation; Viral infections after Hematopoietic Stem Cell Transplantation; Epidemiology of invasive Fungal infections in Cord Blood Transplant Recipients and Clinical trials of the prevention of post-transplant infection
Phone: (206) 667-7538
Fax: (206) 667-4411
Research Professor, Biostatistics, University of Washington
Adjunct Research Professor, Global Health, University of Washington
Graduate Faculty, Biostatistics and Global Health, University of Washington
Statistical methods for analyzing infectious disease data; developing methods to analyze infectious disease data and developing methods to analyze data with missing values
Phone: (206) 667-7788
Fax: (206) 667-4378
Associate Member, Clinical Research Division
Associate Professor, Department of Medicine, University of Washington
Attending Physician, SCCA Infectious Consulting Service, Seattle Cancer Care Alliance
Interest in describing the quantitative and dynamical features of human pathogens and immune responses. Most of work to-date is on the pathogenesis of HSV-2 infection but also interested in applying models to optimize viral eradication startegies, and to use models to capture kinetic features of the human microbiome.
Senior Staff Scientist, Fredricks Lab, Vaccine and Infectious Disease Division
Research focus includes ecology of human microbial communities, impact of bacterial interactions on health and disease, molecular diagnosis of bacterial pathogens and bacterial adaptive responses
Professor, Medicine, Laboratory Medicine, and Epidemiology, University of Washington
Graduate Faculty, Medicine, Laboratory Medicine, and Epidemiology, University of Washington
Head, Division of Allergy & Infectious Diseases, University of Washington
Attending Physician, SCCA Infectious Disease Consulting Service, Seattle Cancer Care Alliance
Epidemiology, natural history, therapy, and prevention of HSV and other herpesvirus infections; interactions between HSV and HIV Vaccines and clinical trials
Phone: (206) 520-4340
Managing Director, China
Primary responsibility is to facilitate and provide a platform for Hutch faculty to conduct their research, expand their research interests and translate their knowledge globally, particular in China
Phone: (206) 667-1937