Vaccine and Infectious Disease Division

Vaccine Development

Chronic infections present a large global health threat and therefore prevention is currently a major focus for reducing disease prevalence. The prevention strategies of vaccination have shown some highly promising results on diseases such as HIV and HSV-1, and the advancement and evolution of vaccine development in VIDD involves an ambitious team of scientists. Basic scientists, computer and animal modelers, statisticians, epidemiologists and clinicians work together throughout this rigorous process, from idea conception to clinical trial design and finally to vaccine production.

Faculty

Staff Scientist, McElrath Lab, Vaccine and Infectious Disease Division
Research interests include early innate immune responses to HIV vaccines on subsequent adaptive immune responses and systems biology analyses of how immune responses are shaped
Clinical Assistant Professor, Global Health, University of Washington
Research interests include sexual risk taking, victimization and alcohol/drug abuse among African-American women, HIV prevention for African American and African-born populations and health disparities.
Phone: (206) 667-2074
Fax: (206) 667-6366
Characterizing the humoral immune response and mechanisms of antibody-mediated protection to candidate HSV-2 vaccines using antibody binding, neutralization and antibody-dependent cell-mediated cytotoxicity assays.
Research Associate Professor, Laboratory Medicine, University of Washington
Graduate Faculty, Laboratory Medicine, University of Washington
Director, Center for AIDS Research Immunology Core, University of Washington
Characterizing T cells induced by candidate vaccines using flow cytometry. Developing new assays to evaluate vaccine efficacy with HIV Vaccine Trials Network. Studies include examining T cell function at the single-cell level using advanced flow cytometric techniques; examples include T cell responses to vaccination and to viral infections such as CMV, EBV, HIV, and hepatitis B.
Director for Scientific Affairs, HIV Vaccine Trials Network
Affiliate Professor, Epidemiology and Global Health, University of Washington
The conduct of HIV vaccine trials, novel vaccine strategies, the conduct of clinical trials in resource-poor settings, and factors that help prevent sexual transmission of HIV.
Phone: (206) 667-7938
Fax: (206) 667-7711
Affiliate Assistant Professor, Biostatistics, University of Washington
Statistical and computational methods for bioinformatics applications, statistical modeling for genome sequence analysis and statistical modeling frameworks. The interface between computer science, statistics, and molecular biologyand such as development of new informatics methods in genomics and post-genomics
Phone: (206) 667-4086
Fax: (206) 667-4378
Affiliate Assistant Professor, Biostatistics, University of Washington
Statistical problems in biological assays, Biological sequence analysis, Stochastic optimization
Phone: (206) 667-1093
Fax: (206) 667-4378
Associate Director for Laboratory Science, HIV Vaccine Trials Network
Associate Professor, Department of Global Health, University of Washington
Graduate Faculty, Global Health, University of Washington
Elucidating cellular mechanisms for control of HIV replication, Assessing cellular immune responses in HIV vaccine recipients, Teaching and Mentoring Interests, HIV immunology for experts and the public
Principal Investigator, Statistical Data Management Center, HIV Vaccine Trials Network
Research Professor, Biostatistics, University of Washington
Graduate Faculty, Biostatistics, University of Washington
Research focus includes vaccine clinical trials, the design and analysis of Phase I/II trials, for evaluating vaccine effects on immune responses; the design and analysis of Phase 2b/III trials, for evaluating vaccine efficacy, immune correlates, sieve analysis, and post-infection vaccine effects; general biostatistical methods research, such as survival analysis, causal inference, and evaluation of surrogate endpoints
Phone: (206) 667-7299
Fax: (206) 667-4812
Affiliate Associate Professor, Statistics, University of Washington
Developing methods and tools for high throughput, high dimensional experiments with applications in vaccine research and immunology; flow cytometry, peptide microarrays, next generation sequencing; Bayesian inference and computation and statistical computing
Phone: (206) 667-4076
Fax: (206) 667-4378
Clinical Trials Physician /Protocol Team Leader, HIV Vaccine Trials Network (HVTN)
Immunology and vaccine design for development of vaccines, especially HIV-1 vaccine
Host-pathogen co-evolution, T-cell and B-cell immunodominance and the effects of immunological history.
Affiliate Associate Professor, Biostatistics, University of Washington
Statistical methods in biomarker evaluation for disease screening, surrogate endpoint identification, and treatment selection; genome-wide association studies and causal inference
Phone: (206) 667-4198
Fax: (206) 667-4378
Principal Staff Scientist, Vaccine and Infectious Disease Division
Principal Staff Scientist, Public Health Sciences Division
Unit Head, Biostatistical Collaborative Unit for Study Design and Data Analysis, Vaccine Immunology Statistical Center
Research focus include the design and analysis of clinical trials
Phone: (206) 667-5780
Fax: (206) 667-4378
Associate Director for Laboratory Operations, HIV Vaccine Trials Network (HVTN)
Immunologic endpoint determination for experimental vaccines (HIV, pneumococcus, malaria, TB, flu) and Logistics, operations, quality assurance, and assay validation for immunologic evaluation of vaccines in the clinical trial setting
Director of Clinical Development, HIV Vaccine Trials Network (HVTN)
Clinical Trials Physician/Protocol Team Leader, HIV Vaccine Trials Network (HVTN)
HIV vaccine development and trial design, combination HIV prevention, mucosal immunology and mucosal sampling design in HIV prevention trials, the intersection of oncology and infectious disease, comparative effectiveness, decision analysis and health-related quality of life
Principal Staff Scientist, Vaccine and Infectious Disease Division
Clinical Associate Professor, Global Health, University of Washington
HIV and tuberculosis (Tb) vaccine research and development, human challenge experiments, microbiome modulation of immunity, immune activation—polymicrobial infections, combination HIV prevention, malaria clinical trials/vaccines and molecular epidemiology
Senior Staff Scientist, Public Health Sciences Division
Development of genetic statistical methodologies, including phylogenetic tree reconstruction from genetic sequences
Research Assistant Professor, Global Health, University of Washington
Graduate Faculty, Global Health, University of Washington
Roles of regulatory T cells in modulating anti-viral immunity; anti-viral immunity; vaccine development
Senior Vice President and Director, Vaccine and Infectious Disease Division
Professor of Medicine, University of Washington
Adjunct Professor, Pathobiology, Global Health, and Laboratory Medicine, University of Washington
Research centers on developing an HIV vaccine and investigating the complex relationship between HIV and the immune system and the influence of antiretroviral therapy.
Senior Staff Scientist, Public Health Sciences Division
Research focus includes vaccine clinical trials, SNP analysis, novel statistical methodology, nonparametric methods
Phone: (206) 667-7077
Fax: (206) 667-4378
Affiliate Assistant Professor, Department of Global Health, University of Washington
Faculty Member, Interdisciplinary Program in Pathobiology, University of Washington
Faculty Member, Molecular & Cellular Biology Program, Fred Hutch & University of Washington
Study T cell fate and function in healthy and inflamed tissues and following infection with HIV and manipulate these responses for therapeutic purposes
Phone: (206) 667-2216
Fax: (206) 667-2209
Structural molecular immunology and vaccinology: using biophysical approaches to study proteins and interactions mediating or modulating adaptive and innate immune responses
Phone: (206) 667-5587
Professor, Medicine, Laboratory Medicine, and Epidemiology, University of Washington
Graduate Faculty, Medicine, Laboratory Medicine, and Epidemiology, University of Washington
Attending Physician, SCCA Infectious Disease Consulting Service, Seattle Cancer Care Alliance
Epidemiology, natural history, therapy, and prevention of HSV and other herpesvirus infections; interactions between HSV and HIV Vaccines and clinical trials
Phone: (206) 520-4340
Senior Staff Scientist, Public Health Sciences Division
Research focus includes analysis of HIV-1 CFSE assay data, cross-protocol analysis of DNA and Pox exploratory analysis and statistical methods for viral load set points
Phone: (206) 667-7008
Fax: (206) 667-4378