Vaccine and Infectious Disease Division
While vaccine and drug development have largely dominated the HIV field since the epidemic emerged, the past several years have brought about the burgeoning field of HIV cure. VIDD faculty are developing innovative approaches such as genome editing and genetically modified T cells to eradicate the latent viral reservoir in HIV+ individuals. Preclinical models of HIV infection are central to performing these immunotherapy experiments and have already begun to show great success.
Select a letter to display a list of Faculty members
Clinical trial data management, Logistics, operations and study facilitation, Scientific communications, Host-pathogen interactions
High-dimensional data analysis
Research focus is HIV and herpesvirus vaccine development, herpes simplex virus type 2 (HSV-2) pathogenesis and the host immune response. Immunotherapeutic approaches to viral infections and cancer
Phone: (206) 667-6770
Fax: (206) 667-7711
Characterizing T cells induced by candidate vaccines using flow cytometry. Developing new assays to evaluate vaccine efficacy with HIV Vaccine Trials Network. Studies include examining T cell function at the single-cell level using advanced flow cytometric techniques; examples include T cell responses to vaccination and to viral infections such as CMV, EBV, HIV, and hepatitis B.
The conduct of HIV vaccine trials, novel vaccine strategies, the conduct of clinical trials in resource-poor settings, and factors that help prevent sexual transmission of HIV.
Phone: (206) 667-7938
Fax: (206) 667-7711
Elucidating cellular mechanisms for control of HIV replication, Assessing cellular immune responses in HIV vaccine recipients, Teaching and Mentoring Interests, HIV immunology for experts and the public
Developing methods and tools for high throughput, high dimensional experiments with applications in vaccine research and immunology; flow cytometry, peptide microarrays, next generation sequencing; Bayesian inference and computation and statistical computing
Phone: (206) 667-4076
Fax: (206) 667-4378
Combines laboratory studies and systems biology tools to understand the interplay between pathogens, the mucosa, and medical interventions
Phone: (206) 667-6848
Fax: (206) 667-7767
Clinically important persistent and latent viral infections; curative therapies for latent viral infections ;diagnosis of disease caused by herpesviruses, enterovirus, JC and BK viruses, parvovirus B19, and hepatitis viruses
Phone: (206) 667-6793
Fax: (206) 667-6179
The Kiem Lab is focused on research and clinical trials using stem cell biology and stem cell gene transfer with the goal of developing stem cell-based treatment strategies for patients with genetic or infectious stem cells. We are conducting studies using embryonic stem cells and induced pluripotent stem cells.
Phone: (206) 667-4409
Fax: (206) 667-6124
Regulatory T cells in modulation of anti-viral immunity; HIV immunology; and immunogenetics and virus infection
Research centers on developing an HIV vaccine and investigating the complex relationship between HIV and the immune system and the influence of antiretroviral therapy.
Interest in describing the quantitative and dynamical features of human pathogens and immune responses. Most of work to-date is on the pathogenesis of HSV-2 infection but also interested in applying models to optimize viral eradication startegies, and to use models to capture kinetic features of the human microbiome.
Research focus includes the analysis of humoral immune response to HSV-2 and its vaccine candidates and understanding the role of tissue B cells in HSV-2 infection
Phone: (206) 667-5503
Fax: (206) 667-4411