VIDD faculty interests focus on elucidating the immunobiology of infectious and malignant diseases and developing cellular and molecular strategies to manipulate innate and adaptive immunity for the treatment of human diseases. This includes research on infectious diseases that cause or are associated with developing cancer as well as infectious diseases prevalent in immunocompromised individuals, such as transplant patients. Our research expertise spans from bench to bedside and includes basic research studies as well as clinical trials. The knowledge gained in basic research studies is the key to developing new therapeutic approaches and vaccines. Investigating ways to eliminate or control infectious diseases via vaccination is a major goal.
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Co-infections impact clinical, virological, and immunologic outcomes in HIV. I work on understanding how we can better treat patients to prevent HIV and HIV-associated complications, including focus on HIV persistence and HIV-associated malignancies.
Characterizing T cells induced by candidate vaccines using flow cytometry. Developing new assays to evaluate vaccine efficacy with HIV Vaccine Trials Network. Studies include examining T cell function at the single-cell level using advanced flow cytometric techniques; examples include T cell responses to vaccination and to viral infections such as CMV, EBV, HIV, and hepatitis B.
Computational and statistical methods development for high-throughput, high-content biological data.
Modeling and integration of data from high throughput assays for biomarker discovery, clinical outcome prediction and disease classification.
Current studies include development of methods for T-cell based sieve analysis, quantification of vaccine induced T cell responses, systems biology of influenza and time-dependent correlates analysis of HIV efficacy trial.
Elucidating cellular mechanisms for control of HIV replication, Assessing cellular immune responses in HIV vaccine recipients, Teaching and Mentoring Interests, HIV immunology for experts and the public
Research focus includes vaccine clinical trials, the design and analysis of Phase I/II trials, for evaluating vaccine effects on immune responses; the design and analysis of Phase 2b/III trials, for evaluating vaccine efficacy, immune correlates, sieve analysis, and post-infection vaccine effects; general biostatistical methods research, such as survival analysis, causal inference, and evaluation of surrogate endpoints
Developing methods and tools for high throughput, high dimensional experiments with applications in vaccine research and immunology; flow cytometry, peptide microarrays, next generation sequencing; Bayesian inference and computation and statistical computing
Research focus included the design and evaluation of vaccine field trials; modeling infectious disease dynamics and strategies for mitigation and control; causal inference in infectious diseases; and evaluating surrogates of protection.
Immunologic endpoint determination for experimental vaccines (HIV, pneumococcus, malaria, TB, flu) and
Logistics, operations, quality assurance, and assay validation for immunologic evaluation of vaccines in the clinical trial setting
Research focus includes statistical methods for bioassays (e.g., flow cytometry, sequencing); dynamic modeling of biological systems (e.g., multi-type cell populations, B-cell repertoire); nonparametric methods for supervised and unsupervised learning; stochastic processes (e.g., branching processes); algorithms for scalable data analysis.
HIV and tuberculosis (Tb) vaccine research and development, human challenge experiments, microbiome modulation of immunity, immune activation—polymicrobial infections, combination HIV prevention, malaria clinical trials/vaccines and molecular epidemiology
Interest in describing the quantitative and dynamical features of human pathogens and immune responses. Most of work to-date is on the pathogenesis of HSV-2 infection but also interested in applying models to optimize viral eradication startegies, and to use models to capture kinetic features of the human microbiome.
Research is focused on the development of a safe and effective vaccine to combat the spread of HIV and to investigate how HIV infection leads to AIDS. Two major areas of research is to better understand how neutralizing antibodies against HIV are developed during natural HIV-infection,and engineer immunogens that will elicit broadly neutralizing antibody responses against HIV.
Research interests involve mechanisms driving the differentiation of B cells following vaccination and infection, understanding how differences in the pre-immune repertoire influences immunity and vaccine Development
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