Vaccine and Infectious Disease Division
Photo by Robert Hood / Fred Hutch News Service
VIDD’s research aims at preventing, diagnosing, treating and understanding infectious diseases. There is a wide range of research topics under investigation across the fields of biology, medicine and public health. VIDD is organized into four research programs that integrate multiple research interests.
Using mathematical modeling, computational biology, epidemiology and statistics, scientists determine how infectious diseases are spread and contained. Our researchers are creating a platform for integrated research that allows biostatistics, bioinformatics and population modeling to be engaged throughout vaccine design, development, evaluation and implementation.
Our researchers are working to reduce the burden of cancers around the world through improved diagnosis, better prevention strategies and optimized treatment plans. We have a particular emphasis on the 20 percent of cancers worldwide that are caused by infectious diseases. To address these cancers we are focusing on the support of research, clinical care and training of cancer specialists, scientists and support staff in Uganda and other countries. The cornerstone of our research and clinical work in global oncology is our decade-long collaboration with the Uganda Cancer Institute (UCI) in Kampala, Uganda.
Scientists here focus on immunopathogenesis and host genetics, vaccine immune monitoring and HIV vaccine and adjuvant design. Research in this discipline is focused on translating fundamental knowledge about the immune system and its regulation to the design of vaccine reagents and regimens that induce broader and more effective responses and to the development of novel therapies for cancer, HIV, tuberculosis, malaria and other related infectious diseases.
Our scientists apply laboratory, clinical and computational approaches to advance our knowledge and understanding of infectious diseases. The program concentrates on ways to detect, prevent and treat infectious diseases as well as mitigate serious complications in immunocompromised individuals that are at high risk for disease transmission and acquisition.
Biostatistics — conduct research in statistical methodology for the design and analysis of clinical, epidemiological and basic science studies, and conduct research into biologically based mathematical models for pathogenesis.
Computational Biology — develop novel computational methods and tools that are used to analyze and integrate high throughput biological assays for a better understanding of infectious disease processes and host immune responses.
Epidemiology — study disease distribution in human populations and examination of disease origin and prevention.
HIV Cure — use innovative approaches such as genome editing and genetically modified T cells to eradicate the latent viral reservoir in HIV+ individuals.
Human Microbiome — investigate how microbial communities affect human health and develop innovative technologies for microbiota detection.
Immunology — elucidate the immunobiology of infectious and malignant diseases and develop cellular and molecular strategies to manipulate innate and adaptive immunity for the treatment of human diseases.
Infection-Related Malignancies — investigate how cancer-causing infections are transmitted and acquired, and determine factors that govern the progression from chronic infection to cancer.
Infections in the Immunocompromised Host — study opportunistic infections in cancer patients undergoing immunosuppressive therapy and post transplant recipients.
Mathematical Modeling — use mathematical and statistical modeling to study the dynamics and mechanisms of complex biological systems such as human disease processes.
Vaccine Development — reduce disease prevalence from vaccination from idea conception to clinical trial design, vaccine production and data analysis.
Viral Infections — develop prevention strategies and therapeutic options for many viruses of global health significance.