Vaccine and Infectious Disease Division

Tuberculosis

Tuberculosis, caused by the bacterium Mycobacterium tuberculosis, remains one of the 3 most deadly infections globally. Current preventive (vaccine) and therapeutic (antibiotic) resources for tuberculosis exist, but have been inadequate to significantly reduce disease burden. Co-infection with HIV has increased the incidence of and mortality from both diseases and this interaction has spurred interest in implementation of integrated health care services. VIDD scientists are developing mathematical modeling tools in combination with clinical trial design for studying the effects of potential prevention and therapeutics on morbidity and mortality from tuberculosis.

Faculty

Research Professor, Biostatistics, University of Washington
Graduate Faculty, Biostatistics, University of Washington
PI, Statistical and Data Management Center, Microbicide Trials Network
Design and analysis of trials for HIV prevention, joint models for longitudinal and survival data and statistical methods in HIV/AIDS and cardiovascular research.
Phone: (206) 667-1731
Fax: (206) 667-4812
Research Associate Professor, Laboratory Medicine, University of Washington
Graduate Faculty, Laboratory Medicine, University of Washington
Director, Center for AIDS Research Immunology Core, University of Washington
Characterizing T cells induced by candidate vaccines using flow cytometry. Developing new assays to evaluate vaccine efficacy with HIV Vaccine Trials Network. Studies include examining T cell function at the single-cell level using advanced flow cytometric techniques; examples include T cell responses to vaccination and to viral infections such as CMV, EBV, HIV, and hepatitis B.
Associate Director for Laboratory Science, HIV Vaccine Trials Network
Associate Professor, Department of Global Health, University of Washington
Graduate Faculty, Global Health, University of Washington
Elucidating cellular mechanisms for control of HIV replication, Assessing cellular immune responses in HIV vaccine recipients, Teaching and Mentoring Interests, HIV immunology for experts and the public
Principal Staff Scientist, Vaccine and Infectious Disease Division
Principal Staff Scientist, Public Health Sciences Division
Unit Head, Biostatistical Collaborative Unit for Study Design and Data Analysis, Vaccine Immunology Statistical Center
Research focus include the design and analysis of clinical trials
Phone: (206) 667-5780
Fax: (206) 667-4378
Associate Director for Laboratory Operations, HIV Vaccine Trials Network (HVTN)
Immunologic endpoint determination for experimental vaccines (HIV, pneumococcus, malaria, TB, flu) and Logistics, operations, quality assurance, and assay validation for immunologic evaluation of vaccines in the clinical trial setting
Principal Staff Scientist, Vaccine and Infectious Disease Division
Clinical Associate Professor, Global Health, University of Washington
HIV and tuberculosis (Tb) vaccine research and development, human challenge experiments, microbiome modulation of immunity, immune activation—polymicrobial infections, combination HIV prevention, malaria clinical trials/vaccines and molecular epidemiology
Senior Staff Scientist, Public Health Sciences Division
Development of genetic statistical methodologies, including phylogenetic tree reconstruction from genetic sequences
Senior Vice President and Director, Vaccine and Infectious Disease Division
Professor of Medicine, University of Washington
Adjunct Professor, Pathobiology, Global Health, and Laboratory Medicine, University of Washington
Research centers on developing an HIV vaccine and investigating the complex relationship between HIV and the immune system and the influence of antiretroviral therapy.
Affiliate Assistant Professor, Department of Global Health, University of Washington
Faculty Member, Interdisciplinary Program in Pathobiology, University of Washington
Faculty Member, Molecular & Cellular Biology Program, Fred Hutch & University of Washington
Study T cell fate and function in healthy and inflamed tissues and following infection with HIV and manipulate these responses for therapeutic purposes
Phone: (206) 667-2216
Fax: (206) 667-2209